Listar por autor "Alén, Francisco"
Mostrando ítems 1-7 de 7
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The dopaminergic mesolimbic system are involved in the anhedonic-like effects produced by galanin (1-15) in rats.
Cantero-García, Noelia; García-Durán, Laura
; Gago-Calderón, Belén; Flores-Burgess, Antonio; Alén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo; García-Durán, Laura[et al.] (2019-09-10)
Galanin (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in several behavioural tests. Recently, we described that GAL(1-15) induces an anhedonic-like effect in saccharine self-administration and sucrose ... -
The effect of Galanin N-Terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; García-Durán, Laura; Cantero-García, Noelia; Alén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2019-11-18)
The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioral tests and these effects were significantly stronger than the ones induced by Galanin. Since anhedonia is a ... -
Effects of Galanin N-Terminal fragment (1-15) in the anhedonic behavioural tests in rats.
García-Cantero, Noelia; Flores-Burgess, Antonio; Gago-Calderón, Belén; García-Durán, Laura; Alén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2021-01-22)
The Galanin N-terminal fragment (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioural tests in rats. Since anhedonia is a core feature of depression, we have analyzed GAL(1-15) actions in ... -
LPA1/3 receptor antagonist KI16425 as a novel treatment for the neurobehavioural effects of the ethanol
Ladrón de Guevara-Miranda, David; Sánchez-Marín, Laura; Alén, Francisco; Moreno-Fernández, Román D.; García-Fernández, María Inmaculada; Gil Rodríguez, Sara; Gavito, Ana L.; García-Marchena, Nuria; Pedraza-Benítez, María del Carmen; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Serrano, Antonia; Castilla-Ortega, María Estela[et al.] (2017-07-24)
Aims. The lysophosphatidic acid (LPA) is an ubiquitous lysophospholipid that acts through G-protein coupled receptors (LPA1-6), and it is involved in the modulation of emotional and motivational behaviors. Recent literature ... -
Sudden cessation of fluoxetine before alcohol drinking reinstatement alters microglial morphology and TLR4/inflammatory neuroadaptation in the rat brain
Aranda, Jesús; Fernández-Arjona, María del Mar; Alén, Francisco; Rivera, Patricia; Rubio, Leticia; Smith-Fernández, Inés María[et al.] (SPRINGER, 2021-07-08)
Preclinical studies on the efects of abrupt cessation of selective serotonin reuptake inhibitors (SSRIs), a medication often prescribed in alcohol use disorder (AUD) patients with depression, results in alcohol consumption ... -
Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior
Sánchez-Marín, Laura; Ladrón de Guevara-Miranda, David; Mañas-Padilla, María del Carmen; Alén, Francisco; Moreno-Fernández, Román D.; Díaz-Navarro, Caridad; Pérez-del Palacio, José; García-Fernández, María Inmaculada; Pedraza-Benítez, María del Carmen; Pavón, Francisco Javier; Rodríguez de Fonseca, Fernando; Santín-Núñez, Luis Javier; Serrano, Antonia; Castilla-Ortega, María Estela[et al.] (Elsevier, 2018-05-01)
The systemic administration of lysophosphatidic acid (LPA) LPA1/3 receptor antagonists is a promising clinical tool for cancer, sclerosis and fibrosis-related diseases. Since LPA1 receptor-null mice engage in increased ...