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Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen
Rodríguez-Agudo, Rubén; Goikoetxea-Usandizaga, Naroa; Serrano-Maciá, Marina; Fernández-Tussy, Pablo; Fernández-Ramos, David; Lachiondo-Ortega, Sofía; González-Recio, Irene; Gil-Pitarch, Clàudia; Mercado-Gómez, María; Bizkarguenaga, Maider; Lopitz-Otsoa, Fernando; Petrov, Petar; Bravo, Miren; Martijn Van Liempd, Sebastiaan; Falcón-Pérez, Juan Manuel; Zabala-Letona, Amaia; Carracedo, Arkaitz; Vicente Castell, Jose; Jover, Ramiro; Martínez-Cruz, Luis Alfonso; Cardoso Delgado, Teresa; Cubero, Francisco Javier; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Mabe, Jon; Simón, Jorge; Martínez-Chantar, María Luz[et al.] (IOAP-MPDI, 2022-04-30)Drug-induced liver injury (DILI) development is commonly associated with acetaminophen (APAP) overdose, where glutathione scavenging leads to mitochondrial dysfunction and hepatocyte death. DILI is a severe disorder without ...