Listar por autor "Gago-Calderón, Belén"
Mostrando ítems 1-20 de 58
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A model of increased impulsivity in rats with bilateral parkinsonism treated with Pramipexole
Gago-Calderón, Belén
; Jiménez-Urbieta, Haritz; Marín, Concepció; Quiroga-Varela, Ana; Delgado-Alvarado, Manuel; Rodríguez-Oroz, María Cruz[et al.] (2016)
Impulse control disorders (ICD) is a common side effect of the dopaminergic treatment in patients with Parkinson's disease, which is more associated with dopamine agonists than with levodopa. To understand its pathophysiology, ... -
A service-learning educational approach developed the transversal competencies of undergraduate students in an outreach workshop aimed to high school students
In the last decade, research institutes and universities have strengthened the development of outreach activities in the biomedical field, involving researchers and professors as well as graduate students, but with little ... -
Antidepressant-like effects induced by galanin 2/neuropeptide Y Y1 heterodimers in the dentate gyrus of the hippocampus
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo; Gago-Calderón, Belén; Flores-Burgess, Antonio; Santín-Núñez, Luis Javier; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2017-08-30)
Previously, we have described the Galanin (GAL) and Neuropeptide Y Y1 (NPYY1) interactions through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers in the Dentate Gyrus (DG) of the Hippocampus, using ... -
Antioxidant and neuroprotective actions of IGF-II against glucocorticoid-induced toxicity in dopaminergic neurons.
Claros-Gil, Silvia; Valverde Moreno, Nadia; Zamorano-González, Pablo; Romero-Zerbo, Silvana Yanina; Lara Fernández, Estrella; Boraldi, Federica; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (2023)
The neurodegenerative Parkinson’s disease (PD) affects 1–3% of the population aged over 65. A wide range of pathways and mechanisms are involved in its pathogenesis, such as oxidative stress, mitochondrial dysfunction, ... -
Cocaine detrimentally affects mitochondrial functionality and cell viability in dopaminergic neurons.
Zamorano-González, Pablo; Bandini, Luca; Valverde, Nadia; Claros-Gil, Silvia; Romero-Zerbo, Silvana Yanina; Lara, Estrella; Santín-Núñez, Luis Javier; Martín-Montañez, Elisa; Gago-Calderón, Belén; García-Fernández, María Inmaculada[et al.] (2024)
An elevated consumption of cocaine (benzoylmethylecgonine), which causes anesthetic and stimulant effects on the central nervous system, may be associated with several neurodegenerative conditions affecting dopaminergic ... -
Different susceptibility to pramipexole-induced impulsivity in a rat model of parkinson’s disease
Jiménez-Urbieta, Haritz; Merino-Galan, Leire; Rodriguez-Chinchilla, Tatiana; Belloso-Iguerategui, Arantzatzu; Delgado-Alvarado, Manuel; Navalpotro-Gómez, Irene; Quiroga-Varela, Ana; Gago-Calderón, Belén; Rodríguez-Oroz, María Cruz[et al.] (2019-09-12)
Impulse Control Disorders (ICD) in patients with Parkinson’s disease are abnormal behaviors caused by long-term use of dopamine agonists, which pathophysiology is poorly understood. Using parkinsonian rats (adeno-associated ... -
Dopamine D4 receptor activation counteracts nigrostriatal pathway activation by morphine: relevance in drug addiction.
Rivera-Ramírez, Alicia; Suárez-Boomgaard, Diana; Gago-Calderón, Belén; Valderrama-Carvajal, Alejandra; Medina-Luque, José; Roales-Buján, Ruth; Fuxe, Kjell; De-la-Calle-Martín, Adelaida[et al.] (2013)
Morphine induces dopamine release in the caudate putamen (CPu), which promotes stereotyped behavior and habit learning for drug-seeking and –taking. Nigrostriatal pathway stimulation by morphine is due to a removal of tonic ... -
Dopamine D4R restores morphine-induced impairment of adult neurogenesis in the subventricular zone
Gago-Calderón, Belén; Real-Avilés, María Ángeles; Ponce-Velasco, Marina; Rivera-Ramírez, Alicia (2021)
In the adult mammalian brain, neuroblasts from the subventricular zone (SVZ) migrate along the rostral migratory stream into the olfactory bulb, where they differentiate and synaptically integrate to contribute with the ... -
The dopaminergic mesolimbic system are involved in the anhedonic-like effects produced by galanin (1-15) in rats.
Cantero-García, Noelia; García-Durán, Laura; Gago-Calderón, Belén; Flores-Burgess, Antonio; Alén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo; García-Durán, Laura[et al.] (2019-09-10)
Galanin (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in several behavioural tests. Recently, we described that GAL(1-15) induces an anhedonic-like effect in saccharine self-administration and sucrose ... -
Dorsolateral Periaqueductal Grey Matter in the control of laryngeal activity and subglottic pressure in spontaneously breathing anaesthetized rats.
González-García, Marta; Carrillo-Franco, Laura; Morales-Luque, Carmen; Díaz-Casares, Amelia; Ponce-Velasco, Marina; Gago-Calderón, Belén; Dawid-Milner, Marc Stefan; López-González, Manuel Víctor[et al.] (2023)
The stimulation of the dlPAG produces vocalization. The nRA turn passive into active expiration modifying the activity of laryngeal motoneurons located in the nA. We have shown that cPB and A5 Region are involved in changes ... -
Efecto del factor de crecimiento insulínico tipo II sobre el daño oxidativo y neuronal en modelos de la enfermedad de Parkinson.
(UMA Editorial, 2024)La enfermedad de Parkinson (EP) es una enfermedad neurodegenerativa crónica y progresiva que se caracteriza por el desarrollo de una sintomatología que repercute tanto en la capacidad motora del afectado, que se caracteriza ... -
The effect of Galanin N-Terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; García-Durán, Laura; Cantero-García, Noelia; Alén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2019-11-18)
The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioral tests and these effects were significantly stronger than the ones induced by Galanin. Since anhedonia is a ... -
Effects of galanin n-terminal fragment (1-15) in sac- charin self-administration and sucrose preference test in rats.
García-Durán, Laura; Cantero-García, Noelia; Flores-Burgess, Antonio; Gago-Calderón, Belén; Allén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2019-09-12)
The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions in several behavioral tests, and these effects were significantly stronger than the ones induced by Galanin (1-29). Since, ... -
Effects of Galanin N-Terminal fragment (1-15) in the anhedonic behavioural tests in rats.
García-Cantero, Noelia; Flores-Burgess, Antonio; Gago-Calderón, Belén; García-Durán, Laura; Alén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2021-01-22)
The Galanin N-terminal fragment (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioural tests in rats. Since anhedonia is a core feature of depression, we have analyzed GAL(1-15) actions in ... -
Encapsulación de neuropéptidos mediante la técnica de co-flujo
(2018-03-22)Muchas enfermedades del sistema nervioso central (SNC) pueden ser tratadas dirigiendo fármacos a esta zona del cuerpo. Sin embargo, el camino hacia el encéfalo se ve obstaculizado por una serie de factores, constituyendo ... -
Encapsulación de neuropéptidos mediante la técnica de Electrospraying & Electrospinning coaxial
(2018-03-22)La barrera hematoencefálica (BHE) es una estructura con permeabilidad selectiva que no permite el paso de multitud de sustancias al sistema nervioso central (SNC). Algunos neuropéptidos, como la galanina, y fármacos que ... -
Exploring laryngeal effects of dorsolateral periaqueductal grey stimulation in anesthetized rats: implications for c-Fos and FOXP2 expression in the nucleus ambiguus subdivisions.
Carrillo-Franco, Laura; González-García, Marta; Morales-Luque, Carmen; Díaz-Casares, Amelia; Ponce-Velasco, Marina; Gago-Calderón, Belén; Dawid-Milner, Marc Stefan; López-González, Manuel Víctor[et al.] (2024)
Stimulation of the Periaqueductal Gray matter (PAG) and nucleus retroambiguus (nRA) evokes vocalization (1). The nRA serves as a key target for converting passive into active expiration by modulating the activity of laryngeal ... -
Galanin (1-15) enhancement of the behavioral effects of a 5-HT1AR agonist and fluoxetine in the forced swimming test gives a new therapeutic strategy against depression: possible role of GALR1-GALR2-5-HT1AR heteroreceptor complexes
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Puigcerver-Martínez, Araceli; Gago-Calderón, Belén; García-Durán, Laura; Cantero-García, Noelia; Narváez-Bueno, José Ángel; Santín-Núñez, Luis Javier; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2019-06-17)
Major Depression is the most frequent mood disorder, with a lifetime prevalence that has been reported to range from 7% to 21%. It is associated with a substantial functional impairment, diminished quality of life, increased ...