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Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice
Carmona, R; Cañete, A; Cano, E; Ariza, L; Rojas, A; Muñoz-Chápuli, R[et al.] (Elife, 2016-09)Congenital diaphragmatic hernia (CDH) is a severe birth defect. Wt1-null mouse embryos develop CDH but the mechanisms regulated by WT1 are unknown. We have generated a murine model with conditional deletion of WT1 in the ... -
Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis
Cañete, A; Cano, E; Muñoz-Chápuli, R; Carmona, R (MDPI, 2017-02)Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic ...