Listar por autor "Segovia-Zafra, Antonio"
Mostrando ítems 1-6 de 6
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Control compounds for preclinical drug-induced liver injury assessment: Consensus-driven systematic review by the ProEuroDILI network
(Elsevier, 2024)Background & Aims Idiosyncratic drug-induced liver injury (DILI) is a complex and unpredictable event caused by drugs, and herbal or dietary supplements. Early identification of human hepatotoxicity at preclinical stages ... -
Critical Review of Gaps in the Diagnosis and Management of Drug-Induced Liver Injury Associated with Severe Cutaneous Adverse Reactions
Villanueva-Paz, Marina; Niu, Hao; Segovia-Zafra, Antonio; Medina-Cáliz, Inmaculada
; Sanabria-Cabrera, Judith Adriana; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Alvarez-Alvarez, Ismael; Sanabria-Cabrera, Judith Adriana[et al.] (MDPI, 2021-11-15)
Drug-induced liver injury (DILI) encompasses the unexpected damage that drugs can cause to the liver. DILI may develop in the context of an immunoallergic syndrome with cutaneous manifes- tations, which are sometimes severe ... -
Immunophenotyping to improve the mechanistic understanding of idiosyncratic drug-induced liver injury: clinical implications and future directions
Cueto Sánchez, Alejandro José; Di Zeo-Sánchez, Daniel Enrique; Segovia-Zafra, Antonio; Matilla-Cabello, Gonzalo; Bodoque-García, Ana; Lucena-González, María Isabel; Villanueva-Paz, Marina[et al.] (Open Exploration, 2023-04-26)
The late event onset of a fraction of idiosyncratic drug-induced liver injury (DILI) cases and the link observed by genome-wide association studies (GWASs) of certain human leucocyte antigen (HLA) alleles with DILI due to ... -
Modeling drug-induced liver injury: current status and future prospects.
Di Zeo-Sánchez, Daniel Enrique; Segovia-Zafra, Antonio; Matilla-Cabello, Gonzalo; Pinazo-Bandera, José; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Villanueva-Paz, Marina[et al.] (Taylor & Francis, 2022-09-16)
Introduction Idiosyncratic drug-induced liver injury (iDILI) is a challenging and unpredictable multifactorial condition. At present, validated preclinical models for the prediction of the hepatotoxic potential of a given ... -
Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction
Segovia-Zafra, Antonio; Di Zeo-Sánchez, Daniel Enrique; López-Gómez, Carlos; Pérez-Valdés, Zeus; García-Fuentes, Eduardo; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Villanueva-Paz, Marina[et al.] (Elsevier, 2021-12)
Idiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that pre- scription and non-prescription drugs, herbal and dietary supplements can cause to the liver. iDILI remains a major public health ... -
Recreational Drugs and the Risk of Hepatocellular Carcinoma
Pinazo-Bandera, José M.; García-Cortés, Miren; Segovia-Zafra, Antonio; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús (IOAP-MPDI, 2022-11-02)
Hepatocellular carcinoma represents an important contributor to the global cancer-related burden, and liver cirrhosis is the main risk factor for its development. Conventional or illegal drug consumption is a potential but ...