Listar por autor "Sánchez-Pérez, José Andrés"
Mostrando ítems 1-8 de 8
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Decreased medial prefrontal cortex activity related to impaired novel object preference task performance following GALR2 and Y1R agonists intranasal infusion
Díaz-Sánchez, Estela; López-Salas, Alexander; Mirchandani-Duque, Marina; Álvarez-Contino, José Erik; Sánchez-Pérez, José Andrés; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; García-Casares, Natalia
; Narváez-Peláez, Manuel[et al.] (Elsevier, 2023)
Different brain regions’ interactions have been implicated in relevant neurological diseases, such as major depressive disorder (MDD), anxiety disorders, age-dependent cognitive decline, Alzheimer’s disease (AD) and addiction. ... -
Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder
Borroto-Escuela, Dasiel; Serrano-Castro, Pedro Jesús; Sánchez-Pérez, José Andrés; Barbancho-Fernández, Miguel Ángel; Fuxe, Kjell; Narváez-Peláez, Manuel[et al.] (Taylor & Francis, 2024-04-21)
Background: Major Depressive Disorder (MDD) is a prevalent and debilitating condition, necessitating novel therapeutic strategies due to the limited efficacy and adverse effects of current treatments. We explored how galanin ... -
Evidence for a synergistic effect of NPY1R agonist co-administered with Ketamine in rats: relevance to neurodegenerative and mood disorders.
Moreno Madrid, Isabel; Arrabal-Gómez, José Carlos; Díaz-Sánchez, Estela; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel Ángel; Sánchez-Pérez, José Andrés; Blanco-Reina, Encarnación; Beltrán-Casanueva, Rasiel; Hernández-García, Aracelis; Bayolo-Guanche, Juan Vicente; Romero-Imbroda, Jesús; Fuxe, Kjell; Borroto-Escuela, Dasiel O.; García-Casares, Natalia; Serrano-Castro, Pedro; Narváez-Peláez, Manuel[et al.] (2024)
Introduction/Objetives: Major depressive disorder is one of the most prevalent health problems worldwide and its current therapeutic approach still generates great dissatisfaction due to its limited efficacy, unwanted ... -
GALR2 and Y1R agonists intranasal infusion enhanced adultventral hippocampal neurogenesis and antidepressant‐likeeffects involving BDNF actions
Álvarez-Contino, José Erik; Díaz-Sánchez, Estela; Mirchandani-Duque, Marina; Sánchez-Pérez, José Andrés; Barbancho-Fernández, Miguel Ángel; López-Salas, Alexander; García-Casares, Natalia; Fuxe, Kjell; Borroto-Escuela, Dasiel O.; Narváez-Peláez, Manuel[et al.] (Wiley, 2023)
Dysregulation of adult hippocampal neurogenesis is linked to major depressive disorder(MDD), with more than 300 million people diagnosed and worsened by the COVID‐19pandemic. Accumulating evidence for neuropeptideY (NPY) ... -
Long- term enhancements in antidepressant efficacy and neurogenesis: Effects of intranasal co- administration of neuropeptide Y 1 receptor (NPY1R) and galanin receptor 2 (GALR2) agonists in the ventral hippocampus
Rasiel, Beltran-Casanueva; Aracelis, Hernández-García; Serrano-Castro, Pedro Jesús; Sánchez-Pérez, José Andrés; Barbancho-Fernández, Miguel Ángel; García-Casares, Natalia; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; Narváez-Peláez, Manuel[et al.] (WILEY, 2024-04-15)
This study evaluates the sustained antidepressant- like effects and neurogenic potential of a 3- day intranasal co- administration regimen of galanin receptor 2 (GALR2) agonist M1145 and neuropeptide ... -
Potentiation of antidepressant effects: NPY1R agonist and ketamine synergy enhances TrkB signaling and neurogenesis in the ventral hippocampus
(Taylor & Francis, 2024-04-18)Background: Major Depressive Disorder (MDD) poses a significant challenge to global health, with current treatments often limited by efficacy and onset delays. This study explores the synergistic antidepressant-like effects ... -
Synergistic Effects of Intranasally Administered GALR2 and Y1R Agonists on Cognitive and Mood-Related Behaviors in Adult Rats: Implications for Neurodegenerative and Mood Disorders
Moreno Madrid, Isabel; Arrabal-Gómez, José Carlos; Serrano-Castro, Pedro; Díaz-Sánchez, Estela; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel-Ángel; Sánchez-Pérez, José Andrés; Blanco-Reina, Encarnación; Fuxe, Kjell; Borroto-Escuela, Dasiel O.; García-Casares, Natalia; Narváez-Peláez, Manuel[et al.] (2024-06)
Abstract body: Background: The complexity of neurodegenerative and mood disorders necessitates innovative therapeutic strategies beyond current treatments. This study explores the combined therapeutic potential of Galanin ... -
Unveiling the Synergistic Interplay of Neuropeptides for Novel Therapeutic Approaches in Neurodegenerative and Depressive Disorders.
Díaz-Sánchez, Estela; López-Salas, Alexander; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel Ángel; Sánchez-Pérez, José Andrés; Blanco-Reina, Encarnación; Brito Rodríguez, Ismel; Serrano-Castro, Pedro Jesús; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; García-Casares, Natalia; Narváez-Peláez, Manuel[et al.] (2023)
The intricate relationship between hippocampal neurogenesis dysregulation and neurodegenerative diseases such as Alzheimer's, as well as depression, has sparked an urgent call for innovative therapeutic strategies. Our ...