Listar por autor "Mejías-Ortega, Marina"
Mostrando ítems 1-20 de 20
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Astroglial reactivity in response to b-amyloidosis is associated with mithocondrial pathology in the hippocampus of Alzheimer's transgenic mice
López Oliva, Elba; Trujillo-Estrada, Laura Isabel
; Sánchez-Mejías, Elisabeth; Mejías-Ortega, Marina; Fernández-Valenzuela, Juan José; Gómez-Arboledas, Ángela; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023-04)
Aims: Alzheimer’s diseaase (A)D is associated with early energy hypometabolism, synaptic and mitochondrial dysfunction, oxidative stress, inflammation, abnormal proteostasis and progressive neurodegeneration. During the ... -
Coexistance of different damage-associated myeloid populations in the hippocampus of Alzheimer's patients
Sánchez-Mejías, Elisabeth; Mejías-Ortega, Marina; Dávila-Cansino, José Carlos; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier (Wiley, 2021)
Parenchymal microglia are the brain-resident immune cells capable of responding to damage. Though the role of microglial cells in the development/progression of AD is still unknown, a dysfunctional response has recently ... -
Coexistance of different myeloid populations in the frontal cortex of alzheimer's disease patients
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Trujillo-Estrada, Laura Isabel; Sánchez-Varo, Raquel María; Dávila-Cansino, José Carlos; Dávila-Cansino, José Carlos; Gutiérrez-Pérez, Antonia[et al.] (2020-12-16)
Parenchymal microglia, the brain-resident immune cells capable of responding to damage and disease, has been postulated as a critical factor in the Alzheimer´s disease (AD) progression. Apart from microglia, CNS macrophages, ... -
Comparing astroglial reactivity in two transgenic mouse models of tauopathy
Fernández-Valenzuela, Juan José; Sanchez Varo, Raquel; López Oliva, Elba; Romero Molina, Carmen; Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2021-11-03)
Astrocytes are becoming crucial players in the pathology of neurodegenerative disorders, such as Alzheimer’s disease (AD). Astrocyte responses have been mainly analyzed in the context of amyloid-beta (Abeta) pathology, ... -
Decoding damage-associated microglia in post mortem hippocampus of Alzheimer’s disease patients
Sánchez-Mejías, Elisabeth; Mejías-Ortega, Marina; Navarro, Victoria; Gómez-Arboledas, Ángela; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2019-07-18)
The relationship between Alzheimer’s disease (AD) and neuroinflammation has become stronger since the identification of several genetic risk factors related to microglial function. Though the role of microglial cells in ... -
Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients
Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Gómez-Arboledas, Ángela; García-León, Juan Antonio; Fernández-Valenzuela, Juan José; Mejías-Ortega, Marina; Trujillo-Estrada, Laura Isabel; Baglietto-Vargas, David; Moreno-González, Inés; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Wiley, 2020-03)
Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer's disease (AD). Defective GABAergic neuronal functions may lead to cortical network hyperactivity and ... -
Diversity of plaque-associated myeloid cells subtypes in human alzheimer’s disease brain
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Muñoz-Castro, Clara; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2022)
Aims: Parenchymal microglia, as well other myeloid cells, have been postulated as a critical factor in Alzheimer´s disease (AD) pathogenesis since the identification of genetic risk factors related to their functions. ... -
Heterogeneidad regional de la respuesta microglial asociada a la patología amiloide en la enfermedad de Alzheimer.
(UMA Editorial, 2024)La enfermedad de Alzheimer (AD), principal causa de demencia y discapacidad, es la patología neurodegenerativa más prevalente en los mayores de 65 años y para la cual no existe un tratamiento efectivo. Se trata de una ... -
Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer’s Disease.
García-León, Juan Antonio; Cáceres Palomo, Laura; Sánchez-Mejías, Elisabeth; Mejías-Ortega, Marina; Núñez-Díaz, Cristina; Fernández-Valenzuela, Juan José; Sánchez-Varo, Raquel María; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (MDPI, 2020-09-18)
Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tangles are prime features of Alzheimer’s disease (AD). The pathology of AD is very complex and still not fully understood, since different ... -
Involvement of different aβ-associated myeloid populations in the human alzheimer’s brain
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Muñoz-Castro, Clara; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2022)
Parenchymal microglia, the brain-resident immune cells, have been postulated as a critical factor in Alzheimer´s disease (AD) since the identification of genetic risk factors related to their functions. Though the role of ... -
Microglial responses in the human Alzheimer’s disease frontal cortex
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Sánchez-Varo, Raquel María; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2019-07-17)
The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for this pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial ... -
Mitochondrial ultrastructural defects in reactive astrocytes of Alzheimer's mice hippocampus.
Trujillo-Estrada, Laura Isabel; López Oliva, Elba; Fernández-Valenzuela, Juan José; Sánchez-Mejías, Elisabeth; Mejías-Ortega, Marina; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Alzheimer's disease (AD) is a complex neurodegenerative condition that causes progressive memory loss and dementia. In AD brains astrocyte become reactive potentially contributing to cognitive decline. Astrocyte reactivity ... -
Monocyte-derived cells invade amyloid plaques in human alzheimer’s disease hippocampus.
Mejías-Ortega, Marina; Muñoz-Castro, Clara; Sánchez-Mejías, Elisabeth; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Microglia, the brain-resident myeloid cells, play a major role in the immune responses of the nervous system and in the pathogenesis of Alzheimer's disease (AD). However, the presence of peripheral myeloid cells in the AD ... -
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus.
Muñoz-Castro, Clara; Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Trujillo-Estrada, Laura Isabel; Jimenez, Sebastian; García-León, Juan Antonio; Fernández-Valenzuela, Juan José; Sanchez-Mico, María Virtudes; Romero-Molina, Carmen; Moreno-González, Inés; Baglietto-Vargas, David; Marisa, Vizuete; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Biomed Central Ltd, 2023-02-28)
Microglia play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer’s disease (AD). However, the contribution of nonparenchymal or brain‑infiltrated myeloid cells to disease progression ... -
Peripheral myeloid cells infiltrate the hippocampus of Alzheimer's disease patients.
Mejías-Ortega, Marina; Muñoz-Castro, Clara; Sánchez-Mejías, Elisabeth; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Microglia, the brain-resident myeloid cells, play a major role in the immune responses of the nervous system and in the pathogenesis of Alzheimer's disease (AD). However, the presence of peripheral myeloid cells in the AD ... -
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Fernández-Valenzuela, Juan José; De Castro Carratalá, Vanessa; Mejías-Ortega, Marina; Gómez-Arboledas, Ángela; Jimenez, Sebastian; Sanchez-Mico, Maria Virtudes; Trujillo-Estrada, Laura Isabel; Moreno-González, Inés; Baglietto-Vargas, David; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Frontiers, 2021-11-04)
Synaptic dysfunction and loss have been established as the pathological features that best correlate with the early cognitive decline in Alzheimer’s disease (AD). At the histopathological level, post mortem AD brains exhibit ... -
Tau pathology and astroglial reactivity: a comparative study of two mouse models of tauopathy
Fernández-Valenzuela, Juan José; López Oliva, Elba; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Romero, Carmen; Mejías-Ortega, Marina; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2022)
Objectives: Astrocytes are becoming crucial players in the context of neurodegenerative proteinopathies, such as Alzheimer’s disease (AD). Astroglial response has been mainly analyzed in amyloidogenic scenarios, but less ... -
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
Sánchez-Varo, Raquel María; Mejías-Ortega, Marina; Fernández-Valenzuela, Juan José; Núñez-Díaz, Cristina; Cáceres Palomo, Laura; Vegas-Gómez, Laura; Sánchez-Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Moreno-González, Inés; García-León, Juan Antonio; Vizuete, María Luisa; Vitorica Ferrández, Javier; Baglietto-Vargas, David; Gutiérrez-Pérez, Antonia[et al.] (IOAP-MPDI, 2022-05-12)
Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations ... -
Ultrastructural evidence of mitochondrial pathology in hippocampal reactive astrocytes of β-amyloidosis Alzheimer’s transgenic mice
López Oliva, Elba; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Mejías-Ortega, Marina; Fernández-Valenzuela, Juan José; Gómez-Arboledas, Ángela; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Cold Spring Harbor Laboratory, 2022)
Astrocytes, the most abundant non-neuronal cell type in the CNS, play essential roles in brain homeostasis and neuroprotection, including metabolic support, synaptic plasticity, cerebral blood flow and immunity. Many of ... -
Understanding microglial responses in the frontal cortex of alzheimer´s disease patients
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2021-03-09)
Microglial cells, the immune cells of the brain, and the neuroinflammatory process associated, have been postulated as a critical factor in AD pathogenesis, since the identification of genetic risk factors related ...