- RIUMA Principal
- Listar por autor
Listar por autor "Jimenez-Guardeño, Jose Manuel"
Mostrando ítems 1-17 de 17
-
Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.
Burnap, Sean A.; Ortega-Prieto, Ana María; Jimenez-Guardeño, Jose Manuel; Ali, Hashim; Takov, Kaloyan; Fish, Matthew; Shankar-Hari, Manu; Giacca, Mauro; Malim, Michael H.; Mayr, Manuel[et al.] (Elsevier, 2023)High-density lipoprotein (HDL) levels are reduced in patients with coronavirus disease 2019 (COVID-19), and the extent of this reduction is associated with poor clinical outcomes. While lipoproteins are known to play a key ... -
Drug repurposing based on a quantum-inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2.
Jimenez-Guardeño, Jose Manuel; Ortega-Prieto, Ana María; Menéndez-Moreno, Borja; Maguire, Thomas; Richardson, Adam; Díaz-Hernández, Juan Ignacio; Díez- Pérez, Javier; Zuckerman, Mark; Cordero-Deline, Carlos; Malim, Michael H.; Martínez-Núñez, Rocío Teresa[et al.] (PLOS, 2022)The COVID-19 pandemic has accelerated the need to identify new antiviral therapeutics at pace, including through drug repurposing. We employed a Quadratic Unbounded Binary Optimization (QUBO) model, to search for compounds ... -
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia
Braga, Luca; Ali, Hashim; Secco, Ilaria; Chiavacci, Elena; Neves, Guilherme; Goldhill, Daniel; Penn, Rebecca; Jimenez-Guardeño, Jose Manuel; Ortega-Prieto, Ana María; Bussani, Rossana; Cannata, Antonio; Rizzari, Giorgia; Collesi, Chiara; Scheider, Edoardo; Arosio, Daniele; Ajay M, Shah; Barclay, Wendy S; Malim, Michael H.; Burrone, Juan; Giacca, Mauro[et al.] (Springer Nature, 2021)COVID-19 is a disease with unique characteristics that include lung thrombosis1, frequent diarrhoea2, abnormal activation of the inflammatory response3 and rapid deterioration of lung function consistent with alveolar ... -
Identification of the mechanisms causing reversion to virulence in an attenuated SARS-CoV for the design of a genetically stable vaccine
Jimenez-Guardeño, Jose Manuel; Regla-Nava, Jose Angel; Nieto-Torres, Jose Luis; DeDiego, Marta L.; Castaño-Rodriguez, Carlos; Fernandez-Delgado, Raul; Perlman, Stanley; Enjuanes, Luis[et al.] (Public Library of Science, 2015)A SARS-CoV lacking the full-length E gene (SARS-CoV-∆E) was attenuated and an effective vaccine. Here, we show that this mutant virus regained fitness after serial passages in cell culture or in vivo, resulting in the ... -
Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival
DeDiego, Marta L.; Nieto-Torres, Jose Luis; Regla-Nava, Jose Angel; Jimenez-Guardeño, Jose Manuel; Fernandez-Delgado, Raul; Fett, Craig; Castaño-Rodriguez, Carlos; Perlman, Stanley; Enjuanes, Luis[et al.] (ASM Journals, 2014)Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of a respiratory disease that has a 10% mortality rate. We previously showed that SARS-CoV lacking the E gene (SARS-CoV-ΔE) is attenuated ... -
Kinetics of Early Innate Immune Activation during HIV-1 Infection of Humanized Mice.
Skelton, Jessica Katy; Ortega-Prieto, Ana María; Kaye, Steve; Jimenez-Guardeño, Jose Manuel; Turner, Jane; Malim, Michael H.; Towers, Greg J.; Dorner, Marcus[et al.] (ASM Journals, 2019-05-15)Human immunodeficiency virus type 1 (HIV-1) infection is associated with aberrant immune activation; however, most model systems for HIV-1 have been used during established infection. Here, we utilize ultrasensitive HIV-1 ... -
Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans
Seow, Jeffrey; Graham, Carl; Merrick, Blair; Acors, Sam; Pickering, Suzanne; Steel, Kathryn JA; Hemmings, Oliver; O'Byrne, Aoife; Kouphou, Neophytos; Galao, Rui Pedro; Betancor, Gilberto; Wilson, Harry D; Signell, Adrian W; Winstone, Helena; Kerridge, Claire; Huettner, Isabella; Jimenez-Guardeño, Jose Manuel; Lista, Maria Jose; Temperton, Nigel; Snell, Luke B; Bisnauthsing, Karen; Moore, Amelia; Green, Adrian; Martinez, Lauren; Stokes, Brielle; Honey, Johanna; Izquierdo-Barras, Alba; Arbane, Gill; Patel, Amita; Ik Tan, Mark Kia; O'Connell, Lorcan; O'Hara, Geraldine; MacMahon, Eithne; Douthwaite, Sam; Nebbia, Gaia; Batra, Rahul; Martinez-Nunez, Rocio; Shankar-Hari, Manu; Edgeworth, Jonathan D; Neil, Stuart JD; Malim, Michael H.; Doores, Katie J[et al.] (2020)Antibody responses to SARS-CoV-2 can be detected in most infected individuals 10-15 d after the onset of COVID-19 symptoms. However, due to the recent emergence of SARS-CoV-2 in the human population, it is not known how ... -
Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction
Dicks, Matthew DJ; Betancor, Gilberto; Jimenez-Guardeño, Jose Manuel; Pessel-Vivares, Lucie; Apolonia, Luis; Goujon, Caroline; Malim, Michael H.[et al.] (Public Library of Science, 2018)Human myxovirus resistance 2 (MX2/MXB) is an interferon-induced post-entry inhibitor of human immunodeficiency virus type-1 (HIV-1) infection. While the precise mechanism of viral inhibition remains unclear, MX2 is localized ... -
MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation
Betancor, Gilberto; Jimenez-Guardeño, Jose Manuel; Lynham, Steven; Antrobus, Robin; Khan, Hataf; Sobala, Andrew; Dicks, Matthew DJ; Malim, Michael H.[et al.] (Springer Nature, 2021)The antiviral cytokine interferon activates expression of interferon-stimulated genes to establish an antiviral state. Myxovirus resistance 2 (MX2, also known as MxB) is an interferon-stimulated gene that inhibits the ... -
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant
Graham, Carl; Seow, Jeffrey; Huettner, Isabella; Khan, Hataf; Kouphou, Neophytos; Acors, Sam; Winstone, Helena; Pickering, Suzanne; Galao, Rui Pedro; Dupont, Liane; Lista, Maria Jose; Jimenez-Guardeño, Jose Manuel; Laing, Adam G; Wu, Yin; Joseph, Magdalene; Muir, Luke; van Gils, Marit J; Ng, Weng M; Duyvesteyn, Helen ME; Zhao, Yuguang; Bowden, Thomas A; Shankar-Hari, Manu; Rosa, Annachiara; Cherepanov, Peter; McCoy, Laura E; Hayday, Adrian C; Neil, Stuart JD; Malim, Michael H.; Doores, Katie J[et al.] (Elsevier, 2021)Interaction of the SARS-CoV-2 Spike receptor binding domain (RBD) with the receptor ACE2 on host cells is essential for viral entry. RBD is the dominant target for neutralizing antibodies, and several neutralizing epitopes ... -
Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern.
Dupont, Liane; Snell, Luke B; Graham, Carl; Seow, Jeffrey; Merrick, Blair; Lechmere, Thomas; Maguire, Thomas; Hallett, Sadie R.; Pickering, Suzanne; Charalampous, Themoula; Alcolea-Medina, Adela; Huettner, Isabella; Jimenez-Guardeño, Jose Manuel; Acors, Sam; Almeida, Nathalia; Cox, Daniel; Dickenson, Ruth; Galao, Rui Pedro; Kouphou, Neophytos; Lista, Maria Jose; Ortega-Prieto, Ana María; Wilson, Harry D; Winstone, Helena; Fairhead, Casssandra; Su, Jia Zhe; Nebbia, Gaia; Batra, Rahul; Neil, Stuart JD; Shankar-Hari, Manu; Edgeworth, Jonathan D; Malim, Michael H.; Doores, Katie J[et al.] (Nature Research, 2021)COVID-19 vaccine design and vaccination rollout need to take into account a detailed understanding of antibody durability and cross-neutralizing potential against SARS-CoV-2 and emerging variants of concern (VOCs). Analyses ... -
Role of severe acute respiratory syndrome Coronavirus Viroporins E, 3a, and 8a in replication and pathogenesis
Castaño-Rodriguez, Carlos; Honrubia, José M.; Gutiérrez-Álvarez, Javier; DeDiego, Marta L.; Nieto-Torres, Jose Luis; Jimenez-Guardeño, Jose Manuel; Regla-Nava, Jose Angel; Fernandez-Delgado, Raul; Verdiá-Báguena, Carmina; Queralt-Martín, María; Kochan, Grazyna; Perlman, Stanley; Aguilella, Vicente M; Sola, Isabel; Enjuanes, Luis[et al.] (American Society for Microbiology, 2018)Viroporins are viral proteins with ion channel (IC) activity that play an important role in several processes, including virus replication and pathogenesis. While many coronaviruses (CoVs) encode two viroporins, severe ... -
Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome
Nieto-Torres, Jose Luis; Verdiá-Báguena, Carmina; Jimenez-Guardeño, Jose Manuel; Regla-Nava, Jose Angel; Castaño-Rodriguez, Carlos; Fernandez-Delgado, Raul; Torres, Jaume; Aguilella, Vicente M; Enjuanes, Luis[et al.] (Elsevier, 2015)Severe acute respiratory syndrome coronavirus (SARS-CoV) envelope (E) protein is a viroporin involved in virulence. E protein ion channel (IC) activity is specifically correlated with enhanced pulmonary damage, edema ... -
Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis
Nieto-Torres, Jose Luis; DeDiego, Marta L.; Verdiá-Báguena, Carmina; Jimenez-Guardeño, Jose Manuel; Regla-Nava, Jose Angel; Fernandez-Delgado, Raul; Castaño-Rodriguez, Carlos; Alcaraz, Antonio; Torres, Jaume; Aguilella, Vicente M; Enjuanes, Luis[et al.] (2014)Deletion of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) envelope (E) gene attenuates the virus. E gene encodes a small multifunctional protein that possesses ion channel (IC) activity, an important function ... -
Severe acute respiratory syndrome coronaviruses with mutations in the E protein are attenuated and promising vaccine candidates
Regla-Nava, Jose Angel; Nieto-Torres, Jose Luis; Jimenez-Guardeño, Jose Manuel; Fernandez-Delgado, Raul; Fett, Craig; Castaño-Rodriguez, Carlos; Perlman, Stanley; Enjuanes, Luis; DeDiego, Marta L.[et al.] (ASM Journals, 2015)Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease with a mortality rate of 10%. A mouse-adapted SARS-CoV (SARS-CoV-MA15) lacking the envelope (E) protein (rSARS-CoV-MA15-ΔE) is attenuated ... -
Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein
Nieto-Torres, Jose Luis; López-De-Diego, Marta; Álvarez-Coruña, Enrique; Jimenez-Guardeño, Jose Manuel; Regla-Nava, Jose Angel; Llorente-Gómez, Mercedes; Kremer, Leonor; Shuo, Shen; Enjuanes, Luis[et al.] (Elsevier, 2011)Severe acute respiratory syndrome (SARS) coronavirus (CoV) envelope (E) protein is a transmembrane protein. Several subcellular locations and topological conformations of E protein have been proposed. To identify the correct ... -
The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis
Jimenez-Guardeño, Jose Manuel; Nieto-Torres, Jose Luis; DeDiego, Marta L.; Regla-Nava, Jose Angel; Fernandez-Delgado, Raul; Castaño-Rodriguez, Carlos; Enjuanes, Luis[et al.] (2014)A recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) lacking the envelope (E) protein is attenuated in vivo. Here we report that E protein PDZ-binding motif (PBM), a domain involved in protein-protein ...