Listar por autor "Shahnawaz, Mohammad"
Mostrando ítems 1-3 de 3
-
Amyloid-b seeding and propagation processes in a hAb-KI model of Alzheimer's disease
Trujillo-Estrada, Laura Isabel
; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Cheung, Alwin; Pham Tran, Janine; Núñez-Díaz, Cristina; Forner, Stefania; Martini, Alessandra C.; Da Cunha, Celia; Shahnawaz, Mohammad; Soto, Claudio; Moreno-González, Inés; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2020-12-17)
Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.
(Springer Nature, 2021-04-23)The majority of Alzheimer’s disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant ... -
Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding
(Springer Nature, 2017)Numerous epidemiological studies have shown a significantly higher risk for development of Alzheimer's disease (AD) in patients affected by type 2 diabetes (T2D), but the molecular mechanism responsible for this association ...