Listar por autor "Clemente-Postigo, María Mercedes"
Mostrando ítems 1-18 de 18
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8-oxoguanine DNA glycosylase 1 upregulation as a risk factor for obesity and colorectal cancer
Pilo, Jesús; García-Flores, Libia Alejandra; Clemente-Postigo, María Mercedes
; Arranz-Salas, Isabel María; Alcaide, Julia; Ramos-Fernandez, Maria; Lozano-Castro, José; Boughanem Lakhal, Hatim; Kompella, Pallavi; Macías-González, Manuel[et al.] (MDPI, 2023-03-13)
DNA damage has been extensively studied as a potentially helpful tool in assessing and preventing cancer, having been widely associated with the deregulation of DNA damage repair (DDR) genes and with an increased risk of ... -
Adipogenic Impairment of Adipose Tissue-Derived Mesenchymal Stem Cells in Subjects With Metabolic Syndrome: Possible Protective Role of FGF2
Oliva Olivera, Wilfredo; Coín-Aragüez, Leticia I.; Lhamyani, Said; Clemente-Postigo, María Mercedes; Alcaide Torres, Juan; Bernal-López, María Rosa; El-Bekay, Rajaa; Tinahones-Madueño, Francisco José[et al.] (Endocrine Society, 2017)
Context: The decreased expansion capacity of adipose tissue plays a crucial role in the onset of disorders associated with metabolic syndrome. Objetive: The aim of this study was to examine the state of adipose tissue-derived ... -
Adipose tissue gene expression of factors related to lipid processing in obesity
Clemente-Postigo, María Mercedes; Queipo Ortuño, María Isabel; Fernandez-García, Diego; Gómez-Huelgas, Ricardo; Tinahones, Francisco J; Cardona, Fernando[et al.] (PLOS One, 2011)
Background Adipose tissue lipid storage and processing capacity can be a key factor for obesity-related metabolic disorders such as insulin resistance and diabetes. Lipid uptake is the first step to adipose tissue lipid ... -
Adipose tissue inflammation and VDR expression and methylation in colorectal cancer
Castellano-Castillo, Daniel; Morcillo Espina, Sonsoles; Clemente-Postigo, María Mercedes; Crujeiras Martínez, Ana Belén; Fernández-García, José Carlos; Torres Sánchez, Esperanza; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (BMC (Part of Springer Nature), 2018)
Background: Lack of vitamin D (VD) has been associated with colorectal cancer (CRC). VD has anti-inflammatory effects and regulates several cellular pathways by means of its receptor, including epigenetic modifications. ... -
Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer
Boughanem, Hatim; Cabrera-Mulero, Amanda; Hernández Alonso, Daniel; Clemente-Postigo, María Mercedes; Casanueva, Felipe F.; Tinahones-Madueño, Francisco José; Morcillo Espina, Sonsoles; Crujeiras Martínez, Ana Belén; Macías-González, Manuel[et al.] (Springer Nature, 2020)
Colorectal cancer (CRC) results from the accumulation of epigenetic and genetic changes in colon cells during neoplasic transformation, which the activation of Wingless (Wnt) signaling pathway is a common mechanism for CRC ... -
Effect of acute and chronic red wine consumption on lipopolysaccharide concentrations
Clemente-Postigo, María Mercedes; Queipo-Ortuño, María Isabel; Boto-Ordóñez, María; Coín-Aragüez, Leticia I.; Roca-Rodríguez, María del Mar; Delgado-Lista, J.; Cardona-Díaz, Fernando; Andrés-Lacueva, Cristina; Tinahones-Madueño, Francisco José[et al.] (Elsevier (The American Journal of Clinical Nutrition), 2013)
Background: Chronic red wine (RW) consumption has been associated with decreased cardiovascular disease risk, mainly attributed to an improvement in lipid profile. RW intake is also able to change the composition of gut ... -
Effect of apolipoprotein C3 and apolipoprotein A1 polymorphisms on postprandial response to a fat overload in metabolic syndrome patients
Clemente-Postigo, María Mercedes; Queipo-Ortuño, María Isabel; Valdivieso-Felices, Pedro; Tinahones-Madueño, Francisco José; Cardona-Díaz, Fernando (Elsevier. The Canadian Society of Clinical Chemists., 2010)
Objectives: Apolipoprotein C-III (APOC3) is a component of triglyceride rich lipoproteins, and SstI polymorphism has been associated with hypertriglyceridemia. Apolipoprotein A-I (APOA1) is the major component of HDL and ... -
Effects of glucagon-like peptide-1 on the differentiation and metabolism of human adipocytes.
El-Bekay, Rajaa; Coín-Aragüez, Leticia I.; Fernandez-García, Diego; Oliva Olivera, Wilfredo; Bernal-López, María Rosa; Clemente-Postigo, María Mercedes; Delgado-Lista, Javier; Díaz-Ruiz, Alberto; Guzmán-Ruiz, Rocio; Vázquez-Martínez, Rafael; Lhamyani, Said; Roca-Rodríguez, María del Mar; Fernández-Veledo, Sonia; Vendrell, Joan; Malagón, Maria M.; Tinahones-Madueño, Francisco José[et al.] (British Pharmacological Society, 2016-03-18)
Glucagon-like peptide-1 (GLP-1) analogues improve glycaemic control in type 2 diabetic (T2D) patients and cause weight loss in obese subjects by as yet unknown mechanisms. We recently demonstrated that the GLP-1 receptor, ... -
Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients
Clemente-Postigo, María Mercedes; Queipo-Ortuño, María Isabel; Murri, Mora; Boto-Ordóñez, María; Pérez-Martínez, Pablo; Andrés-Lacueva, Cristina; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José[et al.] (American Society for Biochemistry and Molecular Biology, 2012)
The low-grade inflammation observed in obesity has been associated with a high-fat diet, though this relation is not fully understood. Bacterial endotoxin, produced by gut microbiota, may be the linking factor. However, ... -
FABP4 Dynamics in Obesity: Discrepancies in Adipose Tissue and Liver Expression Regarding Circulating Plasma Levels
Queipo-Ortuño, María Isabel; Escoté Miró, Xavier; Ceperuelo-Mallafré, Victoria; Garrido-Sánchez, Lourdes; Miranda, Merce; Clemente-Postigo, María Mercedes; Pérez-Pérez, Rafael; Peral Fuentes, Belén; Cardona-Díaz, Fernando; Fernández Real, José M; Tinahones-Madueño, Francisco José; Vendrell Ortega, Joan[et al.] (PLOS (Public Library of Science), 2012)
Background FABP4 is predominantly expressed in adipose tissue, and its circulating levels are linked with obesity and a poor atherogenic profile. Objective In patients with a wide BMI range, we analyze FABP4 expression ... -
Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers
Queipo-Ortuño, María Isabel; Boto-Ordóñez, María; Murri Pierri, Mora; Gómez-Zumaquero, Juan Miguel; Clemente-Postigo, María Mercedes; Estruch, Ramón; Cardona-Díaz, Fernando; Andrés-Lacueva, Cristina; Tinahones-Madueño, Francisco José[et al.] (Elsevier (American Society for Nutrition), 2012)
Background: Few studies have investigated the effect of dietary polyphenols on the complex human gut microbiota, and they focused mainly on single polyphenol molecules and select bacterial populations. Objective: The ... -
Lipopolysaccharide and lipopolysaccharide-binding protein levels and their relationship to early metabolic improvement after bariatric surgery
Clemente-Postigo, María Mercedes; Roca-Rodríguez, María del Mar; Camargo, Antonio; Ocaña-Wilhelmi, Luis Tomás; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José[et al.] (Elsevier (American Society for Metabolic and Bariatric Surgery), 2015)
Background: Bariatric surgery usually results in metabolic improvements within a few days from intervention, but the underlying mechanism is not completely understood and may vary depending on the bariatric procedure. ... -
Metabolic endotoxemia promotes adipose dysfunction and inflammation in human obesity
Clemente-Postigo, María Mercedes; Oliva Olivera, Wilfredo; Coín-Aragüez, Leticia I.; Ramos-Molina, Bruno; Giráldez-Pérez, Rosa María; Lhamyani, Said; Alcaide Torres, Juan; Pérez-Martínez, Pablo; El Bekay Rizky, Rajaa; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José[et al.] (American Physiological Society, 2019)
Impaired adipose tissue (AT) lipid handling and inflammation is associated with obesity-related metabolic diseases. Circulating lipopolysaccharides (LPSs) from gut microbiota (metabolic endotoxemia), proposed as a triggering ... -
miR-20b, miR-296, and Let-7f Expression in Human Adipose Tissue is Related to Obesity and Type 2 Diabetes.
Gentile, Adriana Mariel; Lhamyani, Said; Coín-Aragüez, Leticia I.; Clemente-Postigo, María Mercedes; Oliva Olivera, Wilfredo; Romero-Zerbo, Silvana Yanina; García Serrano, Sara; García-Escobar, Eva; Zayed, Hatem; Doblado, Esther; Bermúdez Silva, Francisco Javier; Murri, Mora; Tinahones-Madueño, Francisco José; El-Bekay, Rajaa[et al.] (Wiley, 2019)
Objective: This study aimed to analyze the potential association of different microRNA (miRNA) moleculeswith both type 2 diabetes (T2D) and obesity and determine their target genes.Methods: Quantitative PCR was used to ... -
Postprandial hypertriglyceridemia predicts improvement in insulin resistance in obese patients after bariatric surgery.
Tinahones-Madueño, Francisco José; Queipo Ortuño, Maria Isabel; Clemente-Postigo, María Mercedes; Fernandez-García, Diego; Mingrone, Geltrude; Cardona-Díaz, Fernando[et al.] (Elsevier, 2013)
Morbidly obese patients have associated diseases, such as diabetes, hypertension, hyperlipidemia, and cardiovascular disease. Bariatric surgery improves these obesity-related co-morbidities, including insulin resistance. ... -
Relación de la obesidad y la diabetes tipo 2 con los niveles plasmáticos de vitamina D y con la expresión génica del receptor de vitamina D en tejido adiposo.
Muñoz-Garach, Araceli; Clemente-Postigo, María Mercedes; Garrido López, Lourdes; Bernal-López, Rosa; Moreno-Santos, Inmaculada; Castellano-Castillo, Daniel; Fernández-García, Diego; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (Elsevier, 2013-05-15)
Introducción: Se ha descrito que la deficiencia de vitamina D está asociada con la obesidad y la diabetes. Sin embargo, los re- sultados de los diferentes estudios no llegan a ser del todo conclu- yentes. Asimismo, se ha ... -
Relación de los niveles de vitamina D y la expresión de VDR en tejido adiposo con el índice de masa corporal y el perfil glucémico.
Clemente-Postigo, María Mercedes; Muñoz-Garach, Araceli; Garrido-Sánchez, Lourdes; Bernal-López, Rosa; Moreno-Santos, Inmaculada; Castellano-Castillo, Daniel; Fernández-García, Diego; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (2012)
Este estudio analizó la relación entre los niveles de vitamina D (25(OH)D3), la expresión del receptor de vitamina D (VDR) en tejido adiposo visceral, el índice de masa corporal (IMC) y el perfil glucémico en 119 sujetos ... -
Serum 25-Hydroxyvitamin D and Adipose Tissue Vitamin D Receptor Gene Expression: Relationship with Obesity and Type 2 Diabetes
Clemente-Postigo, María Mercedes; Muñoz Garach, Araceli; Serrano, Marta; Garrido-Sánchez, Lourdes; Bernal-López, María Rosa; Fernandez-García, Diego; Moreno Santos, Inmaculada; Garriga, Nuria; Castellano-Castillo, Daniel; Camargo, Antonio; Fernández Real, José M; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (Endocrine Society, 2015)
Context: The relationship between 25-hydroxyvitamin D [25(OH)D] and obesity and type 2 diabetes is not completely understood. Vitamin D receptor (VDR) expression in adipose tissue (AT) is related to obesity and might be ...