Listar por autor "Alarcón-Martín, Emilio"
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Drug screening targeting TREM2-TYROBP transmembrane binding.
Cobas-Carreño, María; Esteban-Martos, Alvaro; Tomas-Gallardo, L; Iribarren, I; Gonzalez-Palma, L; Rivera-Ramos, A; Elena-Guerra, J; Alarcón-Martín, Emilio; Ruiz, R; Bravo, MJ; Venero, José Luis; Morató, X; Ruíz, Agustín; Royo-Sánchez-Palencia, José Luis
[et al.] (Spinger Nature, 2025)
TREM2 encodes a microglial membrane receptor involved in the disease-associated microglia (DAM) phenotype whose activation requires the transmembrane interaction with TYROBP. Mutations in TREM2 represent a high-impact risk ... -
Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer’s Disease Aetiopathogenesis in Men
García-González, Pablo; Rojas, Itziar de; Moreno-Grau, Sonia; Montrreal, Laura; Puerta, Raquel; Alarcón-Martín, Emilio; Quintela, Inés; Orellana, Adela; Andrade, Victor; Martino Adami, Pamela V.; Heilmann-Heimbach, Stefanie; Gómez-Garre, Pilar; Periñán, María Teresa; Alvarez, Ignacio; Díez-Fairen, Mónica; Nuñez Llaves, Raul; Olivé Roig, Claudia; García-Ribas, Guillermo; Menéndez-González, Manuel; Martínez, Carmen; Aguilar, Miquel; Buongiorno, Mariateresa; Franco-Macías, Emilio; Saez, Maria Eugenia; Cano, Amanda; Bullido Gómez-Heras, Maria Jesús; Real-Navarrete, Luis Miguel; Rodríguez-Rodríguez, Eloy; Royo-Sánchez-Palencia, José Luis; Álvarez, Victoria; Pastor, Pau; Piñol-Ripoll, Gerard; Mir, Pablo; Calero Lara, Miguel; Medina Padilla, Miguel; Sánchez-Juan, Pascual; Carracedo Álvarez, Ángel María; Valero, Sergi; Hernández, Isabel; Tàrraga, Lluis; Ramirez, Alfredo; Boada, Mercé; Ruiz Laza, Agustín[et al.] (IOAP-MDPI, 2023-01-04)
Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY ... -
Moderate exercise reveals the influence of ACTN3 R577X and ACE I/D polymorphisms on physical performance in non-athlete active subjects
Alvero-Cruz, José Ramón; Alarcón-Martín, Emilio; García-Romero, Jerónimo; Ruiz-Galdón, Maximiliano; Carrillo-de-Albornoz, Margarita; Polvillo, Rocío; González, Irene; Reyes-Engel, Armando; Royo-Sánchez-Palencia, José Luis[et al.] (Elsevier, 2023)
Genome variations contribute to the vast majority of interindividual differences and may decisively influence sports capability. This study was conceived as a means of finding out when exactly polymorphisms start being ... -
The Genetic Research in Alzheimer Disease (GERALD) Initiative Finds rs9320913 as a Neural eQTL of lincRNA AL589740.1
Lopez-Gutierrez, Lidia; García-Alberca, José María; Mendoza, Silvia; Gris, Esther; De la Guía, María Paz; Marin-Carmona, José Manuel; Alarcón-Martín, Emilio; Lobato, Almudena; Cruz-Gamero, Jose Manuel; Cura, Laura; Ocejo, Olga; Torrecilla, Javier; Nieto, María Dolores; Urbano, Concepción; Pareja, Nuria; Luque, Macarena; García-Peralta, María; Carrillejo, Rosario; Royo-Sánchez-Palencia, José Luis[et al.] (Wiley Online Library, 2021)
Alzheimer’s disease is the most common cause of dementia worldwide, and longitudinal studies are crucial to find the factors affecting disease development. Here, we describe a novel initiative from southern Spain designed ... -
Toll-Like Receptor 2 Promoter -196 to -174 Deletion Affects CD4 Levels Along Human Immunodeficiency Virus Infection Progression.
Laplana, Marina; Bravo-Romero, María José; Fernández-Fuertes, Marta; Ruiz-García, Celia; Alarcón-Martín, Emilio; Colmenero Castillo, Juan de Dios; Caruz-Arcos, Antonio; Fibla, Joan; Real-Navarrete, Luis Miguel; Royo-Sánchez-Palencia, José Luis[et al.] (Oxford Academy, 2020)
Toll-like receptor 2 (TLR2) plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter insertion/deletion polymorphism with contradictory data about its ...