Listar por autor "Aledo-Ramos, Juan Carlos"
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Los átomos de azufre próximos a los anillos de residuos aromáticos son menos susceptibles de ser oxidados
El grupo tioéter de las metioninas confiere, a las proteínas portadoras, una alta vulnerabilidad a la oxidación. Sin embargo, no todos los residuos metionil de una proteína son igualmente susceptibles de oxidación. Aunque ... -
Glutaminase activity is confined to the mantle of the islets of Langerhans.
Montero, Fernando; Baglietto-Vargas, David; Moreno-González, Inés; López-Téllez, Juan Félix; Cuesta Muñoz, Antonio L.; Gutiérrez-Pérez, Antonia
; Aledo-Ramos, Juan Carlos[et al.] (Elsevier, 2007)
Glutamatergic signalling plays an important role in the coordination of hormone secretion from the endocrine pancreas. Thus, glutamate production must be a process exquisitely regulated to ensure a proper transmitter ... -
Pine has two glutamine synthetase paralogs, GS1b.1 and GS1b.2, exhibiting distinct biochemical properties
Valderrama-Martín, José Miguel; Ortigosa Peña, Francisco; Aledo-Ramos, Juan Carlos; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel; Cañas-Pendón, Rafael Antonio[et al.] (Wiley, 2023)
The enzyme glutamine synthetase (EC 6.3.1.2) is mainly responsible for the incorporation of inorganic nitrogen into organic molecules in plants. In the present work, a pine (Pinus pinaster) GS1 (PpGS1b.2) gene was identified, ... -
Pine has two glutamine synthetase paralogs, GS1b.1 and GS1b.2, exhibiting distinct biochemical properties.
Valderrama-Martín, José Miguel; Ortigosa Peña, Francisco; Aledo-Ramos, Juan Carlos; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel; Cañas-Pendón, Rafael Antonio[et al.] (Wiley, 2023)
The enzyme glutamine synthetase (EC 6.3.1.2) is mainly responsible for the incorporation of inorganic nitrogen into organic molecules in plants. In the present work, a pine (Pinus pinaster) GS1 (PpGS1b.2) gene was identified, ... -
Prediction of Protein Oxidation Sites
Veredas-Navarro, Francisco Javier; Cantón, Francisco R.; Aledo-Ramos, Juan Carlos (Springer International Publishing AG, 2017-05-18)
Although reactive oxygen species are best known as damag- ing agents linked to aerobic metabolism, it is now clear that they can also function as messengers in cellular signalling processes. Methionine, one of the two ... -
Proteome-Wide Structural Computations Provide Insights into Empirical Amino Acid Substitution Matrices
Aledo, Pablo; Aledo-Ramos, Juan Carlos (IOAP-MDPI, 2023-01-02)
The relative contribution of mutation and selection to the amino acid substitution rates observed in empirical matrices is unclear. Herein, we present a neutral continuous fitness-stability model, inspired by the Arrhenius ... -
Segregation of two glutaminase isoforms in islets of Langerhans.
Baglietto-Vargas, David; López-Téllez, Juan Félix; Moreno-González, Inés; Gutiérrez-Pérez, Antonia; Aledo-Ramos, Juan Carlos (Portland Press, 2004-01-31)
Despite the importance of glutamatergic signalling in the co-ordination of hormone secretion, the identity of the enzyme for the production of glutamate in β-cells is still unresolved. We have found that the endocrine ...