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Anticlusterin treatment of breast cancer cells increases the sensitivities of chemotherapy and tamoxifen and counteracts the inhibitory action of dexamethasone on chemotherapy-induced cytotoxicity
Redondo-Bautista, Maximino; Téllez-Santana, Teresa; Roldán Cardenete, María José; Serrano-Garballo, Alfonso; García Aranda, Marilina; Gleave, Martin E; Hortas Nieto, María Luisa; Morell Ocaña, Miguel[et al.] (BMC Springer Nature, 2007-12-13)Introduction: Overexpression of the apoptosis-related protein clusterin is associated with breast cancer development and tumor progression. We describe the use of clusterin-specific antisense oligonucleotides and antibodies ... -
Calcium Homeostasis in the Development of Resistant Breast Tumors.
Martin-García, Desirée; Téllez-Santana, Teresa; Redondo-Bautista, Maximino; García Aranda, Marilina (MDPI, 2023-05-23)Cancer is one of the main health problems worldwide. Only in 2020, this disease caused more than 19 million new cases and almost 10 million deaths, with breast cancer being the most diagnosed worldwide. Today, despite ... -
Efecto de la inhibición de la clusterina sobre la sensibilidad a los inhibidores de proteínas quinasas en células tumorales de mama
García Aranda, Marilina (UMA Editorial, 2015)En la actualidad, el cáncer supone la segunda causa de muerte en el mundo, siendo el cáncer de mama la neoplasia maligna sólida más frecuentemente diagnosticada en las mujeres occidentales y la que presenta una mayor ... -
Neurokinin-1 Receptor (NK-1R) Antagonists as a New Strategy to Overcome Cancer Resistance
García Aranda, Marilina; Téllez-Santana, Teresa; McKenna, Lauraine; Redondo-Bautista, Maximino (IOAP-MPDI, 2022-04-30)Nowadays, the identification of new therapeutic targets that allow for the development of treatments, which as monotherapy, or in combination with other existing treatments can contribute to improve response rates, prognosis ...