Listar por autor "Labella Vera, Alejandro Manuel"
Mostrando ítems 1-20 de 60
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An Efficient Machine Learning Method to Identify Genetic Drivers of Avian Influenza Virus Adaptation to Humans
Leiva Rebollo, Rocío; Patiño Galindo, Juan; Villalon Letelier, Fernando; Mena, Nacho; Tansey, W; Park, K; Labella Vera, Alejandro Manuel; Castro-López, María Dolores
; Borrego-García, Juan José; Rabadán, Raúl; García Sastre, Adolfo[et al.] (2024-09-02)
In this work we developed a method, based on a logistic regression model, to identify mutations subject to directional selection. We tested the model analyzing thousands of AIV (H5N1, H7N9) sequences from public datasets, ... -
Análisis de la expresión de inmunogenes en doradas vacunadas en respuesta a la infección por LCDV-Sa
Leiva-Rebollo, Rocío; Gémez-Mata, Juan; Labella Vera, Alejandro Manuel; Castro-López, María Dolores; Borrego-García, Juan José (2021)
El objetivo del presente estudio ha sido evaluar la respuesta inmune frente a la infección por Lymphocystis Disease Virus 3 (LCDV-Sa) en ejemplares de dorada (Sparus aurata) vacunados con un plásmido que codifica la proteína ... -
Analysis of gene expression in nodavirus-inoculated Senegalese sole using a new Openarray® platform.
Labella Vera, Alejandro Manuel; Gémez Mata, Juan; Vera, Isabel; Bandin, Isabel; Leiva Rebollo, Rocío; Borrego-García, Juan José; García-Rosado, Esther[et al.] (Elsevier, 2019)
Nervous necrosis virus (NNV) is the causative agent of the viral encephalopathy and retinopathy, a disease that affects cultured Senegalese sole (Solea senegalensis). A NNV reassortant (Ss160.03), combining genomic segments ... -
Application of a new real-time polymerase chain reaction assay for surveillance studies of lymphocystis disease virus in farmed gilthead seabream
Valverde, Estefanía J.; Cano, Irene; Labella Vera, Alejandro Manuel; Borrego-García, Juan José; Castro-López, María Dolores (BMC, 2016-04-06)
Background: Lymphocystis disease (LCD) is the main viral infection reported to affect cultured gilthead seabream (Sparus aurata) in Europe. The existence of subclinical Lymphocystis disease virus (LCDV) infection in this ... -
Artemia spp., a Susceptible Host and Vector for Lymphocystis Disease Virus.
Jiménez Valverde, Estefanía; Labella Vera, Alejandro Manuel; Borrego-García, Juan José; Castro-López, María Dolores (MDPI, 2019-06-01)
Di erent developmental stages of Artemia spp. (metanauplii, juveniles and adults) were bath-challenged with two isolates of the Lymphocystis disease virus (LCDV), namely, LCDV SA25 (belonging to the species Lymphocystis ... -
Co-occurrence of viral and bacterial pathogens in disease outbreaks affecting newly cultured sparid fish
García-Rosado, Esther; Cano, Irene; Martín-Antonio, Beatriz; Labella Vera, Alejandro Manuel; Manchado, Manuel; Alonso, María del Carmen; Castro, Dolores; Borrego, Juan José[et al.] (Springer, 2007-09-01)
Several microbial disease outbreaks in farm stocks of newly cultured sparid fish species, such as common seabream, redbanded seabream, and white seabream, were recorded from 2004 to 2006. This study describes the isolation ... -
Concurrence of Iridovirus, Polyomavirus, and a Unique Member of a New Group of Fish Papillomaviruses in Lymphocystis Disease-Affected Gilthead Sea Bream
(ASM Journals, 2016-09-12)Lymphocystis disease is a geographically widespread disease affecting more than 150 different species of marine and freshwater fish. The disease, provoked by the iridovirus lymphocystis disease virus (LCDV), is characterized ... -
Desarrollo de un chip de DNA para la detección de dianas génicas bacterianas de interés en el campo de la acuicultura
Labella Vera, Alejandro Manuel; Trento, I.; Ghidini, V.; Gennari, M.; Castro-López, María Dolores; Borrego-García, Juan José; Lleò, M.M.[et al.] (2014-10-07)
La adquisición bacteriana de multiresistencias frente a antimicrobianos es un fenómeno cada vez más preocupante, con gran repercusión para la salud pública, pero también con impacto en sectores de la producción animal, ... -
Desarrollo de una vacuna DNA para el control de la enfermedad de linfocistis
Leiva, Rocío; Borrego-García, Juan José; Castro-López, María Dolores; Labella Vera, Alejandro Manuel (2018-06-20)
El virus de la enfermedad de linfocistis (LCDV) es el agente etiológico de la enfermedad de linfocistis, que afecta tanto a peces marinos como dulceacuícolas. Esta enfermedad supone un grave problema para el sector de la ... -
Desarrollo y evaluación de una vacuna DNA contra el virus de la enfermedad de linfocistis (LCDV)
Leiva, Rocío; Labella Vera, Alejandro Manuel; Castro-López, María Dolores; Borrego-García, Juan José (2018-10-23)
El virus de la enfermedad de linfocistis (LCDV) infecta tanto a peces marinos como dulceacuícolas, produciendo una patología que supone un grave problema para la acuicultura debido a las pérdidas económicas asociadas a su ... -
Description of New and Amended Clades of the Genus Photobacterium.
Labella Vera, Alejandro Manuel; Castro-López, María Dolores; Manchado, Manuel; Borrego-García, Juan José (MDPI, 2018-03-12)
Phylogenetic relationships between species in the genus Photobacterium have been poorly studied despite pathogenic and ecological relevance of some of its members. This is the first phylogenetic study that includes new ... -
Detección y cuantificación del virus de la enfermedad de linfocistis mediante ensayo ICC-RT-PCR (integrated cell culture-RT-PCR)
Jiménez Valverde, Estefanía; Leiva, Rocío; Labella Vera, Alejandro Manuel; Borrego-García, Juan José; Castro-López, María Dolores (2015-07-21)
La enfermedad de linfocistis es la enfermedad de etiología viral más frecuentemente detectada en la acuicultura marina europea, siendo la principal patología de origen vírico descrita en doradas cultivadas. El agente ... -
Differential immunogene expression profile of European sea bass (Dicentrarchus labrax, L.) in response to highly and low virulent NN
Moreno, Patricia; Gémez-Mata, Juan; García-Rosado, Esther; Béjar-Alvarado, Julia; Labella Vera, Alejandro Manuel; Souto, Sandra; Alonso-Sánchez, María del Carmen[et al.] (Elsevier, 2020)
European sea bass is highly susceptible to the nervous necrosis virus, RGNNV genotype, whereas natural outbreaks caused by the SJNNV genotype have not been recorded. The onset and severity of an infectious disease depend ... -
Evaluación de la respuesta inmune en doradas tras la administración de una vacuna inactivada frente a betanodavirus
Gémez-Mata, Juan; Leiva-Rebollo, Rocío; Moreno, Patricia; Borrego-García, Juan José; García-Rosado, Esther; Labella Vera, Alejandro Manuel; Castro-López, María Dolores[et al.] (2023)
El virus de la necrosis nerviosa (VNN), género Betanodavirus, familia Nodaviridae, es el agente etiológico de la necrosis nerviosa viral, enfermedad que afecta a peces cultivados en todo el mundo. Existen cuatro especies ... -
Evaluación de la respuesta inmune en lenguado senegalés conferida por una vacuna inactivada frente a Betanodavirus
Gémez-Mata, Juan; Leiva-Rebollo, Rocío; López-Vázquez, Carmen; Olveira, José G.; Bandín Matos, Isabel; Borrego-García, Juan José; Castro-López, María Dolores; Labella Vera, Alejandro Manuel[et al.] (2022)
La necrosis nerviosa viral es una enfermedad que afecta a peces cultivados en todo el mundo. Su agente etiológico es el virus de la necrosis nerviosa, género Betanodavirus, familia Nodaviridae, que presenta un genoma ... -
Evaluation of gilthead seabream (Sparus aurata) immune response after LCDV DNA vaccination
Leiva-Rebollo, Rocío; Castro-López, María Dolores; Borrego-García, Juan José; Labella Vera, Alejandro Manuel (2019-10-07)
A DNA vaccine against Lymphocystis Disease Virus (LCDV) was developed and its protective efficacy in gilthead seabream (Sparus aurata) has been established. The aim of the present study is the evaluation of immune-related ... -
Evaluation of Gilthead Seabream (Sparus aurata) Immune Response after LCDV-Sa DNA Vaccination
Leiva Rebollo, Rocío; Castro-López, María Dolores; Moreno García, Patricia; Borrego-García, Juan José; Labella Vera, Alejandro Manuel (MDPI, 2021-05-29)
Lymphocystis disease is the main viral pathology in gilthead seabream aquaculture. Currently, there are no treatments or vaccines to control this disease, thus our main goal was to construct a DNA vaccine that can be used ... -
Evaluation of immune response after LCDV-Sa infection in DNA-vaccinated gilthead seabream
Leiva-Rebollo, Rocío; Gémez-Mata, Juan; Castro-López, María Dolores; Borrego-García, Juan José; Labella Vera, Alejandro Manuel (2021)
The immune-related gene expression in vaccinated gilthead seabream after Lymphocystis Disease Virus 3 (LCDV-Sa) infection was analysed by using an OpenArray based on TaqMan qPCR. The DNA vaccine used in this study encodes ... -
Evaluation of the immune response in betanodavirus-vaccinated gilthead seabream.
Gémez-Mata, Juan; Leiva-Rebollo, Rocío; Moreno-García, Patricia; Bandín Matos, Isabel; Borrego-García, Juan José; Labella Vera, Alejandro Manuel; Castro-López, María Dolores[et al.] (2023)
An inactivated vaccine has been developed using a RGNNV/SJNNV reassortant strain isolated from Senegalese sole, which confers moderate protection against the homologous viral strain in sole juveniles. The aim of this study ... -
Evidence for horizontal gene transfer, gene duplication and genetic variation as driving forces of the diversity of haemolytic phenotypes in Photobacterium damselae subsp. damselae
(Oxford Academic, 2014-06-01)Photobacterium damselae subsp. damselae, a marine bacterium that causes infections in marine animals and in humans, produces up to three different haemolysins involved in virulence, which include the pPHDD1 plasmidenco ...