Listar por autor "Ruano, Diego"
Mostrando ítems 1-4 de 4
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Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus.
Sánchez-Varo, Raquel María
; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Torres, Manuel; Baglietto-Vargas, David; Moreno-González, Inés; De Castro, Vanessa; Jiménez, Sebastián; Ruano, Diego; Vizuete, Marisa; Dávila-Cansino, José Carlos; García-Verdugo, José Manuel; Jiménez-Lara, Antonio Jesús; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Springer Nature, 2012)
Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus ... -
Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model.
Jiménez, Sebastián; Torres, Manuel; Vizuete, Marisa; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Carmona-Cuenca, Irene; Caballero, Cristina; Ruano, Diego; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Elsevier, 2011-05)
Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, BDNF, IGF-1, or insulin signaling are implicated in the pathogenesis of Alzheimer disease. We have ... -
Calretinin Interneurons are Early Targets of Extracellular Amyloid-beta Pathology in PS1/AbetaPP Alzheimer Mice Hippocampus.
Baglietto-Vargas, David; Moreno-González, Inés; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Torres, Manuel; Romero-Acebal, Manuel; Ruano, Diego; Vizuete, Marisa; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (IOS Press, 2010-07-08)
Specific neuronal networks are preferentially affected in the early stages of Alzheimer’s disease (AD). The distinct subpopulations of hippocampal inhibitory GABAergic system have been shown to display differential ... -
Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer’s Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic.
Jiménez, Sebastián; Baglietto-Vargas, David; Caballero, Cristina; Moreno-González, Inés; Torres, Manuel; Sánchez-Varo, Raquel María; Ruano, Diego; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Society for Neuroscience, 2008)
Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs neurodegeneration) has not yet been resolved. Here, we show the existence of an age-dependent phenotypic ...