Listar por autor "Andrade-Bellido, Raúl Jesús"
Mostrando ítems 1-20 de 51
-
A new framework for advancing in drug-induced liver injury research. The Prospective European DILI Registry.
Bjornsson, Einar S.; Stephens, Camilla; Atallah, Edmond; Robles-Díaz, María Mercedes
; Alvarez-Alvarez, Ismael; Gerbes, Alexander L; Weber, Sabine; Stirnimann, Guido; Kullak-Ublick, Gerd A; Cortez-Pinto, Helena; Grove, Jane I.; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Aithal, Guruprasad P.[et al.] (Wiley, 2023)
Background & Aims: No multi-national prospective study of drug-induced liver injury (DILI) has originated in Europe. The design of a prospective European DILI registry, clinical features and short-term outcomes of the cases ... -
A revised electronic version of RUCAM for the diagnosis of DILI
Hayashi, Paul H.; Lucena-González, María Isabel; Fontana, Robert J.; Bjornsson, Einar S.; Aithal, Guruprasad P.; Barnhart, Huiman; González-Jiménez, Andrés; Yang, Qinghong; Gu, Jiezhun; Andrade-Bellido, Raúl Jesús; Hoofnagle, Jay H.[et al.] (Wiley, 2022)
Background and Aims: Roussel Uclaf Causality Assessment Method (RUCAM) for DILI has been hindered by subjectivity and poor reliability. We sought to improve the RUCAM using data from the Drug-Induced Liver Injury Network ... -
A revised electronic version of RUCAM for the diagnosis of DILI.
Hayashi, PH; Lucena-González, María Isabel; Fontana, RJ; Bjornsson, ES; Aithal, GP; Barnhart, H; González-Jiménez, Andrés; Yang, Q; Gu, J; Andrade-Bellido, Raúl Jesús; Hoofnagle, JH[et al.] (LIPPINCOTT WILLIAMS & WILKINS, 2022-07)
Roussel Uclaf Causality Assessment Method (RUCAM) for DILI has been hindered by subjectivity and poor reliability. We sought to improve the RUCAM using data from the Drug-Induced Liver Injury Network (DILIN) and the Spanish ... -
Assessment of drug-induced liver injury in clinical practice.
Jiménez-Lucena, Isabel; García-Cortés, Miren; Cueto-Galán, Raquel; López-Durán, José Luis; Andrade-Bellido, Raúl Jesús (Wiley, 2008)
Currently, pharmaceutical preparations are serious contributors to liver disease, with hepatotoxicity ranking as the most frequent cause for acute liver failure and postmarketing regulatory decisions. The diagnostic ... -
Biomarcadores en el Trasplante Hepático: Comportamiento de la Proteína C Reactiva y la Procalcitonina en el Postoperatorio Inmediato del Trasplante Hepático
(UMA Editorial, 2021-11-10)Introducción: el trasplante hepático (TOH) es una técnica compleja y susceptible de múltiples complicaciones entre las que destaca por su gravedad la disfunción aguda grave del injerto (DAG). Esta tesis explora en primer ... -
Clinical characteristics and outcome of drug-induced liver injury in the older patients: from the young-old to the oldest-old
Weersink, Rianne A.; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana; Robles-Díaz, María Mercedes; Ortega-Alonso, Aida; García-Cortés, Miren; Bonilla, Elvira; Niu, Hao; Soriano, German; Jiménez-Pérez, Miguel; Hallal, Hacibe; Blanco, Sonia; Kaplowitz, Neil; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Wiley, 2020-11-11)
Old patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver injury (DILI) cohorts. We sought for the distinctive characteristics of DILI in older patients across age groups. A total of ... -
Clinical presentation, causative drugs and outcome of patients with autoimmune features in two prospective DILI registries
García-Cortés, Miren; Ortega-Alonso, Aida; Matilla-Cabello, Gonzalo; Medina-Cáliz, Inmaculada; Castiella, Agustin; Conde, Isabel; Bonilla-Toyos, Elvira; Pinazo-Bandera, José M.; Hernandez, Nelia; Tagle, Martin; Nunes, Vinicius; Parana, Raymundo; Bessone, Fernando; Kaplowitz, Neil; Lucena-González, María Isabel; Alvarez-Alvarez, Ismael; Robles-Díaz, María Mercedes; Andrade-Bellido, Raúl Jesús[et al.] (Wiley, 2023)
Background & aims: Idiosyncratic drug-induced liver injury (DILI) with autoimmune features is a liver condition with laboratory and histological characteristics similar to those of idiopathic autoimmune hepatitis (AIH), ... -
Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry
Stephens, Camilla; Robles-Díaz, María Mercedes; Medina-Cáliz, Inmaculada; García-Cortés, Miren; Ortega-Alonso, Aida; Sanabria-Cabrera, Judith Adriana; González-Jiménez, Andrés; Alvarez-Alvarez, Ismael; Slim, Mahmoud; Jiménez-Pérez, Miguel; González-Grande, Rocío; Fernández, M. Carmen; Casado, Marta; Soriano, German; Roman, Eva; Hallal, Hacibe; Romero-Gomez, Manuel; Castiella, Agustin; Conde, Isabel; Prieto, Martin; Moreno-Planas, José María; Giraldez, Alvaro; Moreno-Sanfiel, J Miguel; Kaplowitz, Neil; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Elsevier, 2021-02-01)
Background & aims: Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis of 843 patients with DILI enrolled into ... -
Critical Review of Gaps in the Diagnosis and Management of Drug-Induced Liver Injury Associated with Severe Cutaneous Adverse Reactions
Villanueva-Paz, Marina; Niu, Hao; Segovia-Zafra, Antonio; Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Alvarez-Alvarez, Ismael; Sanabria-Cabrera, Judith Adriana[et al.] (MDPI, 2021-11-15)
Drug-induced liver injury (DILI) encompasses the unexpected damage that drugs can cause to the liver. DILI may develop in the context of an immunoallergic syndrome with cutaneous manifes- tations, which are sometimes severe ... -
Differential iNKT and T cells activation in non-alcoholic fatty liver disease and drug-induced liver injury.
Caballano-Infantes, Estefanía; García-García, Alberto; Lopez-Gomez, Carlos; Cueto-Sánchez, Alejandro; Robles-Díaz, María Mercedes; Ortega-Alonso, Aida; Martín-Reyes, Flores; Alvarez-Alvarez, Ismael; Arranz-Salas, Isabel María; Ruiz-Cabello, Francisco; Lucena-González, María Isabel; García-Fuentes, Eduardo; Andrade-Bellido, Raúl Jesús; García-Cortés, Miren[et al.] (MDPI, 2021-01-28)
Background: Non-alcoholic fatty liver disease (NAFLD) and idiosyncratic drug-induced liver injury (DILI) could share molecular mechanisms involving the immune system. We aimed to identify activation immunological biomarkers ... -
Drug properties and host factors contribute to biochemical presentation of drug-induced liver injury: a prediction model from a machine learning approach
González-Jiménez, Andrés; Suzuki, Ayako; Chen, Minjun; Ashby, Kristin; Alvarez-Alvarez, Ismael; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel[et al.] (Springer, 2021-03-05)
Drug-induced liver injury (DILI) presentation varies biochemically and histologically. Certain drugs present quite consistent injury patterns, i.e., DILI signatures. In contrast, others are manifested as broader types of ... -
Elevated bilirubin, alkaline phosphatase at onset, and drug metabolism are associated with prolonged recovery from DILI.
Ashby, Kristin; Zhuang, Wei; González-Jiménez, Andrés; Alvarez-Alvarez, Ismael; Lucena, M. Isabel; Andrade-Bellido, Raúl Jesús; Aithal, Guruprasad P.; Suzuki, Ayako; Chen, Minjun[et al.] (Elsevier, 2021)
Background & aims: Although most drug-induced liver injury (DILI) cases resolve after the offending medication is discontinued, time to recovery varies among patients, with 6 -12% developing a chronic disease. Herein, we ... -
Esteatohepatitis no alcohólica en población adulta con rasgos de síndrome metabólico
(Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)La esteatohepatitis no alcohólica (NASH) es la expresión hepática del síndrome metabólico. El NASH es una entidad de pronóstico poco conocido ya que la biopsia hepática (gold standard para el diagnóstico), se realiza en ... -
Estudio de la Microbiota Intestinal en pacientes con Síndrome Metabólico y Enfermedad Hepática Grasa No Alcohólica
(Servicio de Publicaciones y Divulgación Científica, 2016)Está claramente establecida la relación entre hígado graso y síndrome metabólico. El síndrome metabólico (SM) es un conjunto de alteraciones que identifican a los sujetos en riesgo de desarrollar diabetes y/o enfermedades ... -
Estudio de la supervivencia a largo plazo de los pacientes tratados con prótesis puente a la cirugía versus cirugía urgente en la neoplasia obstructiva maligna de colon izquierdo
(UMA Editorial, 2022-01-13)Análisis de supervivencia de los pacientes potencialmente curables que presentan neoplasia maligna obstructiva izquierda. Se compara la supervivencia de los pacientes tratados con protesis puente a la cirugía versus los ... -
Estudio de los fenómenos de autoinmunidad en la enfermedad hepática tóxica
(UMA Editorial, 2017)La hepatotoxicidad idiosincrásica (DILI) por xenobióticos (fármacos, hierbas o productos de herboristería) es probablemente una de las enfermedades hepáticas más desconcertante y compleja, con múltiples facetas y gran ... -
Evaluación de causalidad en hepatotoxicidad
García-Cortés, Miren (Universidad de Málaga, Servicio de Publicaciones, 2006)
La hepatotoxicidad es un problema de salud pública infranotificado debido a la ausencia de marcadores diagnósticos específicos. En las últimas décadas se han venido desarrollando distintos métodos diagnósticos en ... -
Evaluation of diagnostic and prognostic candidate biomarkers in drug-induced liver injury vs. other forms of acute liver damage
Cueto-Sánchez, Alejandro; Niu, Hao; Alvarez-Alvarez, Ismael; López-Longarela, Bárbara; Del Campo-Herrera, Enrique; Ortega-Alonso, Aida; García-Cortés, Miren; Pinazo-Bandera, José M.; Sanabria-Cabrera, Judith Adriana; Díaz-Monchón, Juan José; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Stephens, Camilla; Robles-Díaz, María Mercedes[et al.] (Wiley, 2023)
Aims Detection and characterization of idiosyncratic drug-induced liver injury (DILI) currently rely on standard liver tests, which are suboptimal in terms of specificity, sensitivity and prognosis. Therefore, DILI diagnosis ... -
Factores Psicológicos Asociados a la Enfermedad Inflamatoria Intestinal Crónica
(UMA Editorial, 2015)La Enfermedad Inflamatoria Intestinal consiste en una inflamación crónica del tracto digestivo caracterizada por periodos de remisión y brotes de actividad. Dado su carácter crónico, la impredecibilidad de su evolución y ... -
Genetic and Molecular Factors in Drug-Induced Liver Injury: A Review.
Pachkoria, K.; Lucena-González, María Isabel; Molokhia, Mariam; Cueto-Galán, Raquel; Serrano-Carballo, Alfonso; Carvajal, Alfonso; Andrade-Bellido, Raúl Jesús[et al.] (Bentham Science, 2007)
El diagnóstico de la lesión hepática inducida por medicamentos (DILI, por sus siglas en inglés) es desafiante y se basa en criterios diagnósticos complejos. DILI se clasifica en dos categorías principales: i) reacciones ...