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Bone organoid generation based on double scaffolding.
Decellularized bone matrix ( is a classic approach in bone tissue engineering based on the removal of bone tissue cells and the calcified phase using chemical, physical o enzymatic agents The resulting matrix preserves ... -
DEPTOR promotes bone marrow adipose tissue expansion in calorie restricted mice.
Elevated levels of fat in bones is a characteristic feature of osteoporosis and other skeletal disorders. While the molecular mechanism behind this shift between bone and fat formation remains incompletely understood, it ... -
Generation and analysis of ESTs from strawberry (Fragaria xananassa) fruits and evaluation of their utility in genetic and molecular studies
Bombarely, Aureliano; Merchante-Berg, Catharina; Csukasi, Fabiana; Cruz-Rus, Eduardo; Caballero, José L.; Medina-Escobar, Nieves; Blanco-Portales, Rosario; Botella, Miguel A.; Muñoz-Blanco, Juan; Sánchez-Sevilla, José F; Valpuesta-Fernández, Victoriano[et al.] (BMC, 2010-09-17)Cultivated strawberry is a octoploid species whose fruit is highly appreciated due to its organoleptic properties and health benefits. However, information about the role played by different hormones on these processes ... -
Modification of plant hormone levels and signaling as a tool in plant biotechnology.
Csukasi, Fabiana; Merchante-Berg, Catharina; Valpuesta-Fernández, Victoriano (Wiley, 2009-09-23)Plant hormones are signal molecules, present in trace quantities, that act as major regulators of plant growth and development. They are involved in a wide range of processes such as elongation, flowering, root formation ... -
Mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia
Barad, M.; Csukasi, Fabiana; Krakow, D.; Durán-Jimenez, Iván Jesús (2020-09-24)In addition to its structural role in skeletogenesis, the extracellular matrix (ECM), particularly basement membrane proteins, facilitates communication with intracellular signaling pathways and cell to cell interactions ... -
Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR
Csukasi, Fabiana (2022)Alterations in the balance between skeletogenesis and adipogenesis is a pathogenic feature in multiple skeletal disorders. Clinically, enhanced bone marrow adiposity in bones impairs mobility and increases fracture risk, ... -
The Skeletal Atlas: A holistic approach to transcriptomics in the skeleton.
Pérez-Tejeiro, José Miguel; Csukasi, Fabiana; Becerra-Ratia, José; Durán-Jimenez, Iván Jesús; Fernández-Pozo, Noé (2023)Gene expression atlases are powerful bioinformatics tools that allow access to the scientific community to explore omics data. In biomedicine, numerous gene expression databases are available, yet none provide enough ...