Listar por autor "Serrano-Castro, Pedro"
Mostrando ítems 1-20 de 21
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Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis.
Rosell-del-Valle, Cristina; Pedraza-Benítez, María del Carmen
; Manuel, Iván; Moreno-Rodríguez, Marta; Rodríguez-Puertas, Rafael; Castilla-Ortega, María Estela; Caramés-Tejedor, José María; Gómez-Conde, Ana Isabel; Zambrana-Infantes, Emma; Ortega-Pinazo, Jesús; Serrano-Castro, Pedro Jesús; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021-06-06)
Several studies have demonstrated that lysophosphatidic acid (LPA) acts through its LPA receptors in multiple biological and behavioral processes, including adult hippocampal neurogenesis, hippocampal-dependent memory, and ... -
Cross-reactivity of antibodies against interferon beta in multiple sclerosis patients and interference of the JAK-STAT signaling pathway
Hurtado-Guerrero, Isaac; Pinto-Medel, Maria Jesus; Urbaneja, Patricia; Rodríguez-Bada, José Luis; Ortega-Pinazo, Jesús; Serrano-Castro, Pedro Jesús; Fernández-Fernández, Óscar; Leyva-Fernández, Laura; Oliver-Martos, Begoña[et al.] (Nature, 2017)
Interferon beta (IFNβ) therapy has immunogenic properties and induces the development of neutralizing antibodies (NAbs). From the extensive literature focused in the development of NAbs in multiple sclerosis (MS) patients, ... -
Effect of Cenobamate on Cognition in Patients with Drug‑Resistant Epilepsy with Focal Onset Seizures: An Exploratory Study
Serrano-Castro, Pedro Jesús; Ramírez-García, Teresa; Cabezudo-García, Pablo; García-Martín, Guillermina; De-La-Parra, Juan (Springer Nature, 2024-01-24)
Most second and third generation antiseizure medications (ASMs) are associated with cognitive adverse events, which are a major concern for patients. However, the profile of cognitive adverse events differs between ASMs. ... -
Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder
Borroto-Escuela, Dasiel; Serrano-Castro, Pedro Jesús; Sánchez-Pérez, José Andrés; Barbancho-Fernández, Miguel Ángel; Fuxe, Kjell; Narváez-Peláez, Manuel[et al.] (Taylor & Francis, 2024-04-21)
Background: Major Depressive Disorder (MDD) is a prevalent and debilitating condition, necessitating novel therapeutic strategies due to the limited efficacy and adverse effects of current treatments. We explored how galanin ... -
Enhancement of neurogenesis and cognition through intranasal co-delivery of galanin receptor 2 (GALR2) and neuropeptide Y receptor 1 (NPY1R) agonists: a potential pharmacological strategy for cognitive dysfunctions.
Sánchez-Varo, Raquel María; López-Salas, Alexander; Rasiel, Beltran-Casanueva; Díaz-Sánchez, Estela; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel Ángel; Serrano-Castro, Pedro Jesús; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; García-Casares, Natalia; Narváez-Peláez, Manuel[et al.] (Springer Nature, 2024-03-28)
Background: Spatial memory deficits and reduced neuronal survival contribute to cognitive decline seen in the aging process. Current treatments are limited, emphasizing the need for innovative therapeutic strategies. This ... -
Enhancing Cognitive Functions and Neuronal Growth through NPY1R Agonist and Ketamine Co-Administration: Evidence for NPY1R-TrkB Heteroreceptor Complexes in Rats
Arrabal-Gómez, José Carlos; Rasiel, Beltran-Casanueva; Hernández-García, Aracelis; Bayolo-Guanche, Juan Vicente; Barbancho-Fernández, Miguel Ángel; Serrano-Castro, Pedro Jesús; Narváez, Manuel[et al.] (2024-04-12)
This study investigates the combined effects of the neuropeptide Y Y1 receptor (NPY1R) agonist [Leu31-Pro34]NPY at a dose of 132 g and Ketamine at 10 mg/Kg on cognitive functions and neuronal proliferation, against a ... -
Epilepsia asociada a autoinmunidad: prevalencia y características en pacientes con epilepsia farmacorresistente del lóbulo temporal de etiología desconocida e inicio no reciente.
(UMA Editorial, 2023)En esta investigación, se determinó la prevalencia de la epilepsia asociada a autoinmunidad (EAA) en pacientes adultos con epilepsia farmacorresistente del lóbulo temporal de etiología desconocida (EFLTED) de inicio no ... -
Evidence for a synergistic effect of NPY1R agonist co-administered with Ketamine in rats: relevance to neurodegenerative and mood disorders.
Moreno Madrid, Isabel; Arrabal-Gómez, José Carlos; Díaz-Sánchez, Estela; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel Ángel; Sánchez-Pérez, José Andrés; Blanco-Reina, Encarnación; Beltrán-Casanueva, Rasiel; Hernández-García, Aracelis; Bayolo-Guanche, Juan Vicente; Romero-Imbroda, Jesús; Fuxe, Kjell; Borroto-Escuela, Dasiel O.; García-Casares, Natalia; Serrano-Castro, Pedro; Narváez-Peláez, Manuel[et al.] (2024)
Introduction/Objetives: Major depressive disorder is one of the most prevalent health problems worldwide and its current therapeutic approach still generates great dissatisfaction due to its limited efficacy, unwanted ... -
GABAergic deficits in absence of LPA1 receptor, associated anxiety-like and coping behaviors, and amelioration by interneuron precursor transplants into the dorsal hippocampus
Rosell-Valle, Cristina; Martínez-Losa, Magdalena; Matas-Rico, Elisa; Castilla-Ortega, María Estela; Zambrana-Infantes, Emma; Gómez-Conde, Ana Isabel; Sánchez-Salido, Lourdes; Ladrón de Guevara-Miranda, David; Pedraza-Benítez, María del Carmen; Serrano-Castro, Pedro Jesús; Chun, Jerold; Rodríguez de Fonseca, Fernando; Álvarez Dolado, Manuel; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (Springer Link, 2021-04-01)
Defects in GABAergic function can cause anxiety- and depression-like behaviors among other neuropsychiatric disorders. Therapeutic strategies using the transplantation of GABAergic interneuron progenitors derived from the ... -
Immune Mechanism of Epileptogenesis and Related Therapeutic Strategies
Aguilar-Castillo, María José; Cabezudo-García, Pablo; Ciano-Petersen, Nicolas Lundahl; García-Martín, Guillermina; Marín-Gracia, Marta; Estivill-Torrús, Guillermo; Serrano-Castro, Pedro Jesús[et al.] (IOAP-MPDI, 2022-03-19)
Immunologic and neuroinflammatory pathways have been found to play a major role in the pathogenesis of many neurological disorders such as epilepsy, proposing the use of novel therapeutic strategies. In the era of personalized ... -
Long- term enhancements in antidepressant efficacy and neurogenesis: Effects of intranasal co- administration of neuropeptide Y 1 receptor (NPY1R) and galanin receptor 2 (GALR2) agonists in the ventral hippocampus
Rasiel, Beltran-Casanueva; Aracelis, Hernández-García; Serrano-Castro, Pedro Jesús; Sánchez-Pérez, José Andrés; Barbancho-Fernández, Miguel Ángel; García-Casares, Natalia; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; Narváez-Peláez, Manuel[et al.] (WILEY, 2024-04-15)
This study evaluates the sustained antidepressant- like effects and neurogenic potential of a 3- day intranasal co- administration regimen of galanin receptor 2 (GALR2) agonist M1145 and neuropeptide ... -
Neuropeptide Y receptor 1 and galanin receptor 2 (NPY1R-GALR2) interactions in the dentate gyrus and their relevance for neurogenesis and cognition
Beltran-Casanueva, Rasiel; Hernández-García, Aracelis; de Amo García, Paula; Blanco-Reina, Encarnación; Serrano-Castro, Pedro; García-Casares, Natalia; Fuxe, Kjell; Borroto-Escuela, Dasiel O.; Narváez, Manuel[et al.] (2024-02-14)
Introduction: This study may unveil novel insights into the interactions between neuropeptide Y receptor 1 (NPY1R) and galanin receptor 2 (GALR2), in the dentate gyrus of the dorsal hippocampus, shedding light on their ... -
Plasma Concentrations of High Mobility Group Box 1 Proteins and Soluble Receptors for Advanced Glycation End-Products Are Relevant Biomarkers of Cognitive Impairment in Alcohol Use Disorder: A Pilot Study.
Rodriguez-de-Fonseca, Fernando; Medina-Paz, Francisco; Sapozhnikov, Mira; Hurtado-Guerrero, Isaac; Rubio-Lamia, Leticia Olga; Martín-de-las-Heras, Stella; Requena-Ocaña, Nerea; Flores-López, María; Fernández-Arjona, María del Mar; Rivera, Patricia; Serrano, Antonia; Serrano-Castro, Pedro Jesús; Zapico, Sara C.; Suárez-Pérez, Juan[et al.] (MDPI (Toxics), 2024)
Alcohol use disorder (AUD) is a major component in the etiology of cognitive decline and dementia. Underlying mechanisms by which long-term alcohol abuse causes cognitive dysfunction include excessive oxidative stress and ... -
Plasma Concentrations of Neurofilament Light Chain Protein and Brain-Derived Neurotrophic Factor as Consistent Biomarkers of Cognitive Impairment in Alcohol Use Disorder
Requena-Ocaña, Nerea; Araos Gómez, Pedro Fernando; Serrano-Castro, Pedro Jesús; Flores-López, María; García-Marchena, Nuria; Oliver-Martos, Begoña; Ruiz-Ruiz, Juan Jesús; Gavito, Ana L.; Pavón-Morón, Francisco Javier; Serrano, Antonia; Mayoral Cleries, Fermín; Suárez-Pérez, Juan; Rodriguez-de-Fonseca, Fernando[et al.] (IOAP-MDPI, 2023-01-07)
For a long time, Substance Use Disorders (SUDs) were not considered a component in the etiology of dementia. The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders introduced substance-induced ... -
Plasma endocannabinoid alterations as a link in the comorbidity of Alzheimer's disease and type 2 diabetes mellitus.
López-Gambero, Antonio J.; Reyes, José Antonio; Fernández-Arjona, María del Mar; Rubio-Lamia, Leticia Olga; Rivera, Patricia; Serrano-Castro, Pedro Jesús; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (2023)
Over the last several years, studies have suggested a role of endocannabinoids such as 2-AG and 2-OG in the impairment of β-cell function and insulin secretion, as well as in the control of lipid and glucose metabolism in ... -
Plasma endocannabinoids as potential biomarkers of type 2 diabetes mellitus in elderly patients with mild cognitive impairment
López-Gambero, Antonio J.; Reyes, José Antonio; Fernández-Arjona, María del Mar; Rubio-Lamia, Leticia Olga; Rivera, Patricia; Serrano-Castro, Pedro Jesús; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (Sociedad Española de Investigación sobre Cannabinoides (SEIC), 2022)
Background: Besides their role in the nervous system and the development of cognitive impairment in elderly patients, compelling evidence suggests that endocannabinoids (ECBs) are related to motivational responses in obesity ... -
Potentiation of antidepressant effects: NPY1R agonist and ketamine synergy enhances TrkB signaling and neurogenesis in the ventral hippocampus
Arrabal-Gómez, Carlos; Serrano-Castro, Pedro; Sánchez-Pérez, José Andrés; Garcia-Casares, Natalia; Fuxe, Kjell; Borroto-Escuela, Dasiel; Narváez, Manuel[et al.] (Taylor & Francis, 2024-04-18)
Background: Major Depressive Disorder (MDD) poses a significant challenge to global health, with current treatments often limited by efficacy and onset delays. This study explores the synergistic antidepressant-like effects ... -
Prognostic Value of Persistent CSF Antibodies at 12 Months in Anti-NMDAR Encephalitis.
Ciano-Petersen, Nicolas Lundahl; Mélisse, Robert; Muñiz-Castrillo, Sergio; Wucher, Valentin; Klich, Amna; Alberto Vogrig, Alberto; Villagrán García, Macarena; Antonio Farina, Antonio; David Goncalves, David; Geraldine Picard, Geraldine; Veronique Rogemond, Veronique; Bastien Joubert, Bastien; Oliver-Martos, Begoña; Serrano-Castro, Pedro Jesús; Maucort-Boulch, Delphine; Honnorat, Jerome[et al.] (American Academy of Neurology, 2023-05-05)
Background and objectives: Anti-NMDA receptor (NMDAR) encephalitis is defined by the presence of antibodies (Abs) targeting the NMDAR in the CSF. This study aimed to determine the prognostic value of persistent CSF NMDAR-Abs ... -
Recombinant soluble type I interferon receptor exerts antiviral activity by inducing proteins related to autophagy
Aliaga-Gaspar, Pablo; Brichette-Mieg, Isabel; Fernández-Arjona, María del Mar; Rodríguez-Bada, José Luis; Lopez-Moreno, Yolanda; Serrano-Castro, Pedro Jesús; Fernández Fernández, Oscar; Ciano-Petersen, Nicolas Lundahl; Oliver-Martos, Begoña[et al.] (Elsevier, 2024)
The soluble type I IFN receptor (sIFNAR2) is produced by alternative splicing and is present in body fluids. Although it can modulate IFN-ß activity, its biological role remains unknown. Methods: An in-silico study was ... -
Synergistic Effects of Intranasally Administered GALR2 and Y1R Agonists on Cognitive and Mood-Related Behaviors in Adult Rats: Implications for Neurodegenerative and Mood Disorders
Moreno Madrid, Isabel; Arrabal-Gómez, José Carlos; Serrano-Castro, Pedro; Díaz-Sánchez, Estela; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel-Ángel; Sánchez-Pérez, José Andrés; Blanco-Reina, Encarnación; Fuxe, Kjell; Borroto-Escuela, Dasiel O.; García-Casares, Natalia; Narváez-Peláez, Manuel[et al.] (2024-06)
Abstract body: Background: The complexity of neurodegenerative and mood disorders necessitates innovative therapeutic strategies beyond current treatments. This study explores the combined therapeutic potential of Galanin ...