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Downregulation of clusterin mediates sensitivity to protein kinase inhibitors in breast cancer cells.
Redondo-Bautista, Maximino; García Aranda, Marilina; Roldán Cardenete, María José; Callejón, Gonzalo; Serrano-Garballo, Alfonso
; Jimenez, Eugenio; Téllez-Santana, Teresa
[et al.] (Lipincott, 2015)
The efficacy of protein kinase inhibitors (PKIs) has been shown in clinical assays for cancer, but as isolated agents, they only have a modest effect. One of the most important characteristics of mitogen-activated PKIs is ...