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Listar por autor "Medina-Luque, José"
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Dopamine D4 receptor activation counteracts nigrostriatal pathway activation by morphine: relevance in drug addiction.
Rivera-Ramírez, Alicia; Suárez-Boomgaard, Diana; Gago-Calderón, Belén; Valderrama-Carvajal, Alejandra; Medina-Luque, José; Roales-Buján, Ruth; Fuxe, Kjell; De-la-Calle-Martín, Adelaida[et al.] (2013)Morphine induces dopamine release in the caudate putamen (CPu), which promotes stereotyped behavior and habit learning for drug-seeking and –taking. Nigrostriatal pathway stimulation by morphine is due to a removal of tonic ... -
Dopamine D4 receptor counteracts morphine-induced changes in M opioid receptor signaling in the striosomes of the rat caudate putamen.
Rivera-Ramírez, Alicia; Valderrama-Carvajal, Alejandra; Roales-Buján, Ruth; Suárez-Boomgaard, Diana; Medina-Luque, José; Shumilov, Kirill; De-la-Calle-Martín, Adelaida[et al.] (2015-10-05)Morphine is one of the most potent analgesic drugs used to relieve moderate to severe pain. After long-term use of morphine, neuroadaptive changes in the brain promotes tolerance, which result in a reduced sensitivity to ...