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Listar por autor "Orengo, Christine"
Mostrando ítems 1-9 de 9
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A comparison of RNA-seq and exon arrays for whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat
Perkins, James R; Antunes-Martins, Ana; Calvo, Margarita; Grist, John; Rust, Werner; Schmid, Ramona; Hildebrandt, Tobias; Kohl, Matthias; Orengo, Christine A.; McMahon, Stephen B; Bennett, David LH[et al.] (SAGE Publications, 2014-01-28)The past decade has seen an abundance of transcriptional profiling studies of preclinical models of persistent pain, predominantly employing microarray technology. In this study we directly compare exon microarrays to ... -
Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination
Fricker, Florence R; Antunes-Martins, Ana; Galino, Jorge; Paramsothy, Remi; La Russa, Federica; Perkins, James; Goldberg, Rebecca; Brelstaff, Jack; Zhu, Ning; McMahon, Stephen B; Orengo, Christine; Garratt, Alistair N; Birchmeier, Carmen; Bennett, David LH; Perkins[et al.] (Oxford University Press, 2013-07)Neuregulin 1 acts as an axonal signal that regulates multiple aspects of Schwann cell development including the survival and migration of Schwann cell precursors, the ensheathment of axons and subsequent elaboration of the ... -
CXCL5 mediates UVB irradiation-induced pain.
Dawes, John M; Calvo, Margarita; Perkins, James Richard; Paterson, Kathryn J; Kiesewetter, Hannes; Hobbs, Carl; Kaan, Timothy K.Y.; Orengo, Christine A.; Bennett, David LH; McMahon, Stephen B[et al.] (AAAS, 2011-07-06)Many persistent pain states (pain lasting for hours, days, or longer) are poorly treated because of the limitations of existing therapies. Analgesics such as nonsteroidal anti-inflammatory drugs and opioids often provide ... -
Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis
Lees, Jonathan; Yeats, Corin; Perkins, James Richard; Sillitoe, Ian; Rentzsch, Robert; Dessailly, Benoit H; Orengo, Christine A.[et al.] (Oxford University Press, 2012-01)Gene3D http://gene3d.biochem.ucl.ac.uk is a comprehensive database of protein domain assignments for sequences from the major sequence databases. Domains are directly mapped from structures in the CATH database or predicted ... -
KinFams: De-Novo Classification of Protein Kinases Using CATH Functional Units
Adeyelu, Tolulope; Bordin, Nicola; Waman, Vaishali P.; Sadlej, Marta; Sillitoe, Ian; Moya-García, Aurelio Ángel; Orengo, Christine A.[et al.] (IOAP-MDPI, 2023-02-02)
Protein kinases are important targets for treating human disorders, and they are the second most targeted families after G-protein coupled receptors. Several resources provide classification of kinases into evolutionary ... -
PainNetworks: A web-based resource for the visualisation of pain related genes in the context of their network associations.
Perkins, James Richard; Lees, Jonathan; Antunes-Martins, Ana; Diboun, Ilhem; Mcmahon, Stephen B.; Bennett, David L. H.; Orengo, Christine A.[et al.] (IASP/Wolters Kluwer, 2013-08-11)We now know of hundreds of genes that have some association with pain. Several genes have been shown to alter pain sensitivity in humans, and can be found in the OMIM database. The Pain Gene Database gives details of genes ... -
ReadqPCR and NormqPCR: R packages for the reading, quality checking and normalisation of RT-qPCR quantification cycle (Cq) data
Perkins, James Richard; Dawes, John M; McMahon, Steve B; Bennett, David LH; Orengo, Christine A.; Kohl, Matthias[et al.] (BMC, 2012-07)Background: Measuring gene transcription using real-time reverse transcription polymerase chain reaction (RT-qPCR) technology is a mainstay of molecular biology. Technologies now exist to measure the abundance of many ... -
Transcriptional profiling of dendritic cells in a mouse model of food-antigen induced anaphylaxis reveals the upregulation of multiple immune-related pathways.
Rodríguez, María José; Palomares, Francisca; Bogas, Gador; Torres-Jaén, María Josefa
; Díaz-Perales, Araceli; Rojo, Javier; Plaza Serón, María del Carmen; Rodríguez-Nogales, Alba; Orengo, Christine A.; Mayorga, Cristobalina; Perkins, James Richard[et al.] (Wiley, 2018-10-20)
Scope Much of our knowledge about gene expression during anaphylaxis comes from candidate gene studies. Despite their potential role, expression changes in dendritic cells (DCs) have not been studied in this context using ... -
Transient protein-protein interactions: structural, functional, and network properties
Perkins, James Richard; Diboun, Ilhem; Dessailly, Benoit H; Lees, Jonathan G; Orengo, Christine A. (Elsevier, 2010-10-13)Transient interactions, which involve protein interactions that are formed and broken easily, are important in many aspects of cellular function. Here we describe structural and functional properties of transient interactions ...