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Listar por autor "Gauthier, Benoit R."
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Abnormal cannabidiol ameliorates inflammation preserving pancreatic beta cells in mouse models of experimental type 1 diabetes and beta cell damage
González-Mariscal, Isabel; Pozo-Morales, Macarena; Romero-Zerbo, Silvana Yanina; Espinosa-Jiménez, Vanesa; Escamilla-Sánchez, Alejandro; Sánchez-Salido, Lourdes; Cobo-Vuilleumier, Nadia; Gauthier, Benoit R.; Bermúdez Silva, Francisco Javier[et al.] (Elsevier, 2021-12-03)The atypical cannabinoid Abn-CBD improves the inflammatory status in preclinical models of several pathologies, including autoimmune diseases. However, its potential for modulating inflammation in autoimmune type 1 diabetes ... -
LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
Cobo-Vuilleumier, Nadia; Lorenzo, Petra I; García Rodríguez, Noelia; Herrera Gómez, Irene de Gracia; Fuente-Martin, Esther; López-Noriega, Livia; Mellado-Gil, José Manuel; Romero-Zerbo, Silvana Yanina; Baquié, Mathurin; Lachaud, Christian Claude; Stifter, Katja; Perdomo, German; Bugliani, Marco; De Tata, Vincenzo; Bosco, Domenico; Parnaud, Geraldine; Pozo, David; Hmadcha, Abdelkrim; Florido, Javier P; Toscano, Miguel G; de Haan, Peter; Schoonjans, Kristina; Sánchez Palazón, Luis; Marchetti, Piero; Schirmbeck, Reinhold; Martín-Montalvo, Alejandro; Meda, Paolo; Bernat, Soria; Bermúdez Silva, Francisco Javier; St-Onge, Luc; Gauthier, Benoit R[et al.] (Nature Research, 2018)Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited ... -
The Atypical Cannabinoid Abn-CBD Reduces Inflammation and Protects Liver, Pancreas, and Adipose Tissue in a Mouse Model of Prediabetes and Non-alcoholic Fatty Liver Disease
Romero-Zerbo, Silvana Yanina; García-Fernández, María Inmaculada; Espinosa-Jiménez, Vanesa; Pozo-Morales, Macarena; Escamilla-Sánchez, Alejandro; Sánchez-Salido, Lourdes; Lara, Estrella; Cobo-Vuilleumier, Nadia; Rafacho, Alex; Olveira-Fuster, Gabriel María; Rojo-Martínez, Gemma; Gauthier, Benoit R.; González-Mariscal, Isabel; Bermúdez Silva, Francisco Javier[et al.] (Frontiers, 2020-03-06)Background and Aims: The synthetic atypical cannabinoid Abn-CBD, a cannabidiol (CBD) derivative, has been recently shown to modulate the immune system in different organs, but its impact in obesity-related meta-inflammation ...