Listar por autor "Eggermont, Kristel"
Mostrando ítems 1-3 de 3
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Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration
García-León, Juan Antonio
; Cabrera-Socorro, Alfredo; Eggermont, Kristel; Swijsen, Ann; Terryn, Joke; Fazal, Raheem; Nami, FatemehArefeh; Ordovás, Laura; Quiles, Ana; Lluis, Frederic; Serneels, Lutgarde; Wierda, Keimpe; Sierksma, Annerieke; Kreir, Mohamed; Pestana, Francisco; Van Damme, Philip; De Strooper, Bart; Thorrez, Lieven; Ebneth, Andreas; Verfaillie, Catherine M[et al.] (Wiley, 2018-10)
Introduction Tauopathies are neurodegenerative diseases characterized by TAU protein–related pathology, including frontotemporal dementia and Alzheimer's disease among others. Mutant TAU animal models are available, but ... -
Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells
García-León, Juan Antonio; Garcia Diaz, Beatriz; Eggermont, Kristel; Cáceres Palomo, Laura; Neyrinck, Katrien; Madeiro da Costa, Rodrigo; Dávila-Cansino, José Carlos; Baron Van Evercooren, Anne; Gutiérrez-Pérez, Antonia; Verfaille, Catherine M[et al.] (Springer Nature, 2020)
Oligodendrocytes (OLs) are responsible for myelin production and metabolic support of neurons. Defects in OLs are crucial in several neurodegenerative diseases including multiple sclerosis (MS) and amyotrophic lateral ... -
SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells.
García-León, Juan Antonio; Kumar, Manoj; Boon, Ruben; Chau, David; One, Jennifer; Wolfs, Esther; Eggermont, Kristel; Berckmans, Pieter; Gunhanlar, Nilhan; de Vrij, Femke; Lendemeijer, Bas; Pavie, Benjamin; Corthout, Nikky; Kushner, Steven A; Dávila-Cansino, José Carlos; Lambrichts, Ivo; Hu, Wei-Shou; Verfaillie, Catherine M[et al.] (Elsevier, 2018-02)
Scarce access to primary samples and lack of efficient protocols to generate oligodendrocytes (OLs) from human pluripotent stem cells (hPSCs) are hampering our understanding of OL biology and the development of novel ...