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Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis.
Meçe, Odeta; Houbaert, Diede; Sassano, Maria-Livia; Durré, Tania; Maes, Hannelore; Schaaf, Marco; More, Sanket; Ganne, Maarten; García-Caballero, Melissa; Born, Mila; Verhoeven, Jelle; Agrawal, Madhur; Jacobs, Kathryn; Bergers, Gabriele; Blacher, Silvia; Ghesquière, Bart; Dewerchin, Mieke; Swinnen, Johan V.; Vinckier, Stefan; Soengas, María S.; Carmeliet, Peter; Noël, Agnès; Agostinis, Patrizia[et al.] (SpringerNature, 2022-05-19)Autophagy has vasculoprotective roles, but whether and how it regulates lymphatic endothelial cells (LEC) homeostasis and lymphangiogenesis is unknown. Here, we show that genetic deficiency of autophagy in LEC impairs ... -
Metabolic Reprogramming in Tumor Endothelial Cells.
García-Caballero, Melissa; Sokol, Liliana; Cuypers, Anne; Carmeliet, Peter (MDPI, 2022-09-21)The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical ...