Listar por autor "Moreno-González, Inés"
Mostrando ítems 1-20 de 25
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18F-THK5351 PET imaging, neuropathology and clinical progression in a tau mouse model
(Alzheimer disease & Parkinson disease Conference 2021, 2021)Aims: Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. The neuropathology of AD is characterized by the extracellular deposition of ... -
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus.
Sánchez-Varo, Raquel María
; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Torres, Manuel; Baglietto-Vargas, David; Moreno-González, Inés; De Castro, Vanessa; Jiménez, Sebastián; Ruano, Diego; Vizuete, Marisa; Dávila-Cansino, José Carlos; García-Verdugo, José Manuel; Jiménez-Lara, Antonio Jesús; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Springer Nature, 2012)
Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus ... -
Amyloid-b seeding and propagation processes in a hAb-KI model of Alzheimer's disease
Trujillo-Estrada, Laura Isabel; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Cheung, Alwin; Pham Tran, Janine; Núñez-Díaz, Cristina; Forner, Stefania; Martini, Alessandra C.; Da Cunha, Celia; Shahnawaz, Mohammad; Soto, Claudio; Moreno-González, Inés; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2020-12-17)
Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Calretinin Interneurons are Early Targets of Extracellular Amyloid-beta Pathology in PS1/AbetaPP Alzheimer Mice Hippocampus.
Baglietto-Vargas, David; Moreno-González, Inés; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Torres, Manuel; Romero-Acebal, Manuel; Ruano, Diego; Vizuete, Marisa; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (IOS Press, 2010-07-08)
Specific neuronal networks are preferentially affected in the early stages of Alzheimer’s disease (AD). The distinct subpopulations of hippocampal inhibitory GABAergic system have been shown to display differential ... -
Cognitive decline and tau-associated pathology worsen after late-life depression in P301S mice.
Vegas-Gómez, Laura; Gutiérrez-Sastre, Cristina; Arredondo-Alcalá, María Ángeles; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (2024)
Recent studies suggest that depression may be a crucial risk factor for the development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a strong association between late-life depression and AD. ... -
Cognitive impairment acceleration after late-life depression in a model of Alzheimer´s disease
Vegas-Gómez, Laura; López-Castillo, Inés; Fernández-Valenzuela, Juan José; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (2023)
Background: Clinical studies suggest that depressive symptoms could be considered an important risk factor for the future development of cognitive impairment and even Alzheimer's disease (AD). In fact, there is a strong ... -
Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients
Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Gómez-Arboledas, Ángela; García-León, Juan Antonio; Fernández-Valenzuela, Juan José; Mejías-Ortega, Marina; Trujillo-Estrada, Laura Isabel; Baglietto-Vargas, David; Moreno-González, Inés; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Wiley, 2020-03)
Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer's disease (AD). Defective GABAergic neuronal functions may lead to cortical network hyperactivity and ... -
Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer's disease model.
Fernández-Valenzuela, Juan José; Sánchez-Varo, Raquel María; Muñoz-Castro, Clara; De Castro Carratalá, Vanessa; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jimenez, Sebastian; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Moreno-González, Inés; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Springer Nature, 2020-09-08)
In Alzheimer's disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity contributing to neurodegeneration. These diseases are characterized by the intracellular accumulation ... -
Estudio del proceso neurodegenerativo en la corteza entorrinal del modelo transgénico murino PS1M146LxAPP751SLde la enfermedad de Alzheimer
(Universidad de Málaga, Servicio de Publicaciones, 2009) -
Estudio neuropatológico del hipocampo y giro parahipocampal en la enfermedad de Alzheimer: de modelos transgénicos a humanos
Sánchez-Mejías, Elisabeth (Servicio de Publicaciones y Divulgación Científica, 2015)
La actual ausencia de tratamientos efectivos para la enfermedad de Alzheimer (AD) pone de manifiesto la necesidad urgente de caracterizar la evolución de la patología en muestras de pacientes para así entender mejor los ... -
Estudio preclínico de la administración intravenosa de precursores neuronales como terapia para enfermedades neurodegenerativas
(UMA Editorial, 2023-03-14)Las enfermedades de Alzheimer (EA) y Parkinson (EP) son los trastornos neurodegenerativos con mayor prevalencia. Se caracterizan por la acumulación cerebral de proteínas amiloides (Aβ y tau en la EA, y α-sinucleína en la ... -
Evaluation of neuroinflammation as modulator of tau aggregation in response to repetitive mild traumatic brain injury
(CSHL, 2022)The pathological misfolding and aggregation of hyper-phosphorylated tau (ptau) protein in neurofibrillary tangles (NFTs) is the main hallmark of a group of neurodegenerative diseases called tauopathies. These include ... -
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.
Trujillo-Estrada, Laura Isabel; Jiménez, Sebastián; De Castro, Vanessa; Torres, Manuel; Baglietto-Vargas, David; Moreno-González, Inés; Navarro, Victoria; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Springer Nature, 2013)
Background: Alzheimer's disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, ... -
Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer’s Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic.
Jiménez, Sebastián; Baglietto-Vargas, David; Caballero, Cristina; Moreno-González, Inés; Torres, Manuel; Sánchez-Varo, Raquel María; Ruano, Diego; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Society for Neuroscience, 2008)
Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs neurodegeneration) has not yet been resolved. Here, we show the existence of an age-dependent phenotypic ... -
Late-life depression accelerates cognitive decline in a tauopathy mouse model
Vegas-Gómez, Laura; Fernández-Valenzuela, Juan José; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (IBRO/FENS, 2023)
Background: Clinical studies suggest that depressive symptoms could be considered an important risk factor for the future development of cognitive impairment and even Alzheimer's disease (AD). In fact, there is a strong ... -
Late-life depression accelerates cognitive impairment and tau-associated pathology in an Alzheimer´s disease model.
Vegas-Gómez, Laura; Gutiérrez-Sastre, Cristina; Arredondo-Alcalá, María Ángeles; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (2023)
Clinical studies suggest that depression could be considered an important risk factor for the future development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a strong association between late-life ... -
Late-life depression is able to accelerate learning and memory impairment in a mouse model of Alzheimer´s disease
Vegas-Gómez, Laura; López-Castillo, Inés; Fernández-Valenzuela, Juan José; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (CSHL, 2022)
Clinical studies suggest that depression could be considered an important risk factor for the future development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a strong association between late-life ... -
Litio como terapia neuroprotectora en el modelo APPSL/PS1M146L de la enfermedad de Alzheimer.
Trujillo-Estrada, Laura Isabel; Baglietto-Vargas, David; Moreno-González, Inés; De Castro Carratalá, Vanessa; Jiménez, Sebastián; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2013)
El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD). ... -
Longitudinal assessment of tau pet imaging and its correlation with neuropathology and clinical signs progression
(Cold Spring Harbor Laboratory, 2020-12-02)Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. As the world’s population increases, so does the prevalence of age-related dementias. The ...