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Listar por autor "Castilla-Ruiz, Laura"
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The immunomodulator dimethyl itaconate inhibits several key steps of angiogenesis in cultured endothelial cells
Vidal-Valenzuela, Isabel; Fernández-Florido, Elena; Marrero-Capitán, Ana Dácil; Castilla-Ruiz, Laura; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (MDPI, 2022)The dimethyl derivative of the immunomodulator itaconate has been previously shown to have anti-inflammatory, anti-oxidative, and immunomodulatory effects. In the present work, we evaluate the potential of dimethyl itaconate ... -
The Sponge-Derived Brominated Compound Aeroplysinin-1 Impairs the Endothelial Inflammatory Response through Inhibition of the NF-κB Pathway
Vidal-Valenzuela, Isabel; Castilla-Ruiz, Laura; Marrero-Capitán, Ana Dácil; Bravo-Ruiz, Inés; Bernal-Muñoz, Manuel; Manrique-Poyato, María Inmaculada; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Poveda, Beatriz Amparo; Vidal-Valenzuela[et al.] (MDPI, 2022)Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge Aplysina aerophoba that exhibits pleiotropic bioactive effects, impairing cell growth in cancer cells, inhibiting angiogenesis in vitro and ...