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Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.
Martín-Rufián, Mercedes; Nascimento-Gomes, Renata; Higuero, Ana; Crisma, Amanda R.; Campos-Sandoval, José A.; Gómez-García, María C.; Cardona, Carolina; Cheng, Tzuling; Lobo, Carolina; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Szeliga, Monika; Albrecht, Jan; Curi, Rui; Márquez-Gómez, Javier; Colquhoun, Alison; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (Springer Nature, 2014)Mitochondrial glutaminase (GA) plays an essential role in cancer cell metabolism, contributing to biosynthesis, bioenergetics, and redox balance. Humans contain several GA isozymes encoded by the GLS and GLS2 genes, but ...