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Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana; Villanueva-Paz, Marina; Aukštikalnė, Lauryna; Stephens, Camilla; Robles-Díaz, María Mercedes; Pinazo-Bandera, José M.; García-Cortés, Miren; Conde, Isabel; Soriano, German; Bessone, Fernando; Hernandez, Nelia; Nunes, Vinicius; Parana, Raymundo; Lucena-González, María Isabel; Andrade, Raúl J.; Alvarez-Alvarez, Ismael; Niu, Hao[et al.] (Springer Nature, 2023-12-05)Idiosyncratic drug-induced liver injury (DILI) associated with drug reactions with eosinophilia and systemic symptoms (DRESS) is poorly characterized among patients of Western countries. We aimed to comprehensively assess ... -
Control compounds for preclinical drug-induced liver injury assessment: Consensus-driven systematic review by the ProEuroDILI network
Segovia-Zafra, Antonio; Villanueva-Paz, Marina; Serras, Ana Sofía; Matilla-Cabello, Gonzalo; Bodoque-García, Ana; Di Zeo-Sánchez, Daniel Enrique; Niu, Hao; Álvarez-Álvarez, Ismael; Sanz-Villanueva, Laura; Godec, Sergej; Milisav, Irina; Bagnaninchi, Pierre; Andrade, Raúl J.; Lucena, M. Isabel; Fernandez-Checa, J.C.; Cubero, Francisco Javier; Paiva Miranda, Joana; Nelson, Leonard J.[et al.] (Elsevier, 2024)Background & Aims Idiosyncratic drug-induced liver injury (DILI) is a complex and unpredictable event caused by drugs, and herbal or dietary supplements. Early identification of human hepatotoxicity at preclinical stages ... -
Critical Review of Gaps in the Diagnosis and Management of Drug-Induced Liver Injury Associated with Severe Cutaneous Adverse Reactions
Villanueva-Paz, Marina; Niu, Hao; Segovia-Zafra, Antonio; Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Alvarez-Alvarez, Ismael; Sanabria-Cabrera, Judith Adriana[et al.] (MDPI, 2021-11-15)Drug-induced liver injury (DILI) encompasses the unexpected damage that drugs can cause to the liver. DILI may develop in the context of an immunoallergic syndrome with cutaneous manifes- tations, which are sometimes severe ... -
Mitochondrial Stress Links Environmental Triggers with Pro-Inflammatory Signaling in Crohn's Disease
Martín-Reyes, Flores; Bernal, Manuel; Rodríguez-Díaz, Cristina; Rodríguez-de los Reyes, Damaris; Ho-Plagaro, Ailec; Rodríguez-Pacheco, Francisca; Camacho- Martel, Laura; Camargo-Camero, Raquel; Rodríguez-González, Francisco J; Alcaín-Martínez, Guillermo; Martin‐Masot, Rafael; Navas-López, Víctor M; Villanueva-Paz, Marina; Lucena, María Isabel; García-Fuentes, Eduardo; López-Gómez, Carlos[et al.] (MDPI, 2023)Inflammatory Bowel Diseases (IBD) are a group of chronic, inflammatory disorders of the gut. The incidence and activity of IBD are determined by both genetic and environmental factors. Among these factors, polymorphisms ... -
Oxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice
Villanueva-Paz, Marina; Morán, Laura; López-Alcántara, Nuria; Freixo, Cristiana; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Cubero, Francisco Javier[et al.] (MDPI, 2021-03-05)Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an uncommon drug adverse reaction that can develop to conditions spanning from asymptomatic liver laboratoryabnormalitiestoacuteliverfa ... -
Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction
Segovia-Zafra, Antonio; Di Zeo-Sánchez, Daniel Enrique; López-Gómez, Carlos; Pérez-Valdés, Zeus; García-Fuentes, Eduardo; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Villanueva-Paz, Marina[et al.] (Elsevier, 2021-12)Idiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that pre- scription and non-prescription drugs, herbal and dietary supplements can cause to the liver. iDILI remains a major public health ... -
Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet
Lucena-González, María Isabel; Villanueva-Paz, Marina; Alvarez-Alvarez, Ismael; Aithal, Guruprasad P.; Bjornsson, Einar S.; Cakan-Akdogan, G.; Cubero, Francisco Javier; Esteves, Freddy; Falcón-Pérez, Juan Manuel; Fromenty, B.; Garcia-Ruiz, C.; Grove, J.I.; Konu, O.; Kranendonk, M.; Kullak-Ublick, Gerd A; Miranda, J.P.; Remesal-Doblado, A.; Sancho-Bru, P.; Nelson, L.; Andrade-Bellido, Raúl Jesús; Fernandez-Checa, J.C.[et al.] (Elsevier, 2023-12-28)In the current article the aims for a constructive way forward in Drug-Induced Liver Injury (DILI) are to highlight the most important priorities in research and clinical science, therefore supporting a more informed, ...