Listar por autor "Leyva-Fernández, Laura"
Mostrando ítems 1-20 de 44
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Activation of the JAK-STAT Signaling Pathway after In Vitro Stimulation with IFN beta in Multiple Sclerosis Patients According to the Therapeutic Response to IFN beta
Hurtado-Guerrero, Isaac; Pinto-Medel, María-Jesús; Urbaneja, Patricia; Rodríguez-Bada, José Luis; León, Antonio; Guerrero, Miguel; Fernández-Fernández, Óscar; Leyva-Fernández, Laura; Oliver-Martos, Begoña
[et al.] (Public Library of Science, 2017)
Interferon beta (IFNß) is a common treatment used for multiple sclerosis (MS) which acts through the activation of the JAK-STAT pathway. However, this therapy is not always effective and currently there are no reliable ... -
Anticonvulsant-induced Toxic Epidermal Necrolysis: Monitoring the Immunologic Response.
Leyva-Fernández, Laura; Torres-Jaén, María Josefa; Posadas, Sinforiano Jose; Blanca, Miguel; Besso, Guillermo; O'Valle, Francisco; García del Moral, Raimundo; Santamaría, Luis F; Juárez, Carlos[et al.] (Elsevier BV, 2000)
Background Toxic epidermal necrolysis is a severe reaction with skin involvement induced by different drugs and other agents. The mechanisms implicated in the induction of the reaction are poorly understood. Objective To ... -
Antiviral, Immunomodulatory and Antiproliferative Activities of Recombinant Soluble IFNAR2 without IFN-ß Mediation
Hurtado-Guerrero, Isaac; Hernáez, Bruno; Pinto-Medel, Maria Jesús; Calonge, Esther; Rodríguez-Bada, José Luis; Urbaneja, Patricia; Alonso, Ana; Mena-Vázquez, Natalia; Aliaga, Pablo; Issazadeh-Navikas, Shohreh; Pavía-Molina, José; Leyva-Fernández, Laura; Alcamí, José; Alcamí, Antonio; Fernández-Fernández, Óscar; Oliver-Martos, Begoña[et al.] (MDPI, 2020)
Soluble receptors of cytokines are able to modify cytokine activities and therefore the immune system, and some have intrinsic biological activities without mediation from their cytokines. The soluble interferon beta (IFN-ß) ... -
Candidate Gene Study of TRAIL and TRAIL Receptors: Association with Response to Interferon Beta Therapy in Multiple Sclerosis Patients
López-Gómez, Carlos; Pino-Ángeles, Almudena; Órpez-Zafra, Teresa; Pinto-Medel, Mª Jesús; Oliver-Martos, Begoña; Ortega-Pinazo, Jesús; Arnáiz, Carlos; Guijarro-Castro, Cristina; Varadé, Jezabel; Alvarez-Lafuente, Roberto; Urcelay, Elena; Sánchez-Jiménez, Francisca María; Fernández Fernández, Oscar; Leyva-Fernández, Laura[et al.] (Public Library of Sciences, 2013)
TRAIL and TRAIL Receptor genes have been implicated in Multiple Sclerosis pathology as well as in the response to IFN beta therapy. The objective of our study was to evaluate the association of these genes in relation to ... -
Control de la Biocontaminación en zonas de ambiente clasificado destinadas a la fabricación aséptica de medicamentos de Terapias Avanzadas
(UMA Editorial, 2017-08-28)Los recientes progresos científicos alcanzados en campos como la biotecnología celular y molecular han permitido el desarrollo de alternativas terapéuticas novedosas y prometedoras como las Terapias Avanzadas (terapia ... -
Controlled administration of penicillin to patients with a positive history but negative skin and specific serum IgE tests.
Torres-Jaén, María Josefa; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; Guzmán, Antonio-Eloy; Cornejo García, José Antonio; Juárez, Carlos; Blanca, Miguel[et al.] (Wiley, 2002)
Although subjects with a positive history of immediate allergy to penicillin and negative skin test are considered to tolerate penicillin, they may develop an immediate reaction despite negative skin and serum specific IgE ... -
Cross-reactivity of antibodies against interferon beta in multiple sclerosis patients and interference of the JAK-STAT signaling pathway
Hurtado-Guerrero, Isaac; Pinto-Medel, Maria Jesus; Urbaneja, Patricia; Rodríguez-Bada, José Luis; Ortega-Pinazo, Jesús; Serrano-Castro, Pedro Jesús; Fernández-Fernández, Óscar; Leyva-Fernández, Laura; Oliver-Martos, Begoña[et al.] (Nature, 2017)
Interferon beta (IFNβ) therapy has immunogenic properties and induces the development of neutralizing antibodies (NAbs). From the extensive literature focused in the development of NAbs in multiple sclerosis (MS) patients, ... -
Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker
Órpez-Zafra, Teresa; Pavía-Molina, José; Hurtado-Guerrero, Isaac; Pinto-Medel, Maria Jesús; Rodríguez-Bada, José Luis; Urbaneja, Patricia; Suardíaz García, Margarita; Villar, Luisa M; Comabella, Manuel; Montalban, Xavier; Alvarez-Cermeño, Jose C; Leyva-Fernández, Laura; Fernández-Fernández, Óscar; Oliver-Martos, Begoña[et al.] (SAGE Journals, 2017)
Background: The soluble isoform of the interferon-β (IFN-β) receptor (sIFNAR2) could modulate the activity of both endogenous and systemically administered IFN-β. Previously, we described lower serum sIFNAR2 levels in ... -
Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity.
Posadas, Sinforiano Jose; Padial, Antonia; Torres-Jaén, María Josefa; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; Sánchez, Elena; Álvarez, Javier; Romano, Antonino; Juárez, Carlos; Blanca, Miguel; Sánchez, Elena[et al.] (Elsevier, 2002)
Background Drugs can induce different immunologic reactions; T-cell mediated responses produce the most severe reactions. Although in vitro studies show that T cells recognize drugs or their metabolites and induce an ... -
Development and validation of an ELISA for quantification of soluble IFN-β receptor: assessment in multiple sclerosis
Órpez-Zafra, Teresa; Pavía-Molina, José; Pinto-Medel, Maria Jesús; Hurtado-Guerrero, Isaac; Rodríguez-Bada, José Luis; Martín-Montañez, Elisa; Fernández Fernández, Óscar; Leyva-Fernández, Laura; Oliver-Martos, Begoña[et al.] (Taylor & Francis, 2015)
Aim: The soluble isoform of the IFN-β receptor (sIFNAR2) can bind IFN-β and modulate its activity, although its role in autoimmune diseases remains unknown. Methods: A recombinant human sIFNAR2 protein was cloned, ... -
DQB1*0602 allele shows a strong association with multiple sclerosis in patients in Malaga, Spain.
Fernández-Fernández, Óscar; Fernández, Victoria; Alonso, Antonio; Caballero-González, Abelardo; Luque, Gloria; Bravo, Mariano; León-Martín, Antonio; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; De Ramón Garrido, Enrique[et al.] (Springer, 2004-04)
Background The human leukocyte antigen (HLA) class II DR2 haplotype (DRB1*1501, DQA1*0102, DQB1*0602) has been associated with multiple sclerosis (MS) in all ethnic groups and very strongly in Caucasians. Aim To investigate ... -
Early development of anti-natalizumab antibodies in MS patients
Oliver-Martos, Begoña; Órpez, Teresa; Urbaneja, Patricia; Maldonado-Sanchez, Rafael; Leyva-Fernández, Laura; Fernández Fernández, Óscar[et al.] (SpringerLink, 2013)
The purpose of this study is to monitor the development of anti-natalizumab antibodies to evaluate their first appearance in multiple sclerosis patients, since their presence has been associated with a reduction in the ... -
Effects of the multiple sclerosis associated -330 promoter polymorphism in IL2 allelic expression
(Elsevier BV, 2004)The -330 IL2 gene promoter polymorphism has been associated with multiple sclerosis (MS) [J. Neuroimmunol. 119 (2001) 101], but the basis underlying this association remains unknown to date. In the present work, we have ... -
Expression of the skin-homing receptor in peripheral blood lymphocytes from subjects with nonimmediate cutaneous allergic drug reactions
Blanca, Miguel; Posadas, Sinforiano Jose; Torres-Jaén, María Josefa; Leyva-Fernández, Laura; Mayorga Mayorga, Cristobalina; González, Lourdes; Juárez, Carlos; Fernández, Javier; Santamaría, Luis F[et al.] (Wiley, 2000)
Background: In nonimmediate cutaneous reactions to drugs, the skin is the organ most frequently involved, and T lymphocytes may play a relevant role. T cells related to skin immune responses express the cutaneous ... -
Gene expression in IFNß signalling pathway differs between monocytes, CD4 and CD8 T cells from MS patients
Oliver-Martos, Begoña; Órpez, Teresa; Pinto-Medel, Maria Jesús; Mayorga Mayorga, Cristobalina; García-León, Juan Antonio; Maldonado-Sanchez, Rafael; Suardíaz García, Margarita; Guerrero, Miguel; Luque, Gloria; Leyva-Fernández, Laura; Fernández Fernández, Óscar[et al.] (Elsevier, 2011)
IFNß exerts its activity through the interaction with IFNAR, through activation of the JAK/STAT pathway. We analyzed the changes in IFNAR1, IFNAR2, STAT1, STAT2, Tyk2, JAK1, IRF9 and MxA gene expressions after prolonged ... -
Gene therapy with mesenchymal stem cells expressing IFN-ß ameliorates neuroinflammation in experimental models of multiple sclerosis
Marín Bañasco, Carmen; Benabdellah, K; Melero-Jerez, C; Oliver-Martos, Begoña; Pinto-Medel, Maria Jesús; Hurtado-Guerrero, Isaac; de Castro, Fernando; Clemente, Diego; Fernández-Fernández, Óscar; Martín, F; Leyva-Fernández, Laura; Suardíaz García, Margarita[et al.] (British Pharmacological Society, 2017)
Background and purpose: Recombinant IFN-ß is one of the first-line treatments in multiple sclerosis (MS), despite its lack of efficacy in some patients. In this context, mesenchymal stem cells (MSCs) represent a promising ... -
Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1
(Public Library of Science, 2012)Multiple Sclerosis (MS) is the most common progressive and disabling neurological condition affecting young adults in the world today. From a genetic point of view, MS is a complex disorder resulting from the combination ... -
HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain)
Fernández Fernández, Óscar; Rodríguez-Antigüedad, Alfredo; Pinto-Medel, María Jesús; Mendibe, Mari Mar; Acosta, Nestor; Oliver-Martos, Begoña; Guerrero, Miguel; Papais-Alvarenga, Marcos; Fernández Sánchez, Victoria Eugenia; Leyva-Fernández, Laura[et al.] (Springer, 2009)
Genetic susceptibility to multiple sclerosis (MS) is associated with genes of the major histocompatibility complex, particularly with the HLA DRB1*1501-DQA1*0102-DQB1*0602 haplotype in Caucasians. To investigate the ... -
Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis.
Alcina, Antonio; Fedetz, María; Fernández, Óscar; Saiz, Albert; Izquierdo, Guillermo; Lucas, Miguel; Leyva-Fernández, Laura; García-León, Juan Antonio; Abad-Grau, María del Mar; Alloza, Iraide; Antigüedad, Alfredo; Garcia-Barcina, María Jesús; Vandenbroeck, Koen; Varadé, Jezabel; de la Hera, Belén; Arroyo, Rafael; Comabella, Manuel; Montalban, Xavier; Petit-Marty, Natalia; Navarro, Arcadi; Otaegui, David; Olascoaga, Javier; Blanco, Yolanda; Urcelay, Elena; Matesanz, Fuencisla[et al.] (BMJ Journals, 2013-01)
Background and aim: Several studies have highlighted the association of the 12q13.3-12q14.1 region with coeliac disease, type 1 diabetes, rheumatoid arthritis and multiple sclerosis (MS); however, the causal variants ... -
IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response
Leyva-Fernández, Laura; Fernández Fernández, Óscar; Fedetz, María; Blanco, Eva; Fernández Sánchez, Victoria Eugenia; Oliver-Martos, Begoña; León, Antonio; Pinto-Medel, María-Jesús; Mayorga Mayorga, Cristobalina; Guerrero, Miguel; Luque, Gloria; Alcina, Antonio; Matesanz, Fuencisla[et al.] (Elsevier, 2005)
We investigated the role of three polymorphisms in the IFNAR1 (SNPs 18417 and -408) and IFNAR2 (SNP 11876) genes in multiple sclerosis (MS) susceptibility and in the IFNbeta treatment response in a group of 147 patients ...