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Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration
García-León, Juan Antonio; Cabrera-Socorro, Alfredo; Eggermont, Kristel; Swijsen, Ann; Terryn, Joke; Fazal, Raheem; Nami, FatemehArefeh; Ordovás, Laura; Quiles, Ana; Lluis, Frederic; Serneels, Lutgarde; Wierda, Keimpe; Sierksma, Annerieke; Kreir, Mohamed; Pestana, Francisco; Van Damme, Philip; De Strooper, Bart; Thorrez, Lieven; Ebneth, Andreas; Verfaillie, Catherine M[et al.] (Wiley, 2018-10)Introduction Tauopathies are neurodegenerative diseases characterized by TAU protein–related pathology, including frontotemporal dementia and Alzheimer's disease among others. Mutant TAU animal models are available, but ...