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Listar por autor "Dorner, M"
Mostrando ítems 1-4 de 4
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3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection.
Ortega-Prieto, Ana Maria; Skelton, J.K.; Wai, S.N.; Large, E.; Lussignol, M.; Vizcay-Barrena, G.; Hughes, D.; Fleck, R.A.; Thursz, M.; Catanese, M.T.; Dorner, M.[et al.] (Springer-Nature, 2018-02-14)With more than 240 million people infected, hepatitis B virus (HBV) is a major health concern. The inability to mimic the complexity of the liver using cell lines and regular primary human hepatocyte (PHH) cultures pose ... -
Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models
Liu, PJ; Harris, JM; Marchi, E; D'Arienzo, V; Michler, T; Wing, PAC; Magri, A; Ortega-Prieto, Ana Maria; van de Klundert, M; Wettengel, J; Durantel, D; Dorner, M; Klenerman, P; Protzer, U; Giotis, ES; McKeating, JA[et al.] (2020)Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC) worldwide. The prolyl hydroxylase domain (PHD)-hypoxia inducible factor (HIF) pathway is a key mammalian oxygen sensing pathway and is frequently ... -
"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection.
Ortega-Prieto, Ana Maria; Skelton, J.K.; Cherry, Catherine; Briones-Orta, Marco Antonio; Hateley, Charlotte Alexandra; Dorner, M[et al.] (JoVE, 2019)Despite the exceptional infectivity of the hepatitis B virus (HBV) in vivo, where only three viral genomes can result in a chronicity of experimentally infected chimpanzees, most in vitro models require several hundreds ... -
T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses.
Reynolds, CJ; Suleyman, OM; Ortega-Prieto, Ana Maria; Skelton, J.K.; Bonnesoeur, P; Blohm, A; Carregaro, V; Silva, J.S.; James, E.A.; Maillère, B; Dorner, M; Boyton, R.J.; Altmann, D.M.[et al.] (Springer Nature, 2018)Zika virus (ZIKV) Infection has several outcomes from asymptomatic exposure to rash, conjunctivitis, Guillain-Barré syndrome or congenital Zika syndrome. Analysis of ZIKV immunity is confounded by the fact that several ...