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Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination
Fricker, Florence R; Antunes-Martins, Ana; Galino, Jorge; Paramsothy, Remi; La Russa, Federica; Perkins, James; Goldberg, Rebecca; Brelstaff, Jack; Zhu, Ning; McMahon, Stephen B; Orengo, Christine; Garratt, Alistair N; Birchmeier, Carmen; Bennett, David LH; Perkins[et al.] (Oxford University Press, 2013-07)Neuregulin 1 acts as an axonal signal that regulates multiple aspects of Schwann cell development including the survival and migration of Schwann cell precursors, the ensheathment of axons and subsequent elaboration of the ... -
Development of bioinformatics tools and studies in biomedical association networks for the analysis of human genetic diseases
Rojano Rivera, María Elena (UMA Editorial, 2019-11)El presente trabajo de tesis doctoral se centra en el análisis en red y desarrollo de herramientas bioinformáticas para la determinación de las causas que dan lugar a las enfermedades con base genética. Mediante el análisis ... -
Network-Based Methods for Approaching Human Pathologies from a Phenotypic Point of View
Ranea, Juan A. G.; Richard Perkins, James; Chagoyen, Mónica; Díaz-Santiago, Elena Dolores; Pazos, Florencio (IOAP-MPDI, 2022-06-17)Network and systemic approaches to studying human pathologies are helping us to gain insight into the molecular mechanisms of and potential therapeutic interventions for human diseases, especially for complex diseases where ...