Listar por autor "Brichette-Mieg, Isabel"
Mostrando ítems 1-4 de 4
-
Infectivity decline of an RNA plant virus by increased mutagenesis in vivo
Díaz-Martínez, Luis; Brichette Mieg, Isabel; Grande-Pérez, Ana
(2014-08-01)
According to the lethal defection model, during lethal mutagenesis viral genomes with a low degree of mutation and low specific infectivity exert an interfering activity that leads to virus loss. Lethal mutagenesis of plant ... -
Infectivity decline of an RNA plant virus by increased mutagenesis supports the lethal defection model in vivo
Brichette Mieg, Isabel; Díaz-Martínez, Luis; Grande-Pérez, Ana (2013-07-30)
Lethal mutagenesis is a new antiviral therapy based on increasing the mutation rate by using mutagenic base and nucleoside analogues whose molecular mechanisms are not fully understood. Most of the research has been conducted ... -
Recombinant soluble type I interferon receptor exerts antiviral activity by inducing proteins related to autophagy
Aliaga-Gaspar, Pablo; Brichette-Mieg, Isabel; Fernández-Arjona, María del Mar; Rodríguez-Bada, José Luis; Lopez-Moreno, Yolanda; Serrano-Castro, Pedro Jesús; Fernández Fernández, Oscar; Ciano-Petersen, Nicolas Lundahl; Oliver-Martos, Begoña[et al.] (Elsevier, 2024)
The soluble type I IFN receptor (sIFNAR2) is produced by alternative splicing and is present in body fluids. Although it can modulate IFN-ß activity, its biological role remains unknown. Methods: An in-silico study was ... -
Soluble Receptor Isoform of IFN-Beta (sIFNAR2) in Multiple Sclerosis Patients and Their Association With the Clinical Response to IFN-Beta Treatment
Aliaga-Gaspar, Pablo; Hurtado-Guerrero, Isaac; Ciano-Petersen, Nicolas Lundahl; Urbaneja, Patricia; Brichette Mieg, Isabel; Virginia Reyes, Virginia; Rodríguez-Bada, José Luis; Alvarez-Lafuente, Roberto; Arroyo, Rafael; Quintana, Ester; Ramió-Torrentà, Lluis; Alonso, Ana; Leyva-Fernández, Laura; Fernández-Fernández, Óscar; Oliver-Martos, Begoña[et al.] (2021-12)
Protein and mRNA levels of sIFNAR2 increased after IFN-b treatment. According to the clinical response, only non-responders increased sIFNAR2 significantly at both protein and mRNA levels. sIFNAR2 gene expression correlated ...