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Listar por autor "Ruano, Diego"
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Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus.
Sánchez-Varo, Raquel María
; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Torres, Manuel; Baglietto-Vargas, David; Moreno-González, Inés; De Castro, Vanessa; Jiménez, Sebastián; Ruano, Diego; Vizuete, Marisa; Dávila-Cansino, José Carlos; García-Verdugo, José Manuel; Jiménez-Lara, Antonio Jesús; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Springer Nature, 2012)
Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus ... -
Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model.
Jiménez, Sebastián; Torres, Manuel; Vizuete, Marisa; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Carmona-Cuenca, Irene; Caballero, Cristina; Ruano, Diego; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Elsevier, 2011-05)
Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, BDNF, IGF-1, or insulin signaling are implicated in the pathogenesis of Alzheimer disease. We have ... -
Calretinin Interneurons are Early Targets of Extracellular Amyloid-beta Pathology in PS1/AbetaPP Alzheimer Mice Hippocampus.
Baglietto-Vargas, David; Moreno-González, Inés; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Torres, Manuel; Romero-Acebal, Manuel; Ruano, Diego; Vizuete, Marisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (IOS Press, 2010-07-08)
Specific neuronal networks are preferentially affected in the early stages of Alzheimer’s disease (AD). The distinct subpopulations of hippocampal inhibitory GABAergic system have been shown to display differential ... -
Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease.
Ramos, Blanca; Baglietto-Vargas, David; del Rio, Juan Carlos; Moreno-González, Inés; Santa-Maria, Consuelo; Jiménez, Sebastián; Caballero, Cristina; López-Téllez, Juan Félix; Khan, Zafar U.; Ruano, Diego; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Elsevier, 2006-11)
At advanced stages, Alzheimer's disease (AD) is characterized by an extensive neuronal loss. However, the early neurodegenerative deficiencies have not been yet identified. Here we report an extensive, selective and early ... -
Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice.
Moreno-González, Inés; Baglietto-Vargas, David; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Del Rio, Juan Carlos; Torres, Manuel; Romero-Acebal, Manuel; Ruano, Diego; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Sage, 2009-11-12)
Here we demonstrated that extracellular, not intracellular, Aβ and the associated cytotoxic glial neuroinflammatory response are major contributors of early neuronal loss in a PS1xAPP model. A significant loss of principal ... -
Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer’s Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic.
Jiménez, Sebastián; Baglietto-Vargas, David; Caballero, Cristina; Moreno-González, Inés; Torres, Manuel; Sánchez-Varo, Raquel María; Ruano, Diego; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Society for Neuroscience, 2008)
Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs neurodegeneration) has not yet been resolved. Here, we show the existence of an age-dependent phenotypic ... -
Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of Abeta peptides in the PS1xAPP transgenic mice.
Caballero, Cristina; Jiménez, Sebastián; Moreno-González, Inés; Baglietto-Vargas, David; Sánchez-Varo, Raquel María; Gavilán, M. Paz; Ramos, Blanca; Del Río, Juan Carlos; Vizuete, María Luisa; Gutiérrez-Pérez, Antonia; Ruano, Diego; Vitorica Ferrández, Javier[et al.] (Wiley, 2007-01-22)
La detección de las primeras modificaciones fenotípicas de los modelos de la enfermedad de Alzheimer (EA) es fundamental para comprender la progresión e identificar dianas farmacológicas de esta patología. Sin embargo, se ... -
Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons.
Gavilán, M. Paz; Revilla, Elisa; Pintado, Cristina; Castaño, Angélica; Vizuete, María Luisa; Moreno-González, Inés; Baglietto-Vargas, David; Sánchez-Varo, Raquel María; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia; Ruano, Diego[et al.] (Wiley, 2007-06-29)
Increased neuroinflammatory reaction is frequently observed during normal brain aging. However, a direct link between neuroinflammation and neurodegeneration during aging has not yet been clearly shown. Here, we have ...