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Listar por autor "Fernández-Arjona, María del Mar"
Mostrando ítems 1-17 de 17
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Anxiety and mild microglial activation in the amygdala two weeks after NA-induced neuroinflammation
León-Rodríguez, Ana; Fernández-Arjona, María del Mar; Pedraza-Benítez, María del Carmen; Mateos-Grondona, Jesús; López-Ávalos, María Dolores; León-Rodríguez, Ana[et al.] (Wiley Periodicals, LLC, 2021-07)A single injection of neuraminidase (NA) within the cerebral ventricles (ICV) triggers an acute neuroinflammation. Neurological complications or behavioral alterations have been associated to neuroinflammation. While some ... -
Chronic ethanol induces morpohological changes on hippocampal microglia, which are reverted by pharmacological blockade of faah with urb597
Fernández-Arjona, María del Mar; Rivera, Patricia; Silva-Peña, Daniel; Blanco, Eduardo; Vargas, Antonio; López-Ávalos, María Dolores; Mateos-Grondona, Jesús; Serrano, Antonia; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (2018-11-29)Here, we evaluated the pharmacological effects of fatty-acid amide-hydrolase (FAAH) inhibitor URB597 (0.3 mg/kg), oleoylethanolamide (OEA, 10 mg/kg), arachidonoylethanolamide (AEA, 10 mg/kg), the CB1 receptor agonist ACEA ... -
Correlation between IL1β expression level and morphological parameters proves the usefulness of morphology measures to predict the degree of activation of microglial cells
Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2017-10-04)It is well known that microglial cells undergo an important change in morphology upon activation, so that form and function are intimately related. Upon activation, microglia cell body enlarges, its ramifications shortens ... -
Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer’s disease
López-Gambero, Antonio J.; Pacheco-Sánchez, Beatriz; Rosell-del-Valle, Cristina; Medina-Vera, Dina; Navarro, Juan Antonio; Fernández-Arjona, María del Mar; De Ceglia, Marialuisa; Sanjuán-Solís, Jesús Carlos; Simon, Vincent; Cota, Daniela; Rivera, Patricia; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (Elsevier, 2022-06)Increasing evidence shows that hypothalamic dysfunction, insulin resistance, and weight loss precede and progress along with the cognitive decline in sporadic Alzheimer’s Disease (AD) with sex differences. This study aimed ... -
Enhanced stress response in rats that suffered acute neuroinflammation induced by neuraminidase three months before
León-Rodríguez, Ana; Mateos-Grondona, Jesús; Fernández-Arjona, María del Mar; Pedraza-Benítez, María del Carmen; López-Ávalos, María Dolores (2022)Microglial cells are protagonists in neuroinflammatory processes and their activation is a notorious feature of such events. In acute inflammation, microglial cells return to their basal surveillant state in few days. ... -
Long-term priming of hypothalamic microglia is associated with energy balance disturbances under diet-induced obesity
Fernández-Arjona, María del Mar; León-Rodríguez, Ana; Mateos-Grondona, Jesús; López-Ávalos, María Dolores (Wiley, 2022-05-22)Exposure of microglia to an inflammatory environment may lead to their priming and exacerbated response to future inflammatory stimuli. Here we aimed to explore hypothalamic microglia priming and its consequences on energy ... -
Morphological traits of surveillant/activated microglia during an experimentally induced acute neuroinflammatory process
Fernández-Arjona, María del Mar; López-Ávalos, María Dolores; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro (2016-07-12)Several studies show that morphological changes of microglia over the course of inflammation are tightly coupled to function. However the progressive transformation into activated microglia is poorly characterized. AIMS: ... -
Neuraminidase-activated microglia compromise the viability of ependymocytes
Fernández-Arjona, María del Mar; López-Ávalos, María Dolores; Mateos-Grondona, Jesús; Carrillo-Pinzón, Cristóbal; Fernández-Llebrez, Pedro (2017-10-04)Neuraminidase (NA) is a sialidase present in the envelope/wall of some virus/bacteria responsible for brain infections, such as flu, mumps or meningitis. The intracerebroventricular injection of NA in the rat brain provokes ... -
Neuraminidase-induced neuroinflammation causes anxiety and microgliosis in the amygdala
León-Rodríguez, Ana; Fernández-Arjona, María del Mar; Pedraza-Benítez, María del Carmen; Mateos-Grondona, Jesús; López-Ávalos, María Dolores (2021)An intracerebroventricular (ICV) injection of neuraminidase (NA) within the lateral ventricles originates an acute event of neuroinflammation, which is solved to a great extent after two weeks. Recently, neurological ... -
Neuraminidase-induced neuroinflammation is largely dependent on microglial TLR4 receptor
Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2019-10-01)The sialidase neuraminidase (NA) cleaves terminal sialic acid from glycoproteins and glycolipids. Among its various locations, it is present in the envelope/membrane of some bacteria/viruses (e.g. influenza virus), where ... -
Notas corológicas del macrofitobentos de Andalucía (España). X
Fernández-Arjona, María del Mar; Bañares-España, Elena; Flores-Moya, Antonio (Universidad de Málaga. Servicio de Publicaciones, 2011) -
Papel de la microglía en la neuroinflamación generada mediante neuraminidasa
Fernández-Arjona, María del Mar (UMA Editorial, 2017-12-19)Está ampliamente aceptado que en algunas ocasiones la neuroinflamación es un proceso previo al desarrollo de enfermedades neurodegenerativas y que la microglía juega un papel clave en el desarrollo de la misma. En particular, ... -
Plasma endocannabinoid alterations as a link in the comorbidity of Alzheimer's disease and type 2 diabetes mellitus.
López-Gambero, Antonio Jesús; Reyes, José Antonio; Fernández-Arjona, María del Mar; Rubio-Lamia, Leticia Olga; Rivera, Patricia; Serrano-Castro, Pedro Jesús; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (2023)Over the last several years, studies have suggested a role of endocannabinoids such as 2-AG and 2-OG in the impairment of β-cell function and insulin secretion, as well as in the control of lipid and glucose metabolism in ... -
Plasma endocannabinoids as potential biomarkers of type 2 diabetes mellitus in elderly patients with mild cognitive impairment
López-Gambero, Antonio J.; Reyes, José Antonio; Fernández-Arjona, María del Mar; Rubio-Lamia, Leticia Olga; Rivera, Patricia; Serrano-Castro, Pedro Jesús; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (Sociedad Española de Investigación sobre Cannabinoides (SEIC), 2022)Background: Besides their role in the nervous system and the development of cognitive impairment in elderly patients, compelling evidence suggests that endocannabinoids (ECBs) are related to motivational responses in obesity ... -
Primed microglia after acute neuroinflammation may drive an enhanced stress response.
López-Ávalos, María Dolores; Pedraza-Benítez, María del Carmen; Mateos-Grondona, Jesús; Fernández-Arjona, María del Mar; León-Rodríguez, Ana (2023)Microglial cells become activated during acute neuroinflammation and usually they return to their basal surveillant state in a few days. However, sometimes microglia evolve towards a primed state characterized by an ... -
Sudden cessation of fluoxetine before alcohol drinking reinstatement alters microglial morphology and TLR4/inflammatory neuroadaptation in the rat brain
Aranda, Jesús; Fernández-Arjona, María del Mar; Alén, Francisco; Rivera, Patricia; Rubio, Leticia; Smith-Fernández, Inés María[et al.] (SPRINGER, 2021-07-08)Preclinical studies on the efects of abrupt cessation of selective serotonin reuptake inhibitors (SSRIs), a medication often prescribed in alcohol use disorder (AUD) patients with depression, results in alcohol consumption ... -
The ependymal detach due to neuraminidase provokes hydrocephalus
Fernández-Arjona, María del Mar; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; López-Ávalos, María Dolores; Mateos-Grondona, Jesús; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; Fernández-Llebrez, Pedro[et al.] (2015-05-27)Background: In many cases there seems to exist a tight relationship between the integrity of the ependymal barrier and the onset of hydrocephalus (see 1). We wanted to investigate this by means of a repetitive model that ...