Listar por autor "Verfaillie, Catherine M."
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Fast and efficient generation of oligodendrocytes from human induced pluripotent stem cells (hiPSCs)
García-León, Juan Antonio
; Cáceres Palomo, Laura; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Verfaillie, Catherine M.; Gutiérrez-Pérez, Antonia[et al.] (Wiley, 2021-07)
Oligodendrocytes (OLs) are highly specialized cells of the central nervous system responsible for myelin production and metabolic support of neurons. Defects in OLs are crucial in several neurodegenerative diseases including ... -
Genetically Engineered Triple MAPT-Mutant Human-Induced Pluripotent Stem Cells (N279K, P301L, and E10+16 Mutations) Exhibit Impairments in Mitochondrial Bioenergetics and Dynamics.
Szabo, Leonora; Grimm, Amandine; García-León, Juan Antonio; Verfaillie, Catherine M.; Eckert, Anne (MDPI, 2023-05-13)
Pathological abnormalities in the tau protein give rise to a variety of neurodegenerative diseases, conjointly termed tauopathies. Several tau mutations have been identified in the tau-encoding gene MAPT, affecting either ... -
In vitro modeling of dysfunctional glial cells in neurodegenerative diseases using human pluripotent stem cells
García-León, Juan Antonio; Eggermont, K; Neyrinck, K; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Verfaillie, Catherine M.; Gutiérrez-Pérez, Antonia[et al.] (2019-07-26)
Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable models, have precluded the development of effective therapies counteracting ... -
Stem Cell-Derived Oligodendroglial Cells for Therapy in Neurological Diseases.
García-León, Juan Antonio; Verfaillie, Catherine M. (Bentham Science, 2016-07)
There are an important number of neurological diseases where not neurons but glia are the responsible cells for the degeneration of the nervous system. In the last years, determinant roles for oligodendrocytes (OLs) have ...