Listar por autor "Pascual-Anaya, Juan"
Mostrando ítems 1-16 de 16
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Comparative analysis of Hmx expression and the distribution of neuronal somata in the trigeminal ganglion in lamprey and shark: insights into the homology of the trigeminal nerve branches and the evolutionary origin of the vertebrate jaw
(BMC, 2023-12-05)The evolutionary origin of the jaw remains one of the most enigmatic events in vertebrate evolution. The trigeminal nerve is a key component for understanding jaw evolution, as it plays a crucial role as a sensorimotor ... -
Evidence from cyclostomes for complex regionalization of the ancestral vertebrate brain.
(Nature Research, 2016)The vertebrate brain is highly complex, but its evolutionary origin remains elusive. Because of the absence of certain developmental domains generally marked by the expression of regulatory genes, the embryonic brain of ... -
Evolution of Cyclostome Hox Clusters
(CRC Press (Taylor & Francis Group, LLC), 2023-04-14)Hagfish and lampreys represent the only two lineages of agnathan (jawless) vertebrates that have survived to the present day, and both form the monophyletic group of cyclostomes, which is sister to the rest of the vertebrates, ... -
Evolution of Hox gene clusters in deuterostomes
(BMC, 2013-07-02)Hox genes, with their similar roles in animals as evolutionarily distant as humans and flies, have fascinated biologists since their discovery nearly 30 years ago. During the last two decades, reports on Hox genes from a ... -
Evolution of the nitric oxide synthase family in vertebrates and novel insights in gill development
(The Royal Society, 2022)Nitric oxide (NO) is an ancestral key signalling molecule essential for life and has enormous versatility in biological systems, including cardiovascular homeostasis, neurotransmission and immunity. Although our knowledge ... -
Evolution of the NLR gene family in vertebrates: insights into the origin of inflammasomes.
(2024)Nucleotide binding domain leucine rich repeat proteins (NLRs) are a family of intracellular pattern recognition receptors which play an important role in innate immune system; as well as the regulation of many other ... -
Gene expansion and retention leads to a diverse tyrosine kinase superfamily in amphioxus
(Oxford University Press, 2008)Tyrosine kinase (TK) proteins play a central role in cellular behavior and development of animals. The expansion of this superfamily is regarded as a key event in the evolution of the complex signaling pathways and gene ... -
Hagfish and lamprey Hox genes reveal conservation of temporal colinearity in vertebrates
(Springer Nature, 2018)Hox genes exert fundamental roles for proper regional specification along the main rostro-caudal axis of animal embryos. They are generally expressed in restricted spatial domains according to their position in the cluster ... -
Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences
(Springer Nature, 2024-03)Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and is often assumed to be causally associated with organismal innovations and radiations. The 2R hypothesis ... -
Implications of duplicated cis-regulatory elements in the evolution of metazoans: the DDI model or how simplicity begets novelty.
(Oxford Academic, 2009)The discovery that most regulatory genes were conserved among animals from distant phyla challenged the ideas that gene duplication and divergence of homologous coding sequences were the basis for major morphological changes ... -
Inner ear development in cyclostomes and evolution of the vertebrate semicircular canals
(Springer Nature, 2019)Jawed vertebrates have inner ears with three semicircular canals, the presence of which has been used as a key to understanding evolutionary relationships. Ostracoderms, the jawless stem gnathostomes, had only two canals ... -
The Amphioxus Hox Cluster: Characterization, Comparative Genomics, and Evolution.
(Wiley, 2008-03-19)The amphioxus Hox cluster is often viewed as ‘‘archetypal’’ for the chordate lineage. Here, we present a descriptive account of the 448 kb region spanning the Hox cluster of the amphioxus Branchiostoma floridae from Hox14 ... -
The draft genomes of softshell turtle and green sea turtle yield insights into the development and evolution of the turtle specific body plan
(2013-06)The unique anatomical features of turtles have raised unanswered questions about the origin of their unique body plan. We generated and analyzed draft genomes of the softshell turtle (Pelodiscus sinensis) and the green sea ... -
The evolutionary origins of chordate hematopoiesis and vertebrate endothelia
Pascual-Anaya, Juan; Albuixech-Crespo, Beatriz; Somorjai, Ildikó M. L.; Carmona-Mejías, Rita María
; Oisi, Yasuhiro; Álvarez, Susana; Kuratani, Shigeru; Muñoz-Chápuli-Oriol, Ramón; Garcia-Fernàndez, Jordi[et al.] (Elsevier, 2013-03-15)
The vertebrate circulatory system is the most complex vascular system among those of metazoans, with key innovations including a multi-chambered heart and highly specialized blood cells. Invertebrate vessels, on the other ... -
Thyroid and endostyle development in cyclostomes provides new insights into the evolutionary history of vertebrates
(BMC, 2022)The endostyle is an epithelial exocrine gland found in non‑vertebrate chordates (amphioxi and tunicates) and the larvae of modern lampreys. It is generally considered to be an evolutionary precursor of the thyroid gland ... -
Unexpectedly large number of conserved noncoding regions within the ancestral chordate Hox cluster
(Springer, 2008)The single amphioxus Hox cluster contains 15 genes and may well resemble the ancestral chordate Hox cluster. We have sequenced the Hox genomic complement of the European amphioxus Branchiostoma lanceolatum and compared it ...