Listar por autor "Soto, Claudio"
Mostrando ítems 1-13 de 13
-
18F-THK5351 PET imaging, neuropathology and clinical progression in a tau mouse model
(Alzheimer disease & Parkinson disease Conference 2021, 2021)Aims: Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. The neuropathology of AD is characterized by the extracellular deposition of ... -
Aggregate-Depleted Brain Fails to Induce Ab Deposition in a Mouse Model of Alzheimer’s Disease.
(PLOS, 2014-02-12)Recent studies in animal models of Alzheimer’s disease (AD) show that amyloid-beta (Ab) misfolding can be transmissible; however, the mechanisms by which this process occurs have not been fully explored. The goal of this ... -
Amyloid-b seeding and propagation processes in a hAb-KI model of Alzheimer's disease
Trujillo-Estrada, Laura Isabel
; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Cheung, Alwin; Pham Tran, Janine; Núñez-Díaz, Cristina; Forner, Stefania; Martini, Alessandra C.; Da Cunha, Celia; Shahnawaz, Mohammad; Soto, Claudio; Moreno-González, Inés; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2020-12-17)
Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo.
(BMC, 2013-11-18)Background: One of the main features of Alzheimer’s disease (AD) is the presence of Aβ deposits, which accumulate in the brain years before the onset of symptoms. We and others have demonstrated that cerebral Aβ-amyloidosis ... -
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.
(Springer Nature, 2021-04-23)The majority of Alzheimer’s disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant ... -
Impaired Peripheral Lymphatic Function and Cerebrospinal Fluid Outflow in a Mouse Model of Alzheimer's Disease
(Sage Journals, 2019)Cerebrospinal fluid (CSF) outflow from the brain occurs through absorption into the arachnoid villi and, more predominantly, through meningeal and olfactory lymphatics that ultimately drain into the peripheral lymphatics. ... -
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism
(Rockefeller University PRess, 2017)Although a large proportion of patients with type 2 diabetes (T2D) accumulate misfolded aggregates composed of the islet amyloid polypeptide (IAPP), its role in the disease is unknown. Here, we show that pancreatic IAPP ... -
Longitudinal assessment of tau pet imaging and its correlation with neuropathology and clinical signs progression
(Cold Spring Harbor Laboratory, 2020-12-02)Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. As the world’s population increases, so does the prevalence of age-related dementias. The ... -
Peripheral delivery of neural precursor cells ameliorates parkinson’s disease-associated pathology
(MDPI, 2019)Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by loss of motor control due to a wide loss of dopaminergic neurons along the nigro-striatal pathway. Some of the mechanisms that contribute ... -
Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease
Moreno-Gonzalez, Ines; Estrada, Lisbell D; Sánchez-Mejías, Elisabeth; Soto, Claudio (Macmillan Publishers Limited, 2013-02)
Several epidemiological studies have shown that cigarette smoking might alter the incidence of Alzheimer’s disease. However, inconsistent results have been reported regarding the risk of Alzheimer’s disease among smokers. ... -
The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo
(Springer Nature, 2017)Prion diseases are fatal neurodegenerative disorders affecting several mammalian species, characterized by the accumulation of the misfolded form of the prion protein, which is followed by the induction of endoplasmic ... -
Traumatic brain injury induces tau aggregation and spreading.
(Mary Ann Liebert Inc., 2020)The misfolding and aggregation of tau protein into neurofibrillary tangles is the main underlying hallmark of tauopathies. Most tauopathies have a sporadic origin and can be associated with multiple risk factors. Traumatic ... -
Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo.
(Springer Nature, 2018)Transmissible spongiform encephalopathies (TSEs) are fatal neurological disorders caused by prions, which are composed of a misfolded protein (PrP Sc) that self-propagates in the brain of infected individuals by converting ...