Listar por autor "Pavón-Morón, Francisco Javier"
Mostrando ítems 1-20 de 25
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Antipsychotic Medication Influences the Discriminative Value of Acylethanolamides as Biomarkers of Substance Use Disorder.
Herrera-Imbroda, Jesús; Flores-López, María; Requena-Ocaña, Nerea; Araos Gómez, Pedro Fernando; Ropero, Jessica; García-Marchena, Nuria; Bordallo Aragón, Antonio; Suárez-Pérez, Juan
; Pavón-Morón, Francisco Javier; Serrano, Antonia; Mayoral Cleries, Fermín; Rodriguez-de-Fonseca, Fernando[et al.] (MDPI, 2023-05-27)
Plasma acylethanolamides (NAEs), including the endocannabinoid anandamide (AEA), have been proposed as circulating biomarkers of substance use disorders. However, the concentration of these lipid transmitters might be ... -
Behavioral traits predicting cocaine-conditioned place reference in mice: role of anxiety adn the basolateral amygdala
Ladrón de Guevara-Miranda, David; Pavón-Morón, Francisco Javier; Serrano, Antonia; Rivera, Patricia; Estivill-Torrús, Guillermo; Suárez-Pérez, Juan; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2016-07-13)
Aims. The individual susceptibility to cocaine addiction, a factor of interest in the understanding and prevention of this disorder, may be predicted by certain behavioral traits. However, these are not usually taken into ... -
Beneficial Effects of Essential Oils from the Mediterranean Diet on Gut Microbiota and Their Metabolites in Ischemic Heart Disease and Type-2 Diabetes Mellitus
Sánchez-Quintero, María José; Delgado, Josué; Medina-Vera, Dina; Becerra-Muñoz, Víctor Manuel; Queipo-Ortuño, María Isabel; Estévez, Mario; Plaza-Andrades, Isaac; Rodríguez Capitán, Jorge; Sánchez, Pedro L.; Crespo-Leiro, María G.; Jiménez-Navarro, Manuel Francisco; Pavón-Morón, Francisco Javier[et al.] (IOAP-MPDI, 2022-11-03)
Ischemic heart disease (IHD) and type-2 diabetes mellitus (T2DM) remain major health problems worldwide and commonly coexist in individuals. Gut microbial metabolites, such as trimethylamine N-oxide (TMAO) and short-chain ... -
Búsqueda de nuevos biomarcadores de aortopatía en un modelo animal espontaneo de válvula aortica bicúspide
Martín-Chaves, Laura; Pozo-Vilumbrales, Bárbara; Soto-Navarrete, María Teresa; López-Unzu, Miguel A.; Rodríguez Capitán, Jorge; Pavón-Morón, Francisco Javier; Durán-Boyero, Ana Carmen; Fernández-Corujo, Borja[et al.] (Elsevier, 2021-10-29)
La válvula aortica bicúspide (VAB) es la malformación cardiaca congénita más frecuente en el hombre. Aproximadamente el 50% de los pacientes desarrollan dilatación en la aorta ascendente (DA), una condición denominada ... -
Chronic ethanol induces morpohological changes on hippocampal microglia, which are reverted by pharmacological blockade of faah with urb597
Fernández-Arjona, María del Mar; Rivera, Patricia; Silva-Peña, Daniel; Blanco, Eduardo; Vargas, Antonio; López-Ávalos, María Dolores; Mateos-Grondona, Jesús; Serrano, Antonia; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (2018-11-29)
Here, we evaluated the pharmacological effects of fatty-acid amide-hydrolase (FAAH) inhibitor URB597 (0.3 mg/kg), oleoylethanolamide (OEA, 10 mg/kg), arachidonoylethanolamide (AEA, 10 mg/kg), the CB1 receptor agonist ACEA ... -
Embryology of the abnormally high origin of a coronary artery (High Take-Off) in a mouse model.
Soto-Navarrete, María Teresa; Pozo-Vilumbrales, Bárbara; López-Unzu, Miguel A.; Pavón-Morón, Francisco Javier; Fernández-Corujo, Borja; Durán-Boyero, Ana Carmen[et al.] (2023)
High take-off (HTO) is a rare congenital coronary artery anomaly associated with sudden cardiac death. The coronary ostium is located in the ascending aorta above the sinotubular junction. The morphogenetic defect leading ... -
Endocrine and Metabolic impact of oral ingestion of a carob-pod derived natural syrup containing D-Pinitol: potential use as a novel sweetener in diabetes
Navarro, Juan Antonio; Decara, Juan; Dina, Medina; Tovar, Ruben; López-Gambero, Antonio J.; Pavón-Morón, Francisco Javier; Serrano, Antonia; De Ceglia, Marialuisa; Sanjuan, Carlos; Rodriguez-de-Fonseca, Fernando; Baixeras-Llano, Elena[et al.] (EMBO, 2022)
The use of added sugars or non-nutritive sweeteners in processed foods and soft drinks are being blamed for multiple complications associated with obesity and diabetes. High fructose content contributes to obesity and liver ... -
Enhancing adult hippocampal neurogenesis with lysophosphatidic acid: a proposal for erasing cocaine contextual memory
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2018-06-28)
Stimulating adult hippocampal neurogenesis (AHN) has been uncovered as a promising approach in the manipulation of retrograde memories. This work aims to study whether increasing AHN with lysophosphatidic acid (LPA, an ... -
Etiology of tricuspid regurgitation and mortality: a multicenter cohort study
Rodríguez Capitán, Jorge; Márquez‑Camas, Paloma; Carmona‑Carmona, Jesús; Arroyo Moñino, Diego Félix; Chaparro‑Muñoz, Marinela; Soler‑González, Matías; García del Río, Manuel; Egido de la Iglesia, Teodora; Segovia‑Reyes, Jorge; Murri, Mora; López Salguero, José Raúl; Couto‑Mallón, David; Romero‑Cuevas, Miguel; Pavón-Morón, Francisco Javier; Gutiérrez-Bedmar, Mario; Jiménez‑Navarro, Manuel[et al.] (Springer Nature, 2025)
Background Significant tricuspid regurgitation (TR) encompasses a wide range of etiologies, complicating a comprehensive understanding of disease progression and prognostic factors. This study aimed to assess mortality ... -
Evaluación del sistema del ácido lisofosfatídico como potencial biomarcador en los trastornos por uso de alcohol y cocaína.
(UMA Editorial, 2024)El consumo de sustancias psicoactivas es un problema de salud pública con repercusión a nivel mundial, especialmente el consumo de alcohol y cocaína, al ser dos de las sustancias por las que más se demanda asistencia en ... -
Experimental evidence of the genetic hypothesis on the etiology of bicuspid aortic valve aortopathy in the hamster model
Soto-Navarrete, María Teresa; Pozo-Vilumbrales, Bárbara; López-Unzu, Miguel A.; Rueda Martinez, Maria Del Carmen; Fernández-Domínguez, María Carmen; Durán-Boyero, Ana Carmen; Pavón-Morón, Francisco Javier; Rodríguez Capitán, Jorge; Fernández-Corujo, Borja[et al.] (Frontiers, 2022)
Bicuspid aortopathy occurs in approximately 50% of patients with bicuspid aortic valve (BAV), the most prevalent congenital cardiac malformation. Although different molecular players and etiological factors (genetic and ... -
LPA1/3 receptor antagonist KI16425 as a novel treatment for the neurobehavioural effects of the ethanol
Ladrón de Guevara-Miranda, David; Sánchez-Marín, Laura; Alén, Francisco; Moreno-Fernández, Román D.; García-Fernández, María Inmaculada; Gil Rodríguez, Sara; Gavito, Ana L.; García-Marchena, Nuria; Pedraza-Benítez, María del Carmen; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Serrano, Antonia; Castilla-Ortega, María Estela[et al.] (2017-07-24)
Aims. The lysophosphatidic acid (LPA) is an ubiquitous lysophospholipid that acts through G-protein coupled receptors (LPA1-6), and it is involved in the modulation of emotional and motivational behaviors. Recent literature ... -
Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Wiley, 2019)
Erasing memories of cocaine-stimuli associations might have important clinical implications for addiction therapy. Stimulating hippocampal plasticity by enhancing adult hippocampal neurogenesis (AHN) is a promising strategy ... -
Maladaptive stress-coping behavior in CX3CR1-deficient mice: Impact of adolescent stress and alcohol exposure on neuroimmune responses and inflammation
Medina-Vera, Dina; Martín-Chaves, Laura; Sánchez-Marín, Laura; Díaz-Ottaviano, María; Gavito, Ana L.; Popova, Olga; Sánchez-Quintero, María José; Rodríguez Capitán, Jorge; Rodriguez-de-Fonseca, Fernando; Jiménez-Navarro, Manuel Francisco; Serrano, Antonia; Pavón-Morón, Francisco Javier[et al.] (Elsevier, 2025-05-12)
The CX3CL1/CX3CR1 chemokine axis regulates synaptic pruning, plasticity, and stress-related behaviors, influencing resilience or vulnerability to psychiatric disorders. Adolescence, a critical period for neuroimmune ... -
More adult-born dentate gyrus neurons to weaken cocaine-related retrograde memories: an in vivo strategy employing exogenous lysophosphatidic acid
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2019-10-28)
The post-training enhancement of adult hippocampal neurogenesis (AHN) has been receiving growing interest as a potential method to manipulate retrograde memories. Recent hypothesis suggest that the addition of adult-born ... -
Multi-Omics Approach Reveals Prebiotic and Potential Antioxidant Effects of Essential Oils from the Mediterranean Diet on Cardiometabolic Disorder Using Humanized Gnotobiotic Mice.
Sánchez-Quintero, María José; Delgado, Josué; Martín-Chaves, Laura; Medina-Vera, Dina; Murri, Mora; Becerra-Muñoz, Víctor Manuel; Estévez, Mario; Crespo-Leiro, María G.; Paz López, Guillermo; González-Jiménez, Andrés; García-Ranea, Juan Antonio; Queipo-Ortuño, María Isabel; Plaza-Andrades, Isaac; Rodríguez Capitán, Jorge; Pavón-Morón, Francisco Javier; Jiménez-Navarro, Manuel Francisco[et al.] (MDPI, 2023-08-20)
Essential oils sourced from herbs commonly used in the Mediterranean diet have demonstrated advantageous attributes as nutraceuticals and prebiotics within a model of severe cardiometabolic disorder. The primary objective ... -
Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation
Sampedro-Piquero, Patricia; Ladrón de Guevara-Miranda, David; Pavón-Morón, Francisco Javier; Serrano, Antonia; Suárez-Pérez, Juan; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Elsevier, 2019)
Drug addiction is a chronic and relapsing disorder in which repeated drug exposure compromises brain neuroplasticity. Brain areas normally involved in learning and goal- directed behaviors become corrupted, which may lead ... -
Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex
(IOAP-MPDI, 2022-05-14)(1) Background: Co-occurrence of mental and substance use disorders (SUD) is prevalent, but complicates their clinical courses, and specific biomarkers are required. Amino acids are altered in primary mental disorders; ... -
Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease.
Flores-López, María; García-Marchena, Nuria; Pavón-Morón, Francisco Javier; Lara, Estrella; Porras Perales, Óscar; Araos, Pedro; Requena-Ocaña, Nerea; Torres-Galván, Sandra; Mañas-Padilla, María del Carmen; Rubio, Gabriel; Suárez-Pérez, Juan; Santín-Núñez, Luis Javier; Rodriguez-de-Fonseca, Fernando; Castilla-Ortega, María Estela; García-Fernández, María Inmaculada; Serrano, Antonia[et al.] (2021-09-13)
Lysophosphatidic acid (LPA) is an endogenous lysophospholipid and a bioactive lipid that is synthesized by the enzyme autotaxin (ATX). The ATX-LPA axis has been associated with cognitive dysfunction and inflammatory diseases, ... -
Plasma Concentrations of Neurofilament Light Chain Protein and Brain-Derived Neurotrophic Factor as Consistent Biomarkers of Cognitive Impairment in Alcohol Use Disorder
Requena-Ocaña, Nerea; Araos Gómez, Pedro Fernando; Serrano-Castro, Pedro Jesús; Flores-López, María; García-Marchena, Nuria; Oliver-Martos, Begoña; Ruiz-Ruiz, Juan Jesús; Gavito, Ana L.; Pavón-Morón, Francisco Javier; Serrano, Antonia; Mayoral Cleries, Fermín; Suárez-Pérez, Juan; Rodriguez-de-Fonseca, Fernando[et al.] (IOAP-MDPI, 2023-01-07)
For a long time, Substance Use Disorders (SUDs) were not considered a component in the etiology of dementia. The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders introduced substance-induced ...