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Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism
Mukherjee, Abhisek; Morales-Scheihing, Diego; Salvadores, Natalia; Moreno-Gonzalez, Ines; Gonzalez, Cesar; Taylor-Presse, Kaithlyn; Mendez, Nicolas; Shahnawaz, Mohamed; Gaber, Ahmed Osama; Sabek, Omaima; Fraga, Daniel W; Soto, Claudio[et al.] (Rockefeller University PRess, 2017)Although a large proportion of patients with type 2 diabetes (T2D) accumulate misfolded aggregates composed of the islet amyloid polypeptide (IAPP), its role in the disease is unknown. Here, we show that pancreatic IAPP ...