Listar por autor "Labella Vera, Alejandro Manuel"
Mostrando ítems 1-20 de 32
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An Efficient Machine Learning Method to Identify Genetic Drivers of Avian Influenza Virus Adaptation to Humans
Leiva Rebollo, Rocío; Patiño Galindo, Juan; Villalon Letelier, Fernando; Mena, Nacho; Tansey, W; Park, K; Labella Vera, Alejandro Manuel; Castro-López, María Dolores
; Borrego-García, Juan José; Rabadán, Raúl; García Sastre, Adolfo[et al.] (2024-09-02)
In this work we developed a method, based on a logistic regression model, to identify mutations subject to directional selection. We tested the model analyzing thousands of AIV (H5N1, H7N9) sequences from public datasets, ... -
Análisis de la expresión de inmunogenes en doradas vacunadas en respuesta a la infección por LCDV-Sa
Leiva-Rebollo, Rocío; Gémez-Mata, Juan; Labella Vera, Alejandro Manuel; Castro-López, María Dolores; Borrego-García, Juan José (2021)
El objetivo del presente estudio ha sido evaluar la respuesta inmune frente a la infección por Lymphocystis Disease Virus 3 (LCDV-Sa) en ejemplares de dorada (Sparus aurata) vacunados con un plásmido que codifica la proteína ... -
Desarrollo de un chip de DNA para la detección de dianas génicas bacterianas de interés en el campo de la acuicultura
Labella Vera, Alejandro Manuel; Trento, I.; Ghidini, V.; Gennari, M.; Castro-López, María Dolores; Borrego-García, Juan José; Lleò, M.M.[et al.] (2014-10-07)
La adquisición bacteriana de multiresistencias frente a antimicrobianos es un fenómeno cada vez más preocupante, con gran repercusión para la salud pública, pero también con impacto en sectores de la producción animal, ... -
Desarrollo de una vacuna DNA para el control de la enfermedad de linfocistis
Leiva, Rocío; Borrego-García, Juan José; Castro-López, María Dolores; Labella Vera, Alejandro Manuel (2018-06-20)
El virus de la enfermedad de linfocistis (LCDV) es el agente etiológico de la enfermedad de linfocistis, que afecta tanto a peces marinos como dulceacuícolas. Esta enfermedad supone un grave problema para el sector de la ... -
Desarrollo y evaluación de una vacuna DNA contra el virus de la enfermedad de linfocistis (LCDV)
Leiva, Rocío; Labella Vera, Alejandro Manuel; Castro-López, María Dolores; Borrego-García, Juan José (2018-10-23)
El virus de la enfermedad de linfocistis (LCDV) infecta tanto a peces marinos como dulceacuícolas, produciendo una patología que supone un grave problema para la acuicultura debido a las pérdidas económicas asociadas a su ... -
Detección y cuantificación del virus de la enfermedad de linfocistis mediante ensayo ICC-RT-PCR (integrated cell culture-RT-PCR)
Jiménez Valverde, Estefanía; Leiva, Rocío; Labella Vera, Alejandro Manuel; Borrego-García, Juan José; Castro-López, María Dolores (2015-07-21)
La enfermedad de linfocistis es la enfermedad de etiología viral más frecuentemente detectada en la acuicultura marina europea, siendo la principal patología de origen vírico descrita en doradas cultivadas. El agente ... -
Evaluación de la respuesta inmune en doradas tras la administración de una vacuna inactivada frente a betanodavirus
Gémez-Mata, Juan; Leiva-Rebollo, Rocío; Moreno, Patricia; Borrego-García, Juan José; García-Rosado, Esther; Labella Vera, Alejandro Manuel; Castro-López, María Dolores[et al.] (2023)
El virus de la necrosis nerviosa (VNN), género Betanodavirus, familia Nodaviridae, es el agente etiológico de la necrosis nerviosa viral, enfermedad que afecta a peces cultivados en todo el mundo. Existen cuatro especies ... -
Evaluación de la respuesta inmune en lenguado senegalés conferida por una vacuna inactivada frente a Betanodavirus
Gémez-Mata, Juan; Leiva-Rebollo, Rocío; López-Vázquez, Carmen; Olveira, José G.; Bandín Matos, Isabel; Borrego-García, Juan José; Castro-López, María Dolores; Labella Vera, Alejandro Manuel[et al.] (2022)
La necrosis nerviosa viral es una enfermedad que afecta a peces cultivados en todo el mundo. Su agente etiológico es el virus de la necrosis nerviosa, género Betanodavirus, familia Nodaviridae, que presenta un genoma ... -
Evaluation of gilthead seabream (Sparus aurata) immune response after LCDV DNA vaccination
Leiva-Rebollo, Rocío; Castro-López, María Dolores; Borrego-García, Juan José; Labella Vera, Alejandro Manuel (2019-10-07)
A DNA vaccine against Lymphocystis Disease Virus (LCDV) was developed and its protective efficacy in gilthead seabream (Sparus aurata) has been established. The aim of the present study is the evaluation of immune-related ... -
Evaluation of Gilthead Seabream (Sparus aurata) Immune Response after LCDV-Sa DNA Vaccination
Leiva Rebollo, Rocío; Castro-López, María Dolores; Moreno García, Patricia; Borrego-García, Juan José; Labella Vera, Alejandro Manuel (MDPI, 2021-05-29)
Lymphocystis disease is the main viral pathology in gilthead seabream aquaculture. Currently, there are no treatments or vaccines to control this disease, thus our main goal was to construct a DNA vaccine that can be used ... -
Evaluation of immune response after LCDV-Sa infection in DNA-vaccinated gilthead seabream
Leiva-Rebollo, Rocío; Gémez-Mata, Juan; Castro-López, María Dolores; Borrego-García, Juan José; Labella Vera, Alejandro Manuel (2021)
The immune-related gene expression in vaccinated gilthead seabream after Lymphocystis Disease Virus 3 (LCDV-Sa) infection was analysed by using an OpenArray based on TaqMan qPCR. The DNA vaccine used in this study encodes ... -
Evaluation of the immune response in betanodavirus-vaccinated gilthead seabream.
Gémez-Mata, Juan; Leiva-Rebollo, Rocío; Moreno-García, Patricia; Bandín Matos, Isabel; Borrego-García, Juan José; Labella Vera, Alejandro Manuel; Castro-López, María Dolores[et al.] (2023)
An inactivated vaccine has been developed using a RGNNV/SJNNV reassortant strain isolated from Senegalese sole, which confers moderate protection against the homologous viral strain in sole juveniles. The aim of this study ... -
Fish Iridoviridae: infection, vaccination and immune response
Leiva Rebollo, Rocío; Labella Vera, Alejandro Manuel; Gémez Mata, Juan; Castro-López, María Dolores; Borrego García, Juan José (Springer Nature, 2024-07-15)
Each year, due to climate change, an increasing number of new pathogens are being discovered and studied, leading to an increase in the number of known diseases affecting various fish species in different regions of the ... -
Identification, resistance to antibiotics and biofilm formation of bacterial strains isolated from a reverse osmosis system of a drinking water treatment plant
Borrego García, Juan José; Labella Vera, Alejandro Manuel; Molero, Rosana; Leiva Rebollo, Rocío; Pérez-Recuerda, Rocío (Elsevier, 2021-02-04)
Membrane processes such as, reverse osmosis (RO), is one option for drinking water treatment where a high product quality is desired. RO membranes are able to effectively remove organic and inorganic compounds and ... -
Immune gene expression in gilthead seabream (Sparus aurata) after Lymphocystis disease virus (LCDV‐Sa) challenge resulting in asymptomatic infection
Leiva Rebollo, Rocío; Labella Vera, Alejandro Manuel; Borrego-García, Juan José; Castro-López, María Dolores (Oxford Academic, 2020-01-01)
Aims: To determine the immune gene expression response of gilthead seabream (Sparus aurata) that is experimentally infected with the lymphocystivirus LCDV-Sa. Methods and Results: Viral DNA and transcripts were detected ... -
Immune gene expression in gilthead seabream after nervous necrosis virus (NNV) challenge
Gémez-Mata, Juan; Leiva-Rebollo, Rocío; Moreno-García, Patricia; Bandín Matos, Isabel; Borrego-García, Juan José; Labella Vera, Alejandro Manuel; Castro-López, María Dolores[et al.] (2022-09)
Viral nervous necrosis (VNN) is a disease that affects farmed fish worldwide. Its etiologic agent is the nervous necrosis virus (NNV), genus Betanodavirus, family Nodaviridae. NNV are small and non-enveloped viruses with ... -
Immune response of DNA vaccinated-gilthead seabream against LCDV-Sa infection: relevance of the inflammatory process.
Leiva-Rebollo, Rocío; Gémez-Mata, Juan; Castro-López, María Dolores; Borrego-García, Juan José; Labella Vera, Alejandro Manuel (2023)
Lymphocystis disease is one of the main viral pathologies affecting cultured gilthead seabream in the Mediterranean area. Recently, we have developed a DNA-vaccine based on the major capsid protein of the Lymphocystis ... -
Immune response of gilthead seabream (Sparus aurata) after experimental infection with lymphocystis disease virus (LCDV-Sa)
Leiva-Rebollo, Rocío; Labella Vera, Alejandro Manuel; Castro-López, María Dolores; Borrego-García, Juan José (2019-07-29)
Lymphocystis disease (LCD) is caused by the lymphocystis disease virus (LCDV) (family Iridoviridae), affecting more than 150 fish species from both marine and freshwater environments. A few studies have been focused on the ... -
Immune response of gilthead seabream infected with wild and mutant nervous necrosis virus reassortants.
Gémez-Mata, Juan; Leiva-Rebollo, Rocío; Moreno-García, Patricia; Borrego-García, Juan José; Labella Vera, Alejandro Manuel; Castro-López, María Dolores[et al.] (2023)
Viral nervous necrosis (VNN) is a disease that affects farmed fish worldwide. Its etiologic agent is the nervous necrosis virus currently classified into 4 species: SJNNV, RGNNV, TPNNV and BFNNV. In Southern Europe, ... -
Immune response of Senegalese sole and gilthead seabream after vaccination with an inactivated vaccine against betanodavirus.
Gémez-Mata, Juan; Leiva-Rebollo, Rocío; Moreno-García, Patricia; Bandín Matos, Isabel; Borrego-García, Juan José; Labella Vera, Alejandro Manuel; Castro-López, María Dolores[et al.] (2024)
Nervous necrosis virus (NNV) (genus Betanodavirus, family Nodaviridae) is the etiologic agent of viral encephalopathy and retinopathy (VER). This virus is classified into four species: SJNNV, RGNNV, TPNNV and BFNNV. In ...