Listar por autor "García-Bonilla, María"
Mostrando ítems 1-14 de 14
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Bone marrow-derived mesenchymal stem cells characterization and transplantation in an animal model of congenital hydrocephalus
García-Bonilla, María; Cifuentes-Rueda, Manuel
; Ho-Plágaro, Ailec; Santos-Ruiz, Leonor; Shumilov, Kirill; Pérez-Fígares, José Manuel; Jiménez-Lara, Antonio Jesús[et al.] (2015-10-08)
Congenital hydrocephalus is a disorder presenting a degeneration of the periventricular cerebral parenchyma and the white matter, which causes significant mortality and life-long neurological complications. There are ... -
Bone marrow-derived mesenchymal stem cells transplantation produces a tissue recovery in hydrocephalic mice
García-Bonilla, María; Shumilov, Kirill; Vitorica Ferrández, Javier; García-Martín, María Luisa; Muñoz, Carmen; Claros-Gil, Silvia; Gutiérrez-Pérez, Antonia; Jiménez-Lara, Antonio Jesús[et al.] (2018-07-25)
In congenital hydrocephalus, cerebrospinal fluid accumulation is associated to ischemia/hypoxia, metabolic impairment, neuronal damage and astrocytic reaction, which cause significant mortality and life-long neurological ... -
Brain tissue recovery in obstructive congenital hydrocephalus after intraventricular transplantation of mesenchymal stem cells
García-Bonilla, María; Ojeda-Pérez, Betsaida; Shumilov, Kirill; Vitorica Ferrández, Javier; García-Martín, María Luisa; Muñoz, Carmen; Gutiérrez-Pérez, Antonia; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia[et al.] (2018-10-29)
Introduction: Bone marrow-derived mesenchymal stem cells (BM-MSC) are a potential therapeutic tool due to their ability for migrating and producing neuroprotector factors when transplanted. The aim of this study was to ... -
Characterization and administration of bone marrow-derived mesenchymal stem cells in an animal model of congenital hydrocephalus
García-Bonilla, María; Cifuentes-Rueda, Manuel; Ho-Plágaro, Ailec; Shumilov, Kirill; Santos-Ruiz, Leonor; Pérez-Fígares, José Manuel; Jiménez-Lara, Antonio Jesús[et al.] (2015-07-08)
Bone marrow-derived mesenchymal stem cells (BM-MSC) are considered as a potential therapeutic tool in neurodegenerative diseases, due to their ability to migrate to degenerated tissues and the production of growth factors. ... -
Design of a Stem Cell-Based Therapy for Ependymal Repair in Hydrocephalus Associated With Germinal Matrix Hemorrhages
Rodríguez-Pérez, Luis Manuel; Ojeda-Pérez, Betsaida; López-de-San-Sebastián, Javier; García-Bonilla, María; González-García, Marcos; Fernandez-Muñoz, Beatriz; Sánchez Pernaute, Rosario; García-Martín, María L.; Domínguez-Pinos, Dolores; Cárdenas García, Casimiro; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia[et al.] (AHA/ASA Journals, 2024-04)
BACKGROUND: In preterm birth germinal matrix hemorrhages (GMHs) and the consequent posthemorrhagic hydrocephalus (PHH), the neuroepithelium/ependyma development is disrupted. This work is aimed to explore the possibilities ... -
Effect of bone marrow-derived mesenchymal stem cells on congenital hydrocephalus in the hyh mouse
García-Bonilla, María; Shumilov, Kirill; Vitorica Ferrández, Javier; García-Martín, María Luisa; Muñoz, Carmen; Jiménez, Sebastián; Navarro, Victoria; García-Cuervo, Luisa; Cifuentes-Rueda, Manuel; Claros-Gil, Silvia; Andrades-Gómez, José Antonio; Guitérrez, Antonia; Páez-González, Patricia; Jiménez-Lara, Antonio Jesús[et al.] (2017-06-28)
Background Bone marrow-derived mesenchymal stem cells (BM-MSC) are considered as a potential therapeutic tool for neurodegenerative diseases due to their ability for migrating into damaged tissue. Additionally, these cells ... -
Generation of periventricular reactive astrocytes overexpressing aquaporin 4 Is stimulated by mesenchymal stem cell therapy
García-Bonilla, María; Ojeda-Pérez, Betsaida; Shumilov, Kirill; Rodríguez-Pérez, Luis Manuel; Domínguez-Pinos, Dolores; Vitorica Ferrández, Javier; Jiménez, Sebastián; Ramírez-Lorca, Reposo; Echevarría, Miriam; Cárdenas García, Casimiro; Iglesias, Teresa; Gutiérrez-Pérez, Antonia; McAllister, James P. (II); Limbrick, David D. (Jr.); Páez-González, Patricia; Jiménez-Lara, Antonio Jesús[et al.] (MDPI, 2023-03-15)
Aquaporin-4 (AQP4) plays a crucial role in brain water circulation and is considered a therapeutic target in hydrocephalus. Congenital hydrocephalus is associated with a reaction of astrocytes in the periventricular white ... -
Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus
Ojeda-Pérez, Betsaida; Campos-Sandoval, José Ángel; García-Bonilla, María; Cárdenas García, Casimiro; Páez-González, Patricia; Jiménez-Lara, Antonio Jesús[et al.] (BMC, 2021)
Periventricular extracellular oedema, myelin damage, inflammation, and glial reactions are common neuropathological events that occur in the brain in congenital hydrocephalus. The periventricular white matter is the most ... -
Long-time effects of an experimental therapy with mesenchymal stem cells in congenital hydrocephalus
García-Bonilla, María; Ojeda-Pérez, Betsaida; Shumilov, Kirill; Vitorica Ferrández, Javier; Guitérrez, Antonia; Páez-González, Patricia; Jiménez-Lara, Antonio Jesús[et al.] (2019-07-03)
Introduction: Bone marrow-derived mesenchymal stem cells (BM-MSC) are a potential therapeutic tool due to their ability for migrating and producing neuroprotector factors when they are transplanted in other neurodegenerative ... -
A metabolite profile reveals the presence of neurodegenerative conditions according to severity of hydrocephalus
García-Bonilla, María; Shumilov, Kirill; García-Martín, María Luisa; Muñoz, María Carmen; Domínguez-Pinos, Dolores; Gutiérrez-Pérez, Antonia; Páez-González, Patricia; Jiménez-Lara, Antonio Jesús[et al.] (2018-11-29)
Introduction: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure (ICP), ischemia/hypoxia, metabolic impairment, neuronal damage and astrocytic reaction. ... -
Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells.
García-Bonilla, María; Ojeda-Pérez, Betsaida; García-Martín, María Luisa; Muñoz-Hernández, María del Carmen; Vitorica Ferrández, Javier; Jiménez, Sebastián; Cifuentes-Rueda, Manuel; Santos-Ruiz, Leonor; Shumilov, Kirill; Claros-Gil, Silvia; Gutiérrez-Pérez, Antonia; Páez-González, Patricia[et al.] (BMC, 2020-03-17)
In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial ... -
NG2 cells in an animal model of congenital hydrocephalus
Jiménez-Lara, Antonio Jesús; Ojeda-Pérez, Betsaida; García-Bonilla, María; Ruz-Maldonado, Inmaculada; Mateos-Grondona, Jesús; Rodríguez-Pérez, Luis Manuel; Páez-González, Patricia[et al.] (2017-06-28)
NG2 cells are considered oligodendrocyte precursor cells (OPC). In pathological conditions, NG2 cells contribute to generate oligodendrocytes and reactive astrocytes. This study has been designed to uncover the role of NG2 ... -
Orientación y mejora de competencias de comunicación a través del análisis crítico entre estudiantes de Trabajo Fin de Grado
Arrojo-Agudo, María Ángeles; Pascual, Mª Belén; Flores-Burgess, Antonio; De-la-Torre-Fazio, Fernando Nicolás; García-Bonilla, María; Jiménez-Lara, Antonio Jesús; Moreno-Ostos, Enrique; Sesmero-Carrasco, Rafael Enrique[et al.] (2019-07-05)
El Trabajo Fin de Grado (TFG), asignatura obligatoria que el estudiante debe realizar autónoma e individualmente, es un trabajo original que será presentado y defendido ante un Tribunal de Evaluación. Su implantación ha ... -
Potential protective role of reactive astrocytes in the periventricular parenchyma in congenital hydrocephalus
García-Bonilla, María; Shumilov, Kirill; Peñalver, Ana; Castilla, Laura; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; García-Martín, María Luisa; Muñoz, Carmen; Gutiérrez-Pérez, Antonia; Jiménez-Lara, Antonio Jesús[et al.] (2016-07-11)
Background Cerebrospinal fluid accumulation in hydrocephalus produces an elevation of intraventricular pressure with pathological consequences on the periventricular brain parenchyma including ischemia, oedema, oxidative ...