Listar por autor "Boraldi, Federica"
Mostrando ítems 1-8 de 8
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Antioxidant and neuroprotective actions of IGF-II against glucocorticoid-induced toxicity in dopaminergic neurons.
Claros-Gil, Silvia
; Valverde Moreno, Nadia; Zamorano-González, Pablo; Romero-Zerbo, Silvana Yanina; Lara Fernández, Estrella; Boraldi, Federica; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (2023)
The neurodegenerative Parkinson’s disease (PD) affects 1–3% of the population aged over 65. A wide range of pathways and mechanisms are involved in its pathogenesis, such as oxidative stress, mitochondrial dysfunction, ... -
Fingolimod phosphate protection against mitochondrial damage in neuronal cells
Martín-Montañez, Elisa; Gil Cebrián, Antonio Jesús; Valverde, Nadia; Lara, Estrella; De Luque, Vanessa; Boraldi, Federica; Urbano, María; García-Fernández, María Inmaculada; Pavía-Molina, José[et al.] (Elsevier, 2019-04-17)
Background: Major role of oxidative stress in the pathogenesis of neurodegenerative diseases have been suggested, being mitochondria one of the main sources of ROS. Aim: In the present work, we have studied the antioxidant ... -
IGF-II as a neuroprotective and neuroplastic factor in an oxidative damage model induced by glucocorticoids
Lara Fernández, Estrella; Valverde, Nadia; De Luque, Vanessa; Boraldi, Federica; Santín-Núñez, Luis Javier; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (2018-10-11)
IGF-II is a pleiotropic hormone widely distributed in the CNS, which triggers its functions by binding to IGF-IR, InsulinR and IGFII / M6P (IGF-IIR) receptors. Recently, it has been proposed that the effects of IGF-II, ... -
IGF-II treatment prevents the oxidative damage derived by MPP+/MPTP administration in a cellular and animal model of Parkinson’s disease.
Zamorano-González, Pablo; Valverde, Nadia; Claros-Gil, Silvia; López-González, Manuel Víctor; Romero-Zerbo, Silvana Yanina; Lara, Estrella; Boraldi, Federica; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (2023)
El factor de crecimiento de la insulina-II (IGF-II) ha mostrado efectos antioxidantes y neuroprotectores en algunos trastornos neurodegenerativos, como es la Enfermedad de Parkinson (EP). Analizamos el efecto de IGF-II ... -
Neuroprotective effects of insulin-like growth factor II in a mouse model of Parkinson's disease
Ladrón de Guevara-Miranda, David; Martín-Montañez, Elisa; Valverde, Nadia; Lara, Estrella; Romero-Zerbo, Silvana Yanina; Millón-Peñuela, Carmelo; Boraldi, Federica; Ávila-Gámiz, Fabiola; Pérez-Cano, Ana María; Garrido-Gil, Pablo; Labandeira-García, José Luis; Santín-Núñez, Luis Javier; Pavía-Molina, José; García-Fernández, María Inmaculada[et al.] (2022-07-20)
Progressive degeneration of the nigrostriatal dopaminergic pathway is a core, currently irreversible pathological hallmark of Parkinson’s disease (PD) that leads to a variety of motor and non-motor symptoms. Here, we aimed ... -
New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson's disease
Romero-Zerbo, Silvana Yanina; Valverde, Nadia; Claros-Gil, Silvia; Zamorano-González, Pablo; Boraldi, Federica; Lofaro, Francesco-Demetrio; Lara, Estrella; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (Elsevier, 2024-02-08)
Introduction One of the hallmarks of Parkinsońs Disease (PD) is oxidative distress, leading to mitochondrial dysfunction and neurodegeneration. Insulin-like growth factor II (IGF-II) has been proven to have antioxidant ... -
Papel del receptor S1P sobre el estrés oxidativo mitocondrial en cultivo neuronal
Valverde, Nadia; Lara, Estrella; Gil Cebrián, Antonio Jesús; De Luque, Vanessa; Boraldi, Federica; Pavía-Molina, José; Fernández, Oscar; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (2019-06-25)
Introducción: Fingolimod, fármaco inmunomodulador, presenta propiedades neuroprotectoras que podrían promover la recuperación de la función cognitiva en enfermedades neurodegenerativas. El estrés oxidativo parece tener un ... -
Relationship Between Mitochondrial Structure and Bioenergetics in Pseudoxanthoma elasticum Dermal Fibroblasts.
Lofaro, Francesco-Demetrio; Boraldi, Federica; García-Fernández, María Inmaculada; Lara, Estrella; Valdivielso-Felices, Pedro; Quaglino, Daniela[et al.] (Frontiers Media, 2020-12-17)
PXE is a genetic disease considered as a paradigm of ectopic mineralization disorders, being characterized by multisystem clinical manifestations due to progressive calcification of skin, eyes, and the cardiovascular system, ...