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PGC-1 alpha activates CYP7A1 and bile acid biosynthesis
Shin, Dong-Ju; Campos-Sandoval, José Ángel; Gil, Gregorio; Osborne, Timothy F. (American Society for Biochemistry and Molecular Biology, 2003)
Cholesterol 7-alpha-hydroxylase (CYP7A1) is the key enzyme that commits cholesterol to the neutral bile acid biosynthesis pathway and is highly regulated. In the current studies, we have uncovered a role for the transcriptional ...