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Listar por autor "Ashby, Kristin"
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Drug properties and host factors contribute to biochemical presentation of drug-induced liver injury: a prediction model from a machine learning approach
González-Jiménez, Andrés; Suzuki, Ayako; Chen, Minjun; Ashby, Kristin; Alvarez-Alvarez, Ismael; Andrade-Bellido, Raúl Jesús
; Lucena-González, María Isabel[et al.] (Springer, 2021-03-05)
Drug-induced liver injury (DILI) presentation varies biochemically and histologically. Certain drugs present quite consistent injury patterns, i.e., DILI signatures. In contrast, others are manifested as broader types of ... -
Elevated bilirubin, alkaline phosphatase at onset, and drug metabolism are associated with prolonged recovery from DILI.
Ashby, Kristin; Zhuang, Wei; González-Jiménez, Andrés; Alvarez-Alvarez, Ismael; Lucena, M. Isabel; Andrade-Bellido, Raúl Jesús; Aithal, Guruprasad P.; Suzuki, Ayako; Chen, Minjun[et al.] (Elsevier, 2021)
Background & aims: Although most drug-induced liver injury (DILI) cases resolve after the offending medication is discontinued, time to recovery varies among patients, with 6 -12% developing a chronic disease. Herein, we ...