Listar por autor "García-Cortés, Miren"
Mostrando ítems 1-20 de 25
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Análisis del perfil inmunitario en el diagnóstico diferencial entre la hepatotoxicidad idiosincrásica y la enfermedad hepática esteatósica no alcohólica
(UMA Editorial, 2024)La ausencia de métodos diagnósticos y biomarcadores junto a los límites que presentan las escalas de causalidad en el diagnóstico de hepatotoxicidad idiosincrásica (DILI) hacen que el diagnóstico se base en la exclusión ... -
Assessment of drug-induced liver injury in clinical practice.
Jiménez-Lucena, Isabel
; García-Cortés, Miren; Cueto-Galán, Raquel; López-Durán, José Luis; Andrade-Bellido, Raúl Jesús (Wiley, 2008)
Currently, pharmaceutical preparations are serious contributors to liver disease, with hepatotoxicity ranking as the most frequent cause for acute liver failure and postmarketing regulatory decisions. The diagnostic ... -
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana; Villanueva-Paz, Marina; Aukštikalnė, Lauryna; Stephens, Camilla; Robles-Díaz, María Mercedes; Pinazo-Bandera, José M.; García-Cortés, Miren; Conde, Isabel; Soriano, German; Bessone, Fernando; Hernandez, Nelia; Nunes, Vinicius; Parana, Raymundo; Lucena-González, María Isabel; Andrade, Raúl J.; Álvarez-Álvarez, Ismael; Niu, Hao[et al.] (Springer Nature, 2023-12-05)
Idiosyncratic drug-induced liver injury (DILI) associated with drug reactions with eosinophilia and systemic symptoms (DRESS) is poorly characterized among patients of Western countries. We aimed to comprehensively assess ... -
Clinical characteristics and outcome of drug-induced liver injury in the older patients: from the young-old to the oldest-old
Weersink, Rianne A.; Álvarez-Álvarez, Ismael; Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana; Robles-Díaz, María Mercedes; Ortega-Alonso, Aida; García-Cortés, Miren; Bonilla, Elvira; Niu, Hao; Soriano, German; Jiménez-Pérez, Miguel; Hallal, Hacibe; Blanco, Sonia; Kaplowitz, Neil; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Wiley, 2020-11-11)
Old patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver injury (DILI) cohorts. We sought for the distinctive characteristics of DILI in older patients across age groups. A total of ... -
Clinical presentation, causative drugs and outcome of patients with autoimmune features in two prospective DILI registries
García-Cortés, Miren; Ortega-Alonso, Aida; Matilla-Cabello, Gonzalo; Medina-Cáliz, Inmaculada; Castiella, Agustin; Conde, Isabel; Bonilla-Toyos, Elvira; Pinazo-Bandera, José M.; Hernandez, Nelia; Tagle, Martin; Nunes, Vinicius; Parana, Raymundo; Bessone, Fernando; Kaplowitz, Neil; Lucena-González, María Isabel; Álvarez-Álvarez, Ismael; Robles-Díaz, María Mercedes; Andrade-Bellido, Raúl Jesús[et al.] (Wiley, 2023)
Background & aims: Idiosyncratic drug-induced liver injury (DILI) with autoimmune features is a liver condition with laboratory and histological characteristics similar to those of idiopathic autoimmune hepatitis (AIH), ... -
Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry
Stephens, Camilla; Robles-Díaz, María Mercedes; Medina-Cáliz, Inmaculada; García-Cortés, Miren; Ortega-Alonso, Aida; Sanabria-Cabrera, Judith Adriana; González-Jiménez, Andrés; Álvarez-Álvarez, Ismael; Slim, Mahmoud; Jiménez-Pérez, Miguel; González-Grande, Rocío; Fernández, M. Carmen; Casado, Marta; Soriano, German; Roman, Eva; Hallal, Hacibe; Romero-Gomez, Manuel; Castiella, Agustin; Conde, Isabel; Prieto, Martin; Moreno-Planas, José María; Giraldez, Alvaro; Moreno-Sanfiel, J Miguel; Kaplowitz, Neil; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Elsevier, 2021-02-01)
Background & aims: Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis of 843 patients with DILI enrolled into ... -
Differential iNKT and T cells activation in non-alcoholic fatty liver disease and drug-induced liver injury.
Caballano-Infantes, Estefanía; García-García, Alberto; Lopez-Gomez, Carlos; Cueto-Sánchez, Alejandro; Robles-Díaz, María Mercedes; Ortega-Alonso, Aida; Martín-Reyes, Flores; Álvarez-Álvarez, Ismael; Arranz-Salas, Isabel María; Ruiz-Cabello, Francisco; Lucena-González, María Isabel; García-Fuentes, Eduardo; Andrade-Bellido, Raúl Jesús; García-Cortés, Miren[et al.] (MDPI, 2021-01-28)
Background: Non-alcoholic fatty liver disease (NAFLD) and idiosyncratic drug-induced liver injury (DILI) could share molecular mechanisms involving the immune system. We aimed to identify activation immunological biomarkers ... -
Drug-Induced Liver Injury in Latin America: 10-year experience of the Latin American DILI (LATINDILI) Network
Bessone, Fernando; Hernandez, Nelia; Medina-Caliz, Inmaculada; García-Cortés, Miren; Schinoni, María I.; Mendizabal, Manuel; Chiodi, Daniela; Nunes, Vinicius; Ridruejo, Ezequiel; Pazos, Ximena; Santos, Genario; Fassio, Eduardo; Parana, Raymundo; Reggiardo, Virginia; Tanno, Hugo; Sanchez, Adriana; Tanno, Federico; Montes, Pedro; Tagle, Martin; Arrese, Marco; Brahm, Javier; Girala, Marcos; Lizarzabal, M. Isabel; Carrera, Enrique; Zerega, Alina; Bianchi, Carla; Reyes, Laura; Arnedillo, Daina; Cordone, Antonella; Gualano, Gisela; Jaureguizahar, Fernanda; Rifrani, Gabriel; Robles‑Diaz, Mercedes; Ortega-Alonso, Aida; Pinazo-Bandera, José M.; Stephens, Camilla; Sanabria-Cabrera, Judith; Bonilla-Toyos, Elvira; Niu, Hao; Álvarez-Álvarez, Ismael; Lucena, M. Isabel; Andrade, Raúl J.[et al.] (Elsevier, 2024-07)
Background and aims: Latin America is a region of great interest for studying the clinical presentation of idiosyncratic drug-induced liver injury (DILI). A comprehensive analysis of patients enrolled into the LATINDILI ... -
Evaluación de causalidad en hepatotoxicidad
García-Cortés, Miren (Universidad de Málaga, Servicio de Publicaciones, 2006)
La hepatotoxicidad es un problema de salud pública infranotificado debido a la ausencia de marcadores diagnósticos específicos. En las últimas décadas se han venido desarrollando distintos métodos diagnósticos en ... -
Evaluation of diagnostic and prognostic candidate biomarkers in drug-induced liver injury vs. other forms of acute liver damage
Cueto-Sánchez, Alejandro; Niu, Hao; Álvarez-Álvarez, Ismael; López-Longarela, Bárbara; Del Campo-Herrera, Enrique; Ortega-Alonso, Aida; García-Cortés, Miren; Pinazo-Bandera, José M.; Sanabria-Cabrera, Judith Adriana; Díaz-Monchón, Juan José; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Stephens, Camilla; Robles-Díaz, María Mercedes[et al.] (Wiley, 2023)
Aims Detection and characterization of idiosyncratic drug-induced liver injury (DILI) currently rely on standard liver tests, which are suboptimal in terms of specificity, sensitivity and prognosis. Therefore, DILI diagnosis ... -
Hepatitis C virus point-of-care microelimination approach in a vulnerable population in the South of Spain.
Pinazo-Bandera, José M.; Aranda, Jesús; García-García, Alberto M.; Alcántara, Ramiro; Ortega-Alonso, Aida; Del Campo-Herrera, Enrique; Clavijo-Frutos, Encarnación; García-Escaño, M. Dolores; Ruiz Ruiz, Juan J.; Morales-Herrera, Mónica; Valle-López, Vanesa; Martín-Alarcón, Rosa; Viciana, Isabel; Jiménez, Juan Bautista; Fernández-García, Félix; Toro-Ortiz, Juan Pedro; Sánchez-Yáñez, Elena; Álvarez-Álvarez, Ismael; Andrade-Bellido, Raúl Jesús; Robles-Díaz, María Mercedes; García-Cortés, Miren[et al.] (Oxford Academic, 2024-01-22)
Background: Since the introduction of direct-acting antivirals, thousands of chronic hepatitis C patients have been successfully treated. However, vulnerable populations have a higher prevalence of hepatitis C virus (HCV) ... -
Herbal and dietary supplement-induced liver injuries in the spanish DILI registry
Medina-Cáliz, Inmaculada; García-Cortés, Miren; González-Jiménez, Andrés; Cabello-Porras, María Rosario; Robles-Díaz, María Mercedes; Sanabria-Cabrera, Judith Adriana; Sanjuan-Jimenez, Rocio; Ortega-Alonso, Aida; García-Muñoz, Beatriz; Moreno, Inmaculada; Jiménez-Pérez, Miguel; Fernández, M. Carmen; Ginés, Pere; Prieto, Martin; Conde, Isabel; Hallal, Hacibe; Soriano, German; Roman, Eva; Castiella, Agustin; Blanco-Reina, Encarnación; Montes, Maria R; Quiros-Cano, Marta; Martín-Reyes, Flores; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Elsevier, 2018-01)
There have been increasing reports of liver injury associated with use of herbal and dietary supplements.We collected and analyzed data on demographic and clinical features, along with biochemical parameters, of 32 patients ... -
Herbal and dietary supplements-induced liver injury in Latin America: Experience from the LATINDILI Network
Bessone, Fernando; García-Cortés, Miren; Medina-Cáliz, Inmaculada; Hernandez, Nelia; Parana, Raymundo; Mendizabal, Manuel; Schinoni, María I.; Ridruejo, Ezequiel; Nunes, Vinicius; Peralta, Mirta; Santos, Genario; Anders, Margarita; Chiodi, Daniela; Tagle, Martin; Montes, Pedro; Carrera, Enrique; Arrese, Marco; Lizarzabal, M. Isabel; Álvarez-Álvarez, Ismael; Caballano-Infantes, Estefanía; Niu, Hao; Pinazo, Jose; Cabello-Porras, María Rosario; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (Elsevier, 2022)
Background: Herbal and dietary supplements (HDS) consumption, a growing cause of hepatotoxicity, is a common practice among Latin-American populations. Objectives: To evaluate clinical, laboratory features and outcome ... -
Incidence and prevalence of acute hepatitis E virus infection in patients with suspected Drug-Induced Liver Injury in the Spanish DILI Registry
Sanabria-Cabrera, Judith Adriana; Sanjuan-Jimenez, Rocio; Clavijo-Frutos, Encarnación; Medina-Cáliz, Inmaculada; González-Jiménez, Andrés; García-Cortés, Miren; Ortega-Alonso, Aida; Jiménez-Pérez, Miguel; González-Grande, Rocío; Stephens, Camilla; Robles-Díaz, María Mercedes; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (2020)
Background and Aims: Drug-induced liver injury (DILI) presents with a wide phenotypic spectrum requiring an extensive differential diagnosis. Hepatitis E virus (HEV) is not systematically ruled out during acute hepatitis ... -
Intestinal permeability and immune-inflammatory markers in patients with idiosyncratic drug-induced liver injury, drug induced steatosis and metabolic dysfunction–associated steatotic liver disease (MASLD)
Di Zeo-Sánchez, Daniel Enrique; Díaz-Alberola, irene; Pinazo-Bandera, José M.; García-Cortés, Miren; Sanabria-Cabrera, Judith Adriana; Robles-Díaz, María Mercedes; Álvarez-Álvarez, Ismael; Lucena, M. Isabel; Andrade, Raúl J.; Villanueva-Paz, Marina; Stephens, Camilla[et al.] (Wiley, 2025)
Background and Purpose Adverse immuno-inflammatory responses possibly influenced by bacterial compounds reaching the liver as a consequence of altered intestinal permeability appear to be crucial in the pathogenesis of ... -
Lymphocyte Profile and Immune Checkpoint Expression in Drug-Induced Liver Injury: An Immunophenotyping Study
Cueto-Sánchez, Alejandro; Niu, Hao; Del Campo-Herrera, Enrique; Robles-Díaz, María Mercedes; Sanabria-Cabrera, Judith Adriana; Ortega-Alonso, Aida; García-Cortés, Miren; González-Grande, Rocío; Jiménez-Pérez, Miguel; Ruiz-Cabello, Francisco; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel[et al.] (Wiley, 2021-09-20)
The identification of specific HLA risk alleles in drug-induced liver injury (DILI) points toward an important role of the adaptive immune system in DILI development. In this study, we aimed to corroborate the role of an ... -
Membrane vesicles of toxigenic Clostridioides difficile affect the metabolism of liver hepG2 cells
Caballano-Infantes, Estefanía; Ho-Plágaro, Ailec; López-Gómez, Carlos; Martín-Reyes, Flores; Rodríguez-Pacheco, Francisca; Taminiau, Bernard; Daube, Georges; Garrido Sánchez, Lourdes; Alcaín-Martínez, Guillermo; Andrade-Bellido, Raúl Jesús; García-Cortés, Miren; Lucena-González, María Isabel; García Fuentes, Eduardo; Rodriguez-Diaz, Cristina[et al.] (MDPI, 2023-03-27)
Clostridioides difficile infection (CDI) appears to be associated with different liver diseases. C. difficile secretes membrane vesicles (MVs), which may be involved in the development of nonalcoholic fatty liver disease ... -
Methods for causality assessment of idiosyncratic drug-induced liver injury
The diagnosis of idiosyncratic drug-induced liver injury (DILI) is a challenging task due to the lack of specific features or definitive diagnostic tools. A minimum of clinical and pharmacological information is required, ... -
Microbiota diversity in nonalcoholic fatty liver disease and in drug-induced liver injury
Rodriguez-Diaz, Cristina; Taminiau, Bernard; García-García, Alberto; Cueto-Sánchez, Alejandro; Robles-Díaz, María Mercedes; Ortega-Alonso, Aida; Martín-Reyes, Flores; Daube, Georges; Sanabria-Cabrera, Judith Adriana; Jiménez-Pérez, Miguel; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; García Fuentes, Eduardo; García-Cortés, Miren[et al.] (Elsevier, 2022-08)
The gut microbiota could play a significant role in the progression of nonalcoholic fatty liver disease (NAFLD); however, its relevance in drug-induced liver injury (DILI) remains unexplored. Since the two hepatic disorders ... -
Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report
Andrade-Bellido, Raúl Jesús; Aithal, Guruprasad P.; De Boer, Ynto S.; Liberal, Rodrigo; Gerbes, Alexander L; Regev, Arie; Terziroli Beretta-Piccoli, Benedetta; Schramm, Christoph; Kleiner, David E.; De Martin, Eleonora; Kullak-Ublick, Gerd A; Stirnimann, Guido; Devarbhavi, Harshad; Vierling, John M.; Manns, Michael P.; Sebode, Marcial; Londoño, María Carlota; Avigan, Mark; Robles-Díaz, María Mercedes; García-Cortés, Miren; Atallah, Edmond; Heneghan, Michael; Chalasani, Naga; Trivedi, Palak J.; Hayashi, Paul H.; Taubert, Richard; Fontana, Robert J.; Weber, Sabine; Oo, Ye Htun; Zen, Yoh; Licata, Anna; Lucena-González, María Isabel; Mieli-Vergani, Giorgina; Vergani, Diego; Bjornsson, Einar S.[et al.] (Elsevier, 2023)
Drug-induced liver injury (DILI) can mimic almost all other liver disorders. A phenotype increasingly ascribed to drugs is autoimmune-like hepatitis (ALH). This article summarises the major topics discussed at a joint ...