Listar por autor "Rosales, Tracy"
Mostrando ítems 1-4 de 4
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Glutaminase-2 Expression Induces Metabolic Changes and Regulates Pyruvate Dehydrogenase Activity in Glioblastoma Cells
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel
; Rosales, Tracy; Ko, Bookyung; Alonso, Francisco J.; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (MDPI, 2025-01-06)
Glutaminase controls the first step in glutaminolysis, impacting bioenergetics, biosynthesis and oxidative stress. Two isoenzymes exist in humans, GLS and GLS2. GLS is considered prooncogenic and overexpressed in many ... -
Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
De los Santos-Jiménez, Juan; Rosales, Tracy; Ko, Bookyung; Campos-Sandoval, José Ángel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (IOAP-MDPI, 2023-01-15)
Glioblastoma multiforme is the most common primary brain tumor. Unfortunately, it is also one of the cancer types that has the worst morbidity and mortality ratios, so new targets and treatments need to be found. The ... -
Metabolic changes upon GLS inhibition by CB-839 in glioma cell lines
Santos Jiménez, Juan de los; Rosales, Tracy; Ko, Bookyung; Márquez-Gómez, Javier; Berardinis, Ralph J. de; Mates-Sánchez, José Manuel[et al.] (2012-07-19)
Many tumors use Gln for both energy generation and as a biosynthetic precursor. Glutaminases (GAs) catalyze the first step of glutaminolysis by converting glutamine (Gln) into glutamate and ammonia in the mitochondria. In ... -
Metabolic impact of glutaminase isoenzymes modulation on glioma cell lines
De los Santos-Jiménez, Juan; Rosales, Tracy; Bookyung, Ko; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (2022)
Many tumors use glutamine for both energy generation and as a biosynthetic precursor. Glutaminases (GAs) catalyze the first step of glutaminolysis by converting glutamine (Gln) into glutamate and ammonia in the mitochondria. ...