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Immunoproteasome activation enables human TRIM5α restriction of HIV-1
Jiménez-Guardeño, José Manuel; Apolonia, Luis; Betancor, Gilberto; Malim, Michael H. (Springer Nature, 2019)Type 1 interferon suppresses viral replication by upregulating the expression of interferon-stimulated genes with diverse antiviral properties1. The replication of human immunodeficiency virus type 1 (HIV-1) is naturally ... -
Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans
Seow, Jeffrey; Graham, Carl; Merrick, Blair; Acors, Sam; Pickering, Suzanne; Steel, Kathryn JA; Hemmings, Oliver; O'Byrne, Aoife; Kouphou, Neophytos; Galao, Rui Pedro; Betancor, Gilberto; Wilson, Harry D; Signell, Adrian W; Winstone, Helena; Kerridge, Claire; Huettner, Isabella; Jimenez-Guardeño, Jose Manuel; Lista, Maria Jose; Temperton, Nigel; Snell, Luke B; Bisnauthsing, Karen; Moore, Amelia; Green, Adrian; Martinez, Lauren; Stokes, Brielle; Honey, Johanna; Izquierdo-Barras, Alba; Arbane, Gill; Patel, Amita; Ik Tan, Mark Kia; O'Connell, Lorcan; O'Hara, Geraldine; MacMahon, Eithne; Douthwaite, Sam; Nebbia, Gaia; Batra, Rahul; Martinez-Nunez, Rocio; Shankar-Hari, Manu; Edgeworth, Jonathan D; Neil, Stuart JD; Malim, Michael H.; Doores, Katie J[et al.] (2020)Antibody responses to SARS-CoV-2 can be detected in most infected individuals 10-15 d after the onset of COVID-19 symptoms. However, due to the recent emergence of SARS-CoV-2 in the human population, it is not known how ... -
Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction
Dicks, Matthew DJ; Betancor, Gilberto; Jimenez-Guardeño, Jose Manuel; Pessel-Vivares, Lucie; Apolonia, Luis; Goujon, Caroline; Malim, Michael H.[et al.] (Public Library of Science, 2018)Human myxovirus resistance 2 (MX2/MXB) is an interferon-induced post-entry inhibitor of human immunodeficiency virus type-1 (HIV-1) infection. While the precise mechanism of viral inhibition remains unclear, MX2 is localized ... -
MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation
Betancor, Gilberto; Jimenez-Guardeño, Jose Manuel; Lynham, Steven; Antrobus, Robin; Khan, Hataf; Sobala, Andrew; Dicks, Matthew DJ; Malim, Michael H.[et al.] (Springer Nature, 2021)The antiviral cytokine interferon activates expression of interferon-stimulated genes to establish an antiviral state. Myxovirus resistance 2 (MX2, also known as MxB) is an interferon-stimulated gene that inhibits the ... -
TRIM5-mediated retrovirus restriction is modulated by type I interferon.
Ortega-Prieto, Ana María; Boehmer, Nina; Dinc, Hanife; Betancor, Gilberto; Petrosyan, Eduard; Malim, Michael H.; Jiménez-Guardeño, José Manuel[et al.] (2024)Since the identification in 2004 of the interferon-stimulated gene (ISG) tripartite motif-containing protein 5 α (TRIM5α) from rhesus macaques as a restriction factor preventing HIV-1 infection in these monkeys, the ...