Listar por autor "Valverde, Nadia"
Mostrando ítems 1-9 de 9
-
Cocaine detrimentally affects mitochondrial functionality and cell viability in dopaminergic neurons.
Zamorano-González, Pablo; Bandini, Luca; Valverde, Nadia; Claros-Gil, Silvia
; Romero-Zerbo, Silvana Yanina; Lara, Estrella; Santín-Núñez, Luis Javier; Martín-Montañez, Elisa; Gago-Calderón, Belén; García-Fernández, María Inmaculada[et al.] (2024)
An elevated consumption of cocaine (benzoylmethylecgonine), which causes anesthetic and stimulant effects on the central nervous system, may be associated with several neurodegenerative conditions affecting dopaminergic ... -
Fingolimod phosphate protection against mitochondrial damage in neuronal cells
Martín-Montañez, Elisa; Gil Cebrián, Antonio Jesús; Valverde, Nadia; Lara, Estrella; De Luque, Vanessa; Boraldi, Federica; Urbano, María; García-Fernández, María Inmaculada; Pavía-Molina, José[et al.] (Elsevier, 2019-04-17)
Background: Major role of oxidative stress in the pathogenesis of neurodegenerative diseases have been suggested, being mitochondria one of the main sources of ROS. Aim: In the present work, we have studied the antioxidant ... -
IGF-II as a neuroprotective and neuroplastic factor in an oxidative damage model induced by glucocorticoids
Lara Fernández, Estrella; Valverde, Nadia; De Luque, Vanessa; Boraldi, Federica; Santín-Núñez, Luis Javier; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (2018-10-11)
IGF-II is a pleiotropic hormone widely distributed in the CNS, which triggers its functions by binding to IGF-IR, InsulinR and IGFII / M6P (IGF-IIR) receptors. Recently, it has been proposed that the effects of IGF-II, ... -
IGF-II treatment prevents the oxidative damage derived by MPP+/MPTP administration in a cellular and animal model of Parkinson’s disease.
Zamorano-González, Pablo; Valverde, Nadia; Claros-Gil, Silvia; López-González, Manuel Víctor; Romero-Zerbo, Silvana Yanina; Lara, Estrella; Boraldi, Federica; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (2023)
El factor de crecimiento de la insulina-II (IGF-II) ha mostrado efectos antioxidantes y neuroprotectores en algunos trastornos neurodegenerativos, como es la Enfermedad de Parkinson (EP). Analizamos el efecto de IGF-II ... -
Insulin-like growth factor II neuroprotective effects against mitochondrial-oxidative and neuronal damage induced by CORT and MPP+ in dopaminergic neurons
Claros-Gil, Silvia; Cabrera García, Pablo; Valverde, Nadia; Romero-Zerbo, Silvana Yanina; Lara, Estrella; López-González, Manuel Víctor; Shumilov, Kirill; Rivera-Ramírez, Alicia; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (2022-07-12)
Aims: Parkinson’s disease (PD) affects 1–3% of the population aged over 65. Stress seems to contribute to PD neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors are oxidative ... -
Neuroprotective effects of insulin-like growth factor II in a mouse model of Parkinson's disease
Ladrón de Guevara-Miranda, David; Martín-Montañez, Elisa; Valverde, Nadia; Lara, Estrella; Romero-Zerbo, Silvana Yanina; Millón-Peñuela, Carmelo; Boraldi, Federica; Ávila-Gámiz, Fabiola; Pérez-Cano, Ana María; Garrido-Gil, Pablo; Labandeira-García, José Luis; Santín-Núñez, Luis Javier; Pavía-Molina, José; García-Fernández, María Inmaculada[et al.] (2022-07-20)
Progressive degeneration of the nigrostriatal dopaminergic pathway is a core, currently irreversible pathological hallmark of Parkinson’s disease (PD) that leads to a variety of motor and non-motor symptoms. Here, we aimed ... -
New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson's disease
Romero-Zerbo, Silvana Yanina; Valverde, Nadia; Claros-Gil, Silvia; Zamorano-González, Pablo; Boraldi, Federica; Lofaro, Francesco-Demetrio; Lara, Estrella; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (Elsevier, 2024-02-08)
Introduction One of the hallmarks of Parkinsońs Disease (PD) is oxidative distress, leading to mitochondrial dysfunction and neurodegeneration. Insulin-like growth factor II (IGF-II) has been proven to have antioxidant ... -
Papel del receptor S1P sobre el estrés oxidativo mitocondrial en cultivo neuronal
Valverde, Nadia; Lara, Estrella; Gil Cebrián, Antonio Jesús; De Luque, Vanessa; Boraldi, Federica; Pavía-Molina, José; Fernández, Oscar; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (2019-06-25)
Introducción: Fingolimod, fármaco inmunomodulador, presenta propiedades neuroprotectoras que podrían promover la recuperación de la función cognitiva en enfermedades neurodegenerativas. El estrés oxidativo parece tener un ... -
Role of Insulin-Growth Factor II on mitochondrial recovery in a cellular model of Parkinson's Disease
Valverde, Nadia; Romero-Zerbo, Silvana Yanina; Lara, Estrella; Claros-Gil, Silvia; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (Journal of Physiology and Biochemistry, 2022-09)
Insulin-growth factor II (IGF-II) has shown antioxidant and neuroprotective effects in some neurodegenerative disorders. ROS causes damage to cellular macromolecules affecting several cellular processes and resulting in ...