Listar por autor "Rosell-del-Valle, Cristina"
Mostrando ítems 1-18 de 18
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Absence of LPA1 receptor results in altered pattern of limbic activation after tail suspension test
Moreno-Fernández, Román D.; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita
; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; García-Fernández, María Inmaculada; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (2016-07-20)
Stress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders ... -
The absence of LPA1 receptor results in lipidome dysregulation and Neuropeptide-Y underexpression
Tabbai-Amal, Sara; Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; Fernández, María; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (2018-07-18)
LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signaling molecule. It has been shown that the LPA1 receptor is involved in ... -
Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis.
Rosell-del-Valle, Cristina; Pedraza-Benítez, María del Carmen; Manuel, Iván; Moreno-Rodríguez, Marta; Rodríguez-Puertas, Rafael; Castilla-Ortega, María Estela; Caramés-Tejedor, José María; Gómez-Conde, Ana Isabel; Zambrana-Infantes, Emma; Ortega-Pinazo, Jesús; Serrano-Castro, Pedro Jesús; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021-06-06)
Several studies have demonstrated that lysophosphatidic acid (LPA) acts through its LPA receptors in multiple biological and behavioral processes, including adult hippocampal neurogenesis, hippocampal-dependent memory, and ... -
Cognitive impairment in a murine model of experimental autoimmune encephalomyelitis with relapsing-remitting course
Rosell-del-Valle, Cristina; Sánchez-Morales, Cristina; Gómez-Conde, Ana Isabel; Hurtado-Guerrero, Isaac; Fernández-Fernández, Óscar; Pedraza-Benítez, María del Carmen; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (2015-09-18)
Multiple sclerosis (MS) is a neuroinflammatory disorder characterized by demyelination and progressive axonal loss that affects the central nervous system. In addition of physical disability and the neurodegenerative ... -
Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer’s disease
López-Gambero, Antonio J.; Pacheco-Sánchez, Beatriz; Rosell-del-Valle, Cristina; Medina-Vera, Dina; Navarro, Juan Antonio; Fernández-Arjona, María del Mar; De Ceglia, Marialuisa; Sanjuán-Solís, Jesús Carlos; Simon, Vincent; Cota, Daniela; Rivera, Patricia; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (Elsevier, 2022-06)
Increasing evidence shows that hypothalamic dysfunction, insulin resistance, and weight loss precede and progress along with the cognitive decline in sporadic Alzheimer’s Disease (AD) with sex differences. This study aimed ... -
Effects of palmitoylethanolamide in cocaine-induced behaviours
Santín-Núñez, Luis Javier; Zambrana-Infantes, Emma; Galeano, Pablo; Rosell-del-Valle, Cristina; Ladrón de Guevara-Miranda, David; Castilla-Ortega, María Estela; Rodriguez-de-Fonseca, Fernando; Blanco-Calvo, Eduardo[et al.] (2016-07-13)
Aims. Cocaine addiction is a chronically relapsing disorder characterized by the compulsion to seek and take the drug. Previous investigations have demonstrated that several drugs of abuse, as cocaine, can alter the levels ... -
Enhancing adult hippocampal neurogenesis with lysophosphatidic acid: a proposal for erasing cocaine contextual memory
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2018-06-28)
Stimulating adult hippocampal neurogenesis (AHN) has been uncovered as a promising approach in the manipulation of retrograde memories. This work aims to study whether increasing AHN with lysophosphatidic acid (LPA, an ... -
Evaluación del efecto terapéutico del d-pinitol como modificador multifacético en el curso de la enfermedad de alzheimer.
(UMA Editorial, 2024)La presente tesis doctoral aborda el potencial terapéutico del nutracéutico D-Pinitol (Caromax®-D-Pinitol (DPIN)) en el contexto de la enfermedad de Alzheimer (EA), centrándose en la atenuación de la resistencia a la ... -
LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance.
Moreno-Fernández, R.; Rosell-del-Valle, Cristina; Bacq, Alexandre; Zanoletti, Olivia; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; Gavito, Ana L.; García-Fernández, María Inmaculada; Estivill-Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Sandi, Carmen; Pedraza-Benítez, María del Carmen[et al.] (Neuropharmacology, 2020-03-01)
The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the ... -
Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Wiley, 2019)
Erasing memories of cocaine-stimuli associations might have important clinical implications for addiction therapy. Stimulating hippocampal plasticity by enhancing adult hippocampal neurogenesis (AHN) is a promising strategy ... -
More adult-born dentate gyrus neurons to weaken cocaine-related retrograde memories: an in vivo strategy employing exogenous lysophosphatidic acid
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2019-10-28)
The post-training enhancement of adult hippocampal neurogenesis (AHN) has been receiving growing interest as a potential method to manipulate retrograde memories. Recent hypothesis suggest that the addition of adult-born ... -
Nuevas aproximaciones terapéuticas mediante las vías de señalización del ácido lisofosfatídico: regulación farmacológica y trasplante neuronal
(Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)Los lisofosfolípidos son derivados de fosfolípidos de la membrana celular y uno de los más estudiados es el ácido lisofosfatídico (LPA), considerado como un importante regulador de diversas funciones biológicas. Hasta la ... -
Role of the LPA1 receptor in mood and emotional regulation
Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (2015-09-16)
Depression is a debilitating psychiatric condition characterized by anhedonia and behavioural despair among others symptoms. Despite the high prevalence and devastating impact of depression, underlying neurobiological ... -
Social avoidance and altered stress axis in a mouse model of anxious depression
Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Moreno-Fernández, Román D.; Rosell-del-Valle, Cristina; Pérez-Martín, Margarita; Cifuentes-Rueda, Manuel; García-Fernández, María Inmaculada; Chun, Jerold; Estivill-Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (2018-07-17)
Prevalence of stress-related disorders, such as depression, is raising in modern societies. Indeed, current neurobiological research aims to elucidate the link between deregulation of the hypothalamic-pituitary-adrenal ... -
Stress coping behaviour, brain connectivity and LPA1 receptor: similarities and differences between the genetic and the pharmacological approach
Moreno-Fernández, Román D.; Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Tabbai-Amal, Sara; García-Fernández, María Inmaculada; Chun, Jerold; Pedraza-Benítez, María del Carmen; Rosell-del-Valle, Cristina; Pérez-Martín, Margarita; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier[et al.] (2018-07-16)
LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signalling molecule. It has been recently proposed that this receptor has a ... -
Stress, depression and the hippocampus: modulatory effects of continuous LPA treatment
Moreno-Fernández, Román D.; Bacq, Alexandre; Rosell-del-Valle, Cristina; Zanoletti, Olivia; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; García-Fernández, María Inmaculada; Estivill-Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Sandi, Carmen; Pedraza-Benítez, María del Carmen[et al.] (2019-06-25)
The LPA1, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts may be involved in promoting normal emotional behaviors. Evidence also imply a role for the LPA1 receptor ... -
The limbic brain under stress: a role for the LPA1 receptor
Moreno-Fernández, Román D.; Tabbai-Amal, Sara; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; García-Fernández, María Inmaculada; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen[et al.] (UNED, 2017-07)
Adverse events can impact brain structure and function and are considered primary sources of risk for depression, anxiety, and other psychiatric disorders. In this sense, the neurobiological circuitry in charge of dealing ... -
What role does the LPA1 receptor play in regulating emotional-like behaviours?
Pedraza-Sánchez-López, J.; Castilla-Ortega, María Estela; Rosell-del-Valle, Cristina; Moreno-Fernández, Román D.; Zambrana-Infantes, Emma; García-Fernández, María Inmaculada; Rodriguez-de-Fonseca, Fernando; Chun, Jerold; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier[et al.] (2015-07-24)
The LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts as an intercellular signalling molecule. It has been proposed that this receptor has a role ...