Listar por autor "González Vidal, Alejandro"
Mostrando ítems 1-20 de 23
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Acquisition resistance to bleomycin deregulates HSP77 and HSP60 proteins in response to stress
Burgos-Molina, Antonio Manuel
; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
The HSP77 and HSP60 protein overexpression is implicated in bleomycin resistance. The resistant adquisition to antineoplastic drugs deregulate proteins involved in response to stress factors. -
Analysis of Immunotherapy in hepatocellular carcinoma
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
One reason immunotherapy is important for Hepatocellular carcinoma, it’s because there are many immune cells in that organ. Because HCC is very aggressive, immunotherapy must be applied correctly. There are a lot of ... -
Analysis of Immunotherapy in Lung cancer
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
There are many ways of immunotherapy for lung cancer, and that includes the use of drugs, molecular treatment, and even the combination with radiotherapy. But also, it’s important to investigate in the future the adverse ... -
Analysis of Immunotherapy in ovarian cancer
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
There are many Immunotherapy methods in ovarian cancer. Even the immune cells themselves can be part of the immunotherapy. But also at molecular level, the immunotherapy can be applied, like maintaining damage in DNA or ... -
Analysis of Immunotherapy in Triple negative breast cancer
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
TNBC cancer is complicated, most is about PD-L1 mechanism. Too many kinds of immunotherapy have been developed to treat TNCB. Nowadays, is complicated a fast and 100% accurate treatment for TNBC, because of cancer complications ... -
Beneficial interactions between the microbiota and the host increase immunity for a better response to treatment of cancer patients
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Mercado-Sáenz, Silvia; Alamilla Presuel, Juan Carlos; Ruiz-Gómez, Miguel José (2022)
Numerous beneficial interactions between microbiota and host contribute to produce nutrients, metabolites, immunoglobulins and an increase in lymphocytes. The correct colonization of the intestine by microbiota induces a ... -
Cellular microenvironment can be modulated by factors influenced by microbiota to improve cancer treatment
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Mercado-Sáenz, Silvia; Alamilla Presuel, Juan Carlos; Ruiz-Gómez, Miguel José (2022)
Numerous environmental factors affect the ecosystem of the microbiota, so its composition and diversity can be modified by changes produced in these factors. These alterations can facilitate the appearance of pathological ... -
Clinical metagenomic analysis and Cancer
Burgos-Molina, Antonio Manuel; Mercado-Sáenz, Silvia; Morales Moreno, Francisco; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
After seven years of periodic controls by the SEIMC (Spanish Society of Infectious Diseases and Clinical Microbiology), it can be affirmed that the analysis is capable of detecting microorganisms in any type of sample ... -
Construction techniques and architectural design to reduce the level of radon inside buildings and therefore the risk of cancer
Burgos-Molina, Antonio Manuel; Ruiz-González, Óscar M.; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (2022)
The incorporation of anti-radon membranes and forced ventilation and depressurization systems in buildings contributes to reduce the concentration of radon inside rooms. In this way, the exposure to radiation in its ... -
Exposure of cancer cells to heat shock protein inhibitors induces decreased tumour survival
Burgos-Molina, Antonio Manuel; Peinado-Ruiz, Isabel C.; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (2022)
All tumour studied show an increase in resistance to treatment and an increase in cell survival. This response is related to an increase in the heat shock protein HSP90, since it participates in the assembly of telomerase, ... -
Heat shock proteins overexpressed in tumour cells and their relationship with ageing and cellular resistance to treatment
Burgos-Molina, Antonio Manuel; Peinado-Ruiz, Isabel C.; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (2022)
The increase in the concentration of HSP in tumour cells produces an increase in the capacity for replication, migration, and drug resistance. HSP and HSF1 factor are involved in the etiology of breast cancer. The ... -
Increased resistance to drugs and longer life cycle by the administration of exogenous agents to normal human cells
Burgos-Molina, Antonio Manuel; Peinado-Ruiz, Isabel C.; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (2022)
Exogenous HSP70 provides protection against oxidative stress and that it could be a good therapeutic strategy to treat age-related macular degeneration. On the other hand, externally inoculating a heat shock protein to ... -
Metabolism is altered in the process of drug resistance acquisition
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
Cells need energy to survive, therefore, they increase the different pathways available to obtain it. This suggests that the cell, due to the cytotoxicity of bleomycin, increases the routes to obtain energy. For this reason, ... -
Methods to study the intestinal microbiota to address the disease in a more precise and personalized way
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Mercado-Sáenz, Silvia; Alamilla Presuel, Juan Carlos; Ruiz-Gómez, Miguel José (2022)
FISH, clone collection, DGGE, PCR and metagenomics techniques contribute to the study of the human microbiota in a precise and effective way, constituting very useful diagnostic tools in precision medicine to address patient ... -
Microbiota and body axes as a new therapeutic approach in precision medicine
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; Ruiz-Gómez, Miguel José (2022)
There is a marked relationship between the composition and diversity of the microbiota and various diseases distant from the intestine. This relationship occurs through different body axes between the intestine and the ... -
Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity.
González Vidal, Alejandro; Mercado-Sáenz, Silvia; Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; Alcaraz, Miguel; Sendra-Portero, Francisco; Ruiz-Gómez, Miguel José[et al.] (MDPI, 2023-08-30)
The repair of the damage produced to the genome and proteome by the action of ionizing radiation, oxidizing agents, and during aging is important to maintain cellular homeostasis. Many of the metabolic pathways influence ... -
Presence of radon pollution in buildings and risk of cancer
Burgos-Molina, Antonio Manuel; Ruiz González, Óscar M.; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (2022)
Radon gas present in the ground penetrates into homes through different routes, accumulating especially in rooms close to the ground. The dose received from radioactivity due to inhalation of radon inside houses poses a ... -
Proteins involved in carbon metabolism induce bleomycin resistance
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; González Vidal, Alejandro; Ruiz González, Óscar M.; Ruiz-Gómez, Miguel José[et al.] (Aseica, 2022)
S. cerevisiae acquires bleomycin resistance after a long-term exposure to this drug which causes overexpression of TPIS protein. It could be involved in the resistance process. For this reason, it could be good candidates ... -
Response of normal human cells to stress causing agents and their relationship with ageing and cellular resistance
Burgos-Molina, Antonio Manuel; Peinado-Ruiz, Isabel C.; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (, 2022)
By applying low doses of a stressor, normal cells increase the number of HSP leading to increased survival. This phenomenon is considered a cellular adaptive response. The results show that treatment with low doses of a ... -
Role of SODC protein in antineoplastic drug resistance
Alamilla Presuel, Juan Carlos; González Vidal, Alejandro; Ruiz González, Óscar M.; Burgos-Molina, Antonio Manuel; Ruiz-Gómez, Miguel José (Aseica, 2022)
Cells need homeostasis to survive, therefore, they use the different pathways available to obtain it. The SODC protein overexpression, which is implicated in this process, suggests that could be implicated in the process ...