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Listar por autor "Serrano-Castro, Pedro Jesús"
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Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis.
Rosell-del-Valle, Cristina; Pedraza-Benítez, María del Carmen; Manuel, Iván; Moreno-Rodríguez, Marta; Rodríguez-Puertas, Rafael; Castilla-Ortega, María Estela; Caramés-Tejedor, José María; Gómez-Conde, Ana Isabel; Zambrana-Infantes, Emma; Ortega-Pinazo, Jesús; Serrano-Castro, Pedro Jesús; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021-06-06)Several studies have demonstrated that lysophosphatidic acid (LPA) acts through its LPA receptors in multiple biological and behavioral processes, including adult hippocampal neurogenesis, hippocampal-dependent memory, and ... -
Effect of Cenobamate on Cognition in Patients with Drug‑Resistant Epilepsy with Focal Onset Seizures: An Exploratory Study
Serrano-Castro, Pedro Jesús; Ramírez-García, Teresa; Cabezudo-García, Pablo; García-Martín, Guillermina; De-La-Parra, Juan (Springer Nature, 2024-01-24)Most second and third generation antiseizure medications (ASMs) are associated with cognitive adverse events, which are a major concern for patients. However, the profile of cognitive adverse events differs between ASMs. ... -
Epilepsia asociada a autoinmunidad: prevalencia y características en pacientes con epilepsia farmacorresistente del lóbulo temporal de etiología desconocida e inicio no reciente.
Cabezudo-García, Pablo (UMA Editorial, 2023)En esta investigación, se determinó la prevalencia de la epilepsia asociada a autoinmunidad (EAA) en pacientes adultos con epilepsia farmacorresistente del lóbulo temporal de etiología desconocida (EFLTED) de inicio no ... -
Immune Mechanism of Epileptogenesis and Related Therapeutic Strategies
Aguilar-Castillo, María José; Cabezudo-García, Pablo; Ciano-Petersen, Nicolas Lundahl; García-Martín, Guillermina; Marín-Gracia, Marta; Estivill-Torrús, Guillermo; Serrano-Castro, Pedro Jesús[et al.] (IOAP-MPDI, 2022-03-19)Immunologic and neuroinflammatory pathways have been found to play a major role in the pathogenesis of many neurological disorders such as epilepsy, proposing the use of novel therapeutic strategies. In the era of personalized ... -
Long- term enhancements in antidepressant efficacy and neurogenesis: Effects of intranasal co- administration of neuropeptide Y 1 receptor (NPY1R) and galanin receptor 2 (GALR2) agonists in the ventral hippocampus
Rasiel, Beltran-Casanueva; Aracelis, Hernández-García; Serrano-Castro, Pedro Jesús; Sánchez-Pérez, José Andrés; Barbancho-Fernández, Miguel Ángel; García-Casares, Natalia; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; Narváez-Peláez, Manuel[et al.] (WILEY, 2024-04-15)This study evaluates the sustained antidepressant- like effects and neurogenic potential of a 3- day intranasal co- administration regimen of galanin receptor 2 (GALR2) agonist M1145 and neuropeptide ... -
Plasma Concentrations of Neurofilament Light Chain Protein and Brain-Derived Neurotrophic Factor as Consistent Biomarkers of Cognitive Impairment in Alcohol Use Disorder
Requena-Ocaña, Nerea; Araos Gómez, Pedro Fernando; Serrano-Castro, Pedro Jesús; Flores-López, María; García-Marchena, Nuria; Oliver-Martos, Begoña; Ruiz-Ruiz, Juan Jesús; Gavito, Ana L.; Pavón-Morón, Francisco Javier; Serrano, Antonia; Mayoral Cleries, Fermín; Suárez-Pérez, Juan; Rodriguez-de-Fonseca, Fernando[et al.] (IOAP-MDPI, 2023-01-07)For a long time, Substance Use Disorders (SUDs) were not considered a component in the etiology of dementia. The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders introduced substance-induced ... -
Plasma endocannabinoid alterations as a link in the comorbidity of Alzheimer's disease and type 2 diabetes mellitus.
López-Gambero, Antonio J.; Reyes, José Antonio; Fernández-Arjona, María del Mar; Rubio-Lamia, Leticia Olga; Rivera, Patricia; Serrano-Castro, Pedro Jesús; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (2023)Over the last several years, studies have suggested a role of endocannabinoids such as 2-AG and 2-OG in the impairment of β-cell function and insulin secretion, as well as in the control of lipid and glucose metabolism in ... -
Plasma endocannabinoids as potential biomarkers of type 2 diabetes mellitus in elderly patients with mild cognitive impairment
López-Gambero, Antonio J.; Reyes, José Antonio; Fernández-Arjona, María del Mar; Rubio-Lamia, Leticia Olga; Rivera, Patricia; Serrano-Castro, Pedro Jesús; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (Sociedad Española de Investigación sobre Cannabinoides (SEIC), 2022)Background: Besides their role in the nervous system and the development of cognitive impairment in elderly patients, compelling evidence suggests that endocannabinoids (ECBs) are related to motivational responses in obesity ... -
Unveiling the Synergistic Interplay of Neuropeptides for Novel Therapeutic Approaches in Neurodegenerative and Depressive Disorders.
Díaz-Sánchez, Estela; López-Salas, Alexander; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel Ángel; Sánchez-Pérez, José Andrés; Blanco-Reina, Encarnación; Brito Rodríguez, Ismel; Serrano-Castro, Pedro Jesús; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; García-Casares, Natalia; Narváez-Peláez, Manuel[et al.] (2023)The intricate relationship between hippocampal neurogenesis dysregulation and neurodegenerative diseases such as Alzheimer's, as well as depression, has sparked an urgent call for innovative therapeutic strategies. Our ...